Estimation and Assessment of Plasma D-Dimer Levels in HIV Patients

Himmat, Wafa Hamid Haroun; Gaufri, Nasr Eldeen Ali Mohammed

doi:10.4236/jbm.2016.410001

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…This study uncovered that DD levels are fundamentally higher in HIV patients when compared to control. These outcomes are identical to previous studies that pointed to the considerable increase in DD in HIV cases [19,20]. A high DD level suggests that the body has recently experienced clot formation and disintegration.…”

Section: Discussionsupporting

confidence: 89%

Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients

Bashir,

Mohamed,

Hussain

et al. 2023

Medicina

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Background and Objectives: HIV disease is recognized to cause inconsistencies in coagulation via various pathways during infection. Some studies have indicated that HIV-infected patients are prone to developing thrombocytopenia, thrombosis, or autoantibodies that may cause difficulties in diagnosis. This study is intended to measure the trend of coagulation parameters in Sudanese patients with HIV. Materials and Methods: A cross-sectional study was carried out in patients with HIV admitted to the Sudan National AIDS Program (SNAP) from January 2018 to December 2019. Prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), D-dimer (DD), hemoglobin (HB), total lymphocyte count (TLC), platelet count (PLT), and a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13), were evaluated among HIV Sudanese patients. Results: Out of the 44 HIV patients included, 6 (13.6%) were found to have thrombotic thrombocytopenic purpura-like events and 12 (27.2%) had antiphospholipid antibodies, of whom 8 (66.6%) showed anticardiolipin antibody (1gG (75%) and IgM (25%)) and 4 showed lupus anticoagulants. The HB, TLC, and PLT values were found to be significantly lower in HIV patients than in control (p = 0.000, 0.000, and 0.050, respectively). The PT and ADAMTS13 values showed no significant difference between HIV patients and control (p = 0.613 and 0.266, respectively). The PTT, TT, and DD values were found to be augmented in HIV patients versus the control (p = 0.000). Conclusions: Thrombotic thrombocytopenic purpura-like events among HIV Sudanese patients were explored. In addition, antiphospholipid antibodies were strikingly seen in these patients. Additional research is anticipated to confirm these diagnoses.

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Section: Discussionsupporting

confidence: 89%

Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients

Bashir,

Mohamed,

Hussain

et al. 2023

Medicina

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“…Kuller LH et al [21], investigated the relationship between inflammatory and coagulation biomarkers and morta8ity in HIV patients. They conclude that most etiological agent of fatality was intimately associated to IL-6 and D-dimer concentrations; through elevating IL-6 and D-dimer levels, and discontinuing antiretroviral therapies (ART) may raise the chances of mortality even more, in line with a study conducted in Sudan by Himmat et al in [22].…”

Section: Discussionsupporting

confidence: 61%

Measurement of Plasma Fibrinogen Levels, PT and APTT among HIV Infected Patients: A Critical Bio-Marker for Coagulation Dysfunctions

Ahmed

Gaufri

Abdelgani

et al. 2021

JPRI

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Background: The literature stated that Human immunodeficiency virus (HIV) infection led to activation of coagulation, and habitually linked with an augmented risk of venous and arterial thrombosis. So the purpose of the study was to determine the plasma fibrinogen level in Sudanese HIV-infected patients. Materials and Methods: A total of one hundred participants were recruited, and classified into two groups; the case group include (50) HIV patients, and the control group enrolled (50) healthy individuals. Three ml of blood was collected. Fresh Poor Plasma was prepared from citrated venous blood by centrifuged for 15 minutes at 3000 pm. Fibrinogen levels were measured by an automated coagulation analyzer (Thrombolyzer XRC Germany). Data were collected using a directly structured questionnaire. Data were analyzed using SPSS Version 21. Results: The present study showed that the mean of plasma fibrinogen levels was statistically significantly higher in HIV infection in comparison with those normal healthy control (470.50 ±67.75 vs 214.75±21.25 with P-value 0.00). There was a significantly decreased level of PT, and PTT among the HIV group comparing with the control (9.575±0.64, and 22.39±4.94) VS (12.483±0.72, and 30.78±3.55) consequently, (P-value ≤0.001). Fibrinogen levels were significantly increased with the progression of HIV disease (469.84 ±67.15, 472.74 ±87.75, 478.47 ±61.92) in stage I, stage II, and stage III respectively. Conclusions: An HIV-infected patient had elevated plasma fibrinogen levels, as well as other coagulation dysfunctions.

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“…However, it was lower in HAART-treated patients than treatment naïve HIV-infected patients. Several studies confirm that the level of D-dimer is higher in HIV patients than those in hiv-seronegative controls [ 19 , 41 , 68 ]. Hypercoagulable state and activated coagulation system in HIV-infected individuals have been reported in different literature [ 56 , 69 ].…”

Section: Discussionmentioning

confidence: 94%

“…A total of 7,498 participants (2,270 on HAART and 1,144 HAART-naïve HIV-infected patients and 3,584 HIV-seronegative controls) were used to analyze and compare coagulation parameters (PT, APTT, fibrinogen, D-dimer, and PLT) in those participants. A total of 18 studies were included; of them 9 studies had been conducted in Nigeria [ 30 – 38 ], 2 from India [ 39 , 40 ], and the remaining 7 were from Sudan [ 41 ], Kenya [ 42 ], Ghana [ 43 ], Iran [ 44 ], Brazil [ 45 ], Netherland [ 46 ], and Denmark [ 47 ]. The included studies had case-control, comparative cross-sectional, and prospective cohort in their study design.…”

Section: Resultsmentioning

confidence: 99%

Coagulation Parameters in Human Immunodeficiency Virus Infected Patients: A Systematic Review and Meta-Analysis

Getawa

Adane

2022

AIDS Research and Treatment

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Background. Coagulation abnormalities are common complications of human immunodeficiency virus (HIV) infection. Highly active antiretroviral treatment (HAART) decreased the mortality of HIV but increased coagulopathies. HIV-related thrombocytopenia, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), and high D-dimer level commonly manifested in patients with HIV. Thus, this study is aimed to compare coagulation parameters of HAART-treated and HAART-naïve HIV-infected patients with HIV-seronegative controls. Methods. A systematic literature search was conducted using the databases PubMed/MEDLINE, Embase, Web of Science, and Google Scholar of studies published until July 2021. The primary outcome of interest was determining the pooled mean difference of coagulation parameters between HIV-infected patients and seronegative controls. The Joana Briggs Institute (JBI) critical appraisal tool was used for quality appraisal. Statistical analyses were performed using Stata11.0 software. The statistical results were expressed as the effect measured by standardized mean difference (SMD) with their related 95% confidence interval (CI). Results. A total of 7,498 participants (1,144 HAART-naïve patients and 2,270 HAART-treated HIV-infected patients and 3,584 HIV-seronegative controls) from 18 studies were included. HIV-infected patients (both on HAART and HAART-naive) exhibited significantly higher levels of PT than HIV-seronegative controls (SMD = 0.66; 95% CI: 0.53–0.80 and SMD = 1.13; 95% CI: 0.60–2.0, respectively). The value of APTT was significantly higher in patients with HIV on HAART than in seronegative controls. However, the values of PLT count, APTT, and fibrinogen level were significantly higher in seronegative controls. Besides, the level of fibrinogen was significantly higher in HAART-treated than treatment-naïve patients (SMD = 0.32; 95%CI: 0.08, 0.57). Moreover, the level of APTT and PT had no statistical difference between HAART and HAART-naïve HIV-infected patients. Conclusions. This study identified that HIV-infected patients are more likely to develop coagulation abnormalities than HIV-seronegative controls. Therefore, coagulation parameters should be assessed regularly to prevent and monitor coagulation disorders in HIV-infected patients.

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Estimation and Assessment of Plasma D-Dimer Levels in HIV Patients

Cited by 4 publications

References 28 publications

Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients

Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients

Measurement of Plasma Fibrinogen Levels, PT and APTT among HIV Infected Patients: A Critical Bio-Marker for Coagulation Dysfunctions

Coagulation Parameters in Human Immunodeficiency Virus Infected Patients: A Systematic Review and Meta-Analysis

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