Molding compounds (MCs) have been used extensively as an encapsulation material for integrated circuits, however, MCs are susceptible to moisture and charge spreading over time.The increase in dissipation factor due to increase of parasitic electrical conductivity ( ) and the decrease in dielectric strength restrict their applications. Thus, a fundamental understanding of moisture transport will suggest strategies to suppress moisture diffusion and broaden their applications. In this paper, we 1) propose a generalized effective medium and solubility (GEMS) Langmuir model to quantify water uptake as a function of filler configuration and relative humidity; 2) investigate dominant impact of reacted-water on through numerical simulations, mass-uptake, and DC conductivity measurements; 3) investigate electric field distribution to explain how moisture ingress reduces ; and finally 4) optimize the filler configuration to lower the dissipation factor, and enhance .The GEMS-Langmuir model can be used for any application (e.g., photovoltaics, biosensors)where moisture diffusion leads to reliability challenges.