Estimation and comparison of salivary secretory leukocyte protease inhibitor in human immunodeficiency virus patients and healthy individuals

Pushpanshu, Kumar; Sathawane, Ramhari; Kaushik, Rachna

doi:10.4103/0973-1075.125551

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…29-33 However, other studies have indicated that HIV-1 infection may increase salivary SLPI. 40,41 For these reasons, in the current study we chose to investigate SLPI levels in an HIV + cohort to reduce potential confounding. Moreover, this cohort is far more afflicted by precancerous anal lesions and anal cancer, which was the focus of this study.…”

Section: Discussionmentioning

confidence: 99%

Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients

Nicol

Brunette

Nuovo

et al. 2016

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Objective The aim of the current study was to evaluate secretory leukocyte protease inhibitor (SLPI) expression in anal biopsies from HIV-positive (HIV+) individuals, and compare that to anal intraepithelial neoplasia (AIN) diagnoses and human papillomavirus (HPV) status. Design This is a cross-sectional study of a cohort of 54 HIV+ (31 males and 23 females) from an AIDS clinic in Rio de Janeiro, Brazil. Methods The study material consisted of anorectal tissue biopsies obtained from HIV+ subjects, which were used to construct tissue microarray paraffin blocks for immunohistochemical analysis of SLPI expression. Biopsies were evaluated by an expert pathologist and classified as low-grade anal intraepithelial neoplasia (AIN1), high-grade anal intraepithelial neoplasia (AIN2/3), or normal squamous epithelium. Additionally, DNA from the biopsies was extracted and analyzed for the presence of low- or high-risk HPV DNA. Results Histologically normal squamous epithelium from the anorectal region showed strong positive SLPI staining in 17/20 (85%) samples. In comparison, 9/17 (53%) dysplastic squamous epithelial samples from AIN1 patients showed strong SLPI staining, and only 5/17 (29%) samples from AIN2-3 patients exhibited strong SPLI staining, which both were significantly fewer than those from normal tissue (p=0.005). Furthermore, there was a significantly higher proportion of samples in which oncogenic high-risk HPV genotypes were detected in low SLPI expressing tissues than that in tissues with high SLPI expression (p=0.040). Conclusion Taken together these results suggest that low SLPI expression is associated with high-risk HPV infections in the development of AIN.

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Section: Discussionmentioning

confidence: 99%

Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients

Nicol

Brunette

Nuovo

et al. 2016

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Дані щодо рівня SLPI при різних захворюваннях за наявності вірусної інфекції є суперечнимипосилення його рівня в слині спостерігалось у хворих з ВІЛ-інфекцією [19] і зниження експресії SLPI в Епштейна-Барр-позитивних клітинах тканин у онкологічних пацієнтів [25]. Отже, значимість інгібіторів у регуляції внутрішньоклітинного протеолізу при розвитку патологічних процесів, в тому числі в нирці, залишається до кінця не розкритою.…”

Section: вступunclassified

Non-Specific Protection Factors and Inflammatory Mediators in Urine of Children With Glomerulonephritis in the Presence of Herpesviral Infection Notice 2. Determination of the Level of Il-8 and Slpi

Багдасарова

Kruglikova

Корнилина

et al. 2016

Ukr. Journ. Nephrol. and Dial.

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The aim of this work was the study of indicators characterizing the local immunity in patients with various forms of glomerulonephritis by presence of herpesviral infection. Materials and methods. A quantitative estimation of the content of IL-8 and SLPI in urine of 47 patients with glomerulonephritis and 10 apparently healthy individuals was conducted. Results. A insignificant increase of IL-8 level in urine was showed in patients with glomerulonephritis. The level of urinary SLPI was reliably higher than the control value, at the same time the majority ofpatients (74,0 %) did not exceed the upper limit of the physiological norm. The essential increase ofIL-8 level in urine was observed in 13 sick children, and of SLPI – in 12 patients. The increase of IL-8 and SLPI levels was observed more frequently in patients with hematuric form of glomerulonephritis, with nephrotic steroidoresistant variant of nephrotic form, in the absence of remission, and in the case of IL-8 - with severe course of the disease. More such changes were found in children with active (reactivated) herpesviral infections. Conclusion. There has been confirmed the importance of the study of immunologic parameters in the urine of patients with glomerulonephritis to characterize immunopathological process in the kidney and prognosis of the disease.

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“…[3] Initially studied for its role in the prevention of HIV transmission in saliva, SLPI has recently been recognized as a potential diagnostic and prognostic marker in the head-and-neck cancer. [4] It is found in most secretions of the body and mainly in saliva. [5] Previous research on SLPI has used brush biopsy specimens in OPMD and OSCC.…”

Section: Introductionmentioning

confidence: 99%

Secretory Leukocyte Protease Inhibitor in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Ajila

Babu

Shetty

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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Objectives: Secretory leukocyte protease inhibitor (SLPI) is a protein found in body fluids and implicated as a prognostic factor in many cancers. There is limited research regarding serum and salivary SLPI in oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC). Materials and Methods: A total of 90 participants were included in the study; of which 30 formed the control group, 30 included participants with OPMD, and 30 included participants with OSCC. Serum and salivary levels of SLPI were estimated using enzyme-linked immunosorbent assay. Results: Serum levels of SLPI showed progressive increase in potentially malignant disorders and SCC patients when compared with controls, while salivary levels were increased in both OPMD and OSCC groups as compared to controls. However, the difference between groups was not statistically significant ( P < 0.05). Conclusion: The above results suggest that increase in SLPI levels in the serum may have a role in indicating progression of OPMD to OSCC.

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Estimation and comparison of salivary secretory leukocyte protease inhibitor in human immunodeficiency virus patients and healthy individuals

Cited by 4 publications

References 17 publications

Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients

Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients

Non-Specific Protection Factors and Inflammatory Mediators in Urine of Children With Glomerulonephritis in the Presence of Herpesviral Infection Notice 2. Determination of the Level of Il-8 and Slpi

Secretory Leukocyte Protease Inhibitor in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

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