Estimation of COVID-19–induced depletion of hospital resources in Ontario, Canada

Barrett, Kali; Khan, Yasín A.; Mac, Stephen; Ximenes, Raphael; Naimark, David; Sander, Beate

doi:10.1503/cmaj.200715

Cited by 97 publications

(95 citation statements)

References 7 publications

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“…Multiple emerging studies suggest that biomarkers may be no different in subjects with COVID-19-induced lung injury versus those due to other etiologies (Sinha et al, 2020b). However, the strength of our study lies in an assay that can potentially identify subjects presenting with COVID-19 who are likely to develop adverse outcomes during the course of their hospitalization, which becomes increasingly important when resources are constrained as has been unfortunately common during this pandemic (Barrett et al, 2020;Litton et al, 2020;Moghadas et al, 2020). Second, this study does not assess how MT-DNA correlates with viral load in COVID-19, which is especially important in the context of deciding when to intervene with targeted therapeutics (Catanzaro et al, 2020;Du and Yuan, 2020;Maggi et al, 2020).…”

Section: Discussionmentioning

confidence: 96%

Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

Scozzi

Cano

et al. 2020

Preprint

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SUMMARYMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether the appearance of cell-free MT-DNA is linked to poor COVID-19 outcomes remains undetermined. Here, we quantified circulating MT-DNA in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at the time of hospital presentation. Circulating MT-DNA were sharply elevated in patients who eventually died, required ICU admission or intubation. Multivariate regression analysis revealed that high circulating MT-DNA levels is an independent risk factor for all of these outcomes after adjusting for age, sex and comorbidities. Additionally, we found that circulating MT-DNA has a similar or superior area-under-the curve when compared to clinically established measures of systemic inflammation, as well as emerging markers currently of interest as investigational targets for COVID-19 therapy. These results show that high circulating MT-DNA levels is a potential indicator for poor COVID-19 outcomes.

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Section: Discussionmentioning

confidence: 96%

Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

Scozzi

Cano

et al. 2020

Preprint

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“…For predictions of occupancy of ICU Beds in Ontario according to low, medium and high risk scenarios, we used an individual-level simulation to model the flow of patients with COVID-19 through the hospital system in Ontario as previously described. 12 In the low risk scenario, new SARS-CoV-2 infections were assumed to…”

Section: Methods Used For This Science Briefmentioning

confidence: 99%

Evidence to Support Further Public Health Measures in High Transmission Areas in Ontario

Jüni¹,

Sander²,

Tuite³

et al. 2020

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Brown on behalf of the Ontario COVID-19 Science Advisory Table and Modelling Consensus Table. *PJ and BS contributed equally to this Science Brief Key Message The number of SARS-CoV-2 infections in Ontario has progressively increased in September and October 2020. There is new evidence that suggests that indoor spaces where masks cannot be worn at all times and/or where it is difficult to maintain physical distancing are important risk factors for the transmission of SARS-CoV-2. Targeted public health measures in regions with high transmission are needed to avoid further increases in COVID-19 cases and to avoid more stringent public health prevention measures in the future.

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“…Prone positioning of patients with COVID-19 on medical wards may become a more common practice in an effort to prevent mechanical ventilation if critical care resources become overwhelmed. As modelling studies have indicated this may be a risk for Canadian hospitals if public interventions are not followed, 35,36 hospitals should therefore develop or adopt guidance on prone positioning and support rapid knowledge translation and training of clinical staff. As an example, Doussot and colleagues described the creation of a dedicated prone-positioning team at a regional hospital in France.…”

Section: What Are the Logistical Considerations For Using Prone Positmentioning

confidence: 99%

Prone positioning for patients with hypoxic respiratory failure related to COVID-19

Venus

Munshi

Fralick

2020

CMAJ

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Estimation of COVID-19–induced depletion of hospital resources in Ontario, Canada

Cited by 97 publications

References 7 publications

Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

Evidence to Support Further Public Health Measures in High Transmission Areas in Ontario

Prone positioning for patients with hypoxic respiratory failure related to COVID-19

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