Estimating the minimum important change in the 15D scores

Alanne, Soili; Roine, Risto P.; Räsänen, Pirjo; Vainiola, Tarja; Sintonen, Harri

doi:10.1007/s11136-014-0787-4

Cited by 200 publications

(220 citation statements)

References 24 publications

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“…A higher score reflects a better HRQoL. The minimum important change for the 15D score is estimated to be ±0.015, and 0.015 can also be regarded as the minimum clinically important cross-sectional difference between groups [10]. …”

Section: Methodsmentioning

confidence: 99%

Health-Related Quality of Life in Patients with Small Intestine Neuroendocrine Tumors

et al. 2018

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Background: The prevalence of small intestine neuroendocrine tumors (SI-NETs) is increasing. Disease progression is often slow and treatment options and long-term survival rates have improved, but little is known about health-related quality of life (HRQoL) in these patients. Objective: To assess HRQoL and its predictors in SI-NET patients receiving contemporary treatments. Methods: We measured HRQoL with 15D and SF-36 questionnaires in 134 SI-NET patients and compared the 15D results to those of an age- and gender-standardized sample of the general population (n = 1,153). In the patients, we studied the impact of treatments, Ki-67, liver metastases, circulating tumor markers, comorbidities, and/or socioeconomic factors on HRQoL with linear regression analysis. Results: The mean disease duration of the patients was 81 (4–468) months, 91% had metastatic disease, and 79% received somatostatin analog treatment. Hepatic tumor load was 0% in 44.8%, < 10–25% in 44.0%, and > 25% in 11.2%, respectively. Mean fP-CgA and S-5HIAA concentrations were 15 (1.3–250) and 344 (24–7,470) nmol/L, respectively. Overall, HRQoL was significantly impaired in patients compared to controls (15D score 0.864 ± 0.105 vs. 0.905 ± 0.028, p < 0.001). SI-NET patients scored worse on 9 of 15 dimensions: sleep, excretion (i.e., bladder and bowel function), depression, distress, vitality, sexual activity (p < 0.001), breathing, usual activities, and discomfort and symptoms (p < 0.01–0.05). SF-36 scores were impaired and highly correlated with 15D scores (p < 0.001). HRQoL was impaired in patients with (n = 85) compared to patients without (n = 49) impaired excretion (0.828 vs. 0.933, p < 0.001). In the patient group, number of medications predicted impaired HRQoL. Conclusions: Despite contemporary treatments, SI-NET patients have severely impaired HRQoL, including diarrhea, sleep, depression, vitality, and sexual activity.

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Section: Methodsmentioning

confidence: 99%

Health-Related Quality of Life in Patients with Small Intestine Neuroendocrine Tumors

et al. 2018

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“…A difference !0.015 in the 15D score is estimated to be clinically important. 20 The authors hypothesized that the patients enjoy a HRQoL comparable to that of an age-standardized general population.…”

Section: Outcome Measuresmentioning

confidence: 99%

Treatment of compound tibia fracture with microvascular latissimus dorsi flap and the Ilizarov technique: A cross-sectional study of long-term outcomes

Repo

Barner-Rasmussen

Roine

et al. 2016

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Summary Background: Extensive compound tibial fractures present reconstructive challenges. The present study aimed to assess the outcomes of microvascular latissimus dorsi (LD) flap combined with the Ilizarov technique for extensive compound tibial fractures with bone loss and bone healing complications. Methods: Patient records were reviewed retrospectively. The Lower Extremity Functional Scale (LEFS), the Disabilities of the Arm, Hand and Shoulder (DASH), and the 15D healthrelated quality of life (HRQoL) instrument were applied. Results: Between 1989 and 2014, 16 patients underwent reconstruction with a microvascular LD flap and bone transport (11/16) or late bone lengthening (5/16). The mean clinical follow-up time was 6.6 (standard deviation (SD): 6.5) years. Three patients had minor complications requiring reoperation. Partial necrosis of one flap required late flap reconstruction in one case. Late bone grafting was used to enhance union in eight of 16 cases. The mean new bone gain was 3.8 cm (SD: 2.5).Overall, 11 patients completed the questionnaires in a mean of 22.3 years (SD: 2.4) after surgery. The main findings revealed a relatively good function of the reconstructed limb and good shoulder function. The mean HRQoL was comparable to that of an age-standardized sample of the general population.

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“…For the 15D, deterioration of 0.02 to 0.14 units was found in baseline values ranging from 0.79 to 0.85. One previous study has established 0.02 units as the minimum important change (MIC) for the 15D [50]. In sum, more studies to investigate either the MDC or MCID for HRQoL among PwMS are needed.…”

Section: Discussionmentioning

confidence: 99%

Ten-year follow-up of health-related quality of life among ambulatory persons with multiple sclerosis at baseline

2016

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2 ABSTRACTPurpose: The aim of this 10-year follow-up study was to determine changes in health-related quality of life (HRQoL) over time among ambulatory persons with MS (PwMS) at the baseline using generic and disease-specific instruments. Methods Conclusions:The results of this study suggest that ambulatory PwMS at baseline reported reduced HRQoL in physical functioning after a 10-year follow-up period while emotional well-being was maintained and social functioning improved. The scores in the other HRQoL dimensions and scales remained unchanged. More long-term population-based studies are needed to precisely determine the development of HRQoL among PwMS.

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Estimating the minimum important change in the 15D scores

Abstract: The generic MICs for the change of 15D scores are ±.015. Follow-up studies using the 15D should report the mean change in the 15D score, its statistical significance, relationship to the MIC, and the distribution of the changes of the 15D scores into the five categories.

Cited by 200 publications

References 24 publications

Health-Related Quality of Life in Patients with Small Intestine Neuroendocrine Tumors

Health-Related Quality of Life in Patients with Small Intestine Neuroendocrine Tumors

Treatment of compound tibia fracture with microvascular latissimus dorsi flap and the Ilizarov technique: A cross-sectional study of long-term outcomes

Ten-year follow-up of health-related quality of life among ambulatory persons with multiple sclerosis at baseline

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