Effective identification of pollution sources is particularly important for indoor air quality. Accurate estimation of source strength is the basis for source effective identification. This paper proposes an optimization method for the deconvolution process in the source strength inverse calculation. In the scheme, the concept of time resolution was defined, and combined with different filtering positions and filtering algorithms. The measures to reduce effects of measurement noise were quantitatively analyzed. Additionally, the performances of nine deconvolution inverse algorithms under experimental and simulated conditions were evaluated and scored. The hybrid algorithms were proposed and compared with single algorithms including Tikhonov regularization and iterative methods. Results showed that for the filtering position and algorithm, Butterworth filtering performed better, and different filtering positions had little effect on the inverse calculation. For the calculation time step, the optimal
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(time resolution) was 0.667% and 1.33% in the simulation and experiment, respectively. The hybrid algorithms were found to not perform better than the single algorithms, and the SART (simultaneous algebraic reconstruction technique) algorithm from CAT (computer assisted tomography) yielded better performances in the accuracy and stability of source strength identification. The relative errors of the inverse calculation for source strength were typically below 25% using the optimization scheme.