2007
DOI: 10.1111/j.1365-2885.2007.00878.x
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Estimation of absolute oral bioavailability of moxidectin in dogs using a semi‐simultaneous method: influence of lipid co‐administration

Abstract: Moxidectin is a long-acting anthelmintic drug for which little is known about its kinetic behaviour in dogs and its oral absolute bioavailability has never been reported. We studied the pharmacokinetics of moxidectin in dogs, with a special emphasis on oral bioavailability and the influence of lipid co-administration, by using a semi-simultaneous method of administration. Ten Beagle dogs were dosed orally and then intravenously (i.v.) with 0.2 mg/kg moxidectin. The oral application was conducted with or withou… Show more

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Cited by 21 publications
(18 citation statements)
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“…44,46 Moxidectin is highly bioavailable after oral dosing: about 90% of the drug is absorbed in dogs. 47 Reported elimination half-lives in dogs vary from 13.9 to 25.9 days. 44,46,47 This variability is associated with body condition.…”
Section: Toxicokinetics Of Macrocyclic Lactones and The Role Of P-glymentioning
confidence: 99%
See 2 more Smart Citations
“…44,46 Moxidectin is highly bioavailable after oral dosing: about 90% of the drug is absorbed in dogs. 47 Reported elimination half-lives in dogs vary from 13.9 to 25.9 days. 44,46,47 This variability is associated with body condition.…”
Section: Toxicokinetics Of Macrocyclic Lactones and The Role Of P-glymentioning
confidence: 99%
“…47 Reported elimination half-lives in dogs vary from 13.9 to 25.9 days. 44,46,47 This variability is associated with body condition. More obese dogs had a higher volume of distribution, 46,47 resulting in indirectly prolonged elimination due to distribution of the lipophilic drug into their relatively larger fat compartment.…”
Section: Toxicokinetics Of Macrocyclic Lactones and The Role Of P-glymentioning
confidence: 99%
See 1 more Smart Citation
“…Preclinical studies have shown that the absolute bioavailability of moxidectin is variable, ranging from 19% in rats to 90% in dogs (9). After oral administration, moxidectin is quickly absorbed, with the time to peak plasma concentration (t max ) being 3.7 Ϯ 1.5 h in 27 fasting healthy volunteers receiving an 8-mg dose.…”
mentioning
confidence: 99%
“…In the case of oral administration, the digestive physiology of the host is a determining factor for drug availability. In the dog with a monogastric physiology, the oral bioavailability of moxidectin was 70 to 90 % [19,20] while it is much lower in cattle [15]. However, the polygastric physiology of ruminants presents complex digestive steps including the crossing of the rumen, that slow down the absorption process and lower the availability [13].…”
Section: Pharmacokineticsmentioning
confidence: 97%