Estimating Production Data for Five Engineered Nanomaterials As a Basis for Exposure Assessment

Hendren, Christine Ogilvie; Mesnard, Xavier; Dröge, Jocelyn; Wiesner, Mark R.

doi:10.1021/es2009924

Cited by 109 publications

(146 citation statements)

References 0 publications

Supporting

Mentioning

145

Contrasting

Order By: Relevance

“…Human serum albumin (HSA, MW: 66 478) proteins were obtained from Sigma. Silver nanoparticles were selected due to their increasing mass production and domestic use, 27 while the selection of HSA was based on its high abundance among plasma proteins. The zeta-potentials of AgNPs and HSA in Milli-Q water (pH ¼ 6.5) were determined to be À31 mV and À17 mV, respectively (ZetaSizer Nano, Malvern).…”

mentioning

confidence: 99%

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

Chen

Choudhary

Schurr

et al. 2012

Applied Physics Letters

View full text Add to dashboard Cite

The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein "corona" has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology.

show abstract

mentioning

confidence: 99%

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

Chen

Choudhary

Schurr

et al. 2012

Applied Physics Letters

View full text Add to dashboard Cite

show abstract

“…6 Any suspension medium associated with the nanomaterial sample (as originally sourced) should only be described using a Material file "Material Description" column. 7 Any impurities should be described using entries in the relevant Material file "Characteristics [….]"…”

Section: Business Rule Nomentioning

confidence: 99%

“…6 The current templates are not best suited to capturing experimental data for all kinds of samples. 7…”

Section: Some Notable Limitations Of the Nanopuzzles Templates And Bumentioning

confidence: 99%

“…(It should be noted that slightly different definitions of these terms have been proposed by different organisations [1] and the European Commission has recommended a specific definition of a "nanomaterial" for legislative and policy purposes within the European Union [5].) Nanomaterials have been used and/or have been investigated for use in a diverse range of applications such as sunscreens, cosmetics, electronics and medical applications [2,4,6,7]. In addition to interest in the benefits offered by nanotechnology, concerns have also been raised about the potential risk posed by nanomaterials to human health and the environment [3,4,7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

Robinson¹,

Cronin²,

Richarz³

et al. 2016

Nano Online

View full text Add to dashboard Cite

Analysis of trends in nanotoxicology data and the development of data driven models for nanotoxicity is facilitated by the reporting of data using a standardised electronic format. ISA-TAB-Nano has been proposed as such a format. However, in order to build useful datasets according to this format, a variety of issues has to be addressed.These issues include questions regarding exactly which (meta)data to report and how to report them. The current article discusses some of the challenges associated with the use of ISA-TAB-Nano and presents a set of resources designed to facilitate the manual creation of ISA-TAB-Nano datasets from the nanotoxicology literature. These resources were developed within the context of the NanoPUZZLES EU project and include data collection templates, corresponding business rules that extend the generic ISA-TAB-Nano specification as well as Python code to facilitate parsing and integration of these datasets within other nanoinformatics resources. The use of these resources is illustrated by a "Toy Dataset" presented in the Supporting Information. The strengths and weaknesses of the resources are discussed along with possible future developments.

show abstract

“…There are little data available for the industrial production and release of NMs, and as a consequence studies modelling production levels of NMs have relied on extrapolated data. 16 Hospitals use NMs extensively for health care, for example in imaging (gold and Q-dot NMs), antimicrobial wound dressings (silver and copper NMs) and for drug delivery and gene therapy (polymer/liposome-based NMs). Modelling approaches used to assess gold NM PECs, however, indicate at current usages; even at hot spot discharges from hospitals, they are unlikely to be an environmental problem.…”

Section: Nm Sources and Entry Into Aquatic Environmentsmentioning

confidence: 99%

Ecotoxicology of Nanomaterials in Aquatic Systems

Jennings¹,

Goodhead²,

Tyler³

2015

Frontiers of Nanoscience

View full text Add to dashboard Cite

Estimating Production Data for Five Engineered Nanomaterials As a Basis for Exposure Assessment

Cited by 109 publications

References 0 publications

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

Ecotoxicology of Nanomaterials in Aquatic Systems

Contact Info

Product

Resources

About