Estimating Sickle Cell Disease Child Mortality from the 2018 Nigeria Demographic and Health Survey

Nnodu, Obiageli; Oron, Assaf P.; Sopekan, Alayo; Akaba, Godwin; Piel, Frédéric B.; Chao, Dennis L.

doi:10.2139/ssrn.3825539

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For each stratum in the DHS data, we drew clusters with replacement. Sampling by cluster instead of by individual preserved the clustering of children within households and households within villages [11,12]. We performed this procedure 1000 times to generate 1000 populations.…”

Section: Methodsmentioning

confidence: 99%

The contribution of malaria and sickle cell disease to anaemia among children aged 6 to 59 months in Nigeria: A secondary analysis using data from the 2018 Demographic and Health Survey

Chao

Oron

Chabot-Couture

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Introduction: Anaemia is a major cause of morbidity and mortality among children in sub-Saharan Africa. Anaemia has many aetiologies best addressed by different treatments, so regional studies of the aetiology of anaemia may be required. Methods: We analysed data from Nigeria's 2018 Demographic and Health Survey (DHS) to study predictors of anaemia among children ages 6-59m. We computed the fraction of anaemia at different degrees of severity attributable to malaria and sickle cell disease (SCD) using a regression model adjusting for demographic and socioeconomic risk factors. We also estimated the contribution of the risk factors to haemoglobin concentration. Results: We found that 63.7% (95% CI: 58.3-69.4) of semi-severe anaemia (<80 g/L) was attributable to malaria compared to 12.4% (95% CI: 11.1-13.7) of mild-to-severe (adjusted haemoglobin concentration <110 g/L) and 29.6% (95% CI: 29.6-31.8) of moderate-to-severe (<100 g/L) anaemia and that SCD contributed 0.6% (95%CI: 0.4-0.9), 1.3% (95% CI: 1.0-1.7), and 7.3% (95%CI: 5.3-9.4) mild-to-severe, moderate-to-severe, and semi-severe anaemia, respectively. Sickle trait was protective against anaemia and was associated with higher haemoglobin concentration compared to children with normal haemoglobin (HbAA) among malaria-positive but not malaria-negative children. Conclusion: This approach used offers a new tool to estimate the contribution of malaria to anaemia in many settings using widely available DHS data. The fraction of anaemia among young children in Nigeria attributable to malaria and SCD is higher at more severe levels of anaemia. Prevention of malaria and SCD and timely treatment of affected individuals would reduce cases of severe anaemia.

show abstract

Section: Methodsmentioning

confidence: 99%

The contribution of malaria and sickle cell disease to anaemia among children aged 6 to 59 months in Nigeria: A secondary analysis using data from the 2018 Demographic and Health Survey

Chao

Oron

Chabot-Couture

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…All the participating policymakers recognized SCD as one of the top ten noncommunicable diseases causing significant disability, morbidity and mortality and impacting negatively on the attainment of Sustainable Development Goals 1, 3, 4, and 10 in Nigeria. They also agreed that poor integration of SCD prevention and control services with other health and nonhealth services especially maternal and child health services, as well as the inability of the government to mobilize the much-needed resources for SCD interventions and uncoordinated activities of NGOs and researchers on SCD in Nigeria, were issues that needed to be dealt with for muchneeded progress to be made in improving SCD care (Nnodu Obiageli et al, 2020;Nnodu et al, 2021).…”

Section: Challenges/burden Of Scd In Nigeriamentioning

confidence: 99%

Strategies to improve healthcare services for patients with sickle cell disease in Nigeria: The perspectives of stakeholders

Isa

Okocha²,

Adegoke³

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

Background: Sickle cell disease (SCD) continues to pose physical and psychosocial burdens to patients, caregivers and health workers. Stakeholder engagement in the processes of policy making and implementation is increasingly becoming the cornerstone of best practices in healthcare.Aim and Objectives: To engage stakeholders with a view to assessing the knowledge of SCD; ascertain the challenges associated with accessibility and affordability of healthcare services; improve the quality of care, and thereby effect behavioral change through increasing attendance and follow-up of patients in the clinics.Methodology: A Stakeholders’ Engagement meeting organized by the Sickle Pan Africa Research Consortium Nigeria Network (SPARC-NEt) was attended by patients, caregivers and members of patient support groups, healthcare providers and management/policymakers. The engagement was through PowerPoint presentations, structured questionnaires and an interactive session. The structured questionnaire assessed the knowledge of stakeholders about SCD; the quality of healthcare services; challenges with access and affordability; and SCD-related government policies.Results: Three hundred and twelve stakeholders attended the engagement meeting. Of the 133 that participated in the study, medical workers were the most represented. The majority had good knowledge of what causes SCD (96.2%) and the best place to get help during SCD crisis (98.5%). However, knowledge of the specific preventive measures of SCD and its crisis was not optimal. In terms of the role of community engagement and education, only about one-quarter of the study participants, 34 (25.6%) knew about their positive role in reducing the prevalence of SCD and alleviating SCD crises. Challenges identified include inadequate healthcare personnel and facilities, delay in obtaining laboratory results, long waiting time in the clinic, poor communication, absence of holistic consultation, uncoordinated healthcare services, high cost of care, ignorance, non-prioritization of SCD by government, lack of multisectoral collaboration and partnership with NGOs and international organizations. Strategies proffered to improve healthcare services include, community/stakeholder engagement and health education, sickle cell daycare services, access to a willing and dedicated multidisciplinary workforce, collaboration with support groups and government policies and programs.Conclusion: There is need for regular stakeholder engagement to improve access to healthcare services for SCD patients in Nigeria.

show abstract

Estimating Sickle Cell Disease Child Mortality from the 2018 Nigeria Demographic and Health Survey

Cited by 2 publications

References 0 publications

The contribution of malaria and sickle cell disease to anaemia among children aged 6 to 59 months in Nigeria: A secondary analysis using data from the 2018 Demographic and Health Survey

The contribution of malaria and sickle cell disease to anaemia among children aged 6 to 59 months in Nigeria: A secondary analysis using data from the 2018 Demographic and Health Survey

Strategies to improve healthcare services for patients with sickle cell disease in Nigeria: The perspectives of stakeholders

Contact Info

Product

Resources

About