Estimation of Efficiency of Various Schemes of Therapy of Patients With Infectious Mononucleosis Caused by Epstein – Barr

Abstract

Background: Actuality of study of infectious mononucleosis (ІМ) is conditioned by high infected of population by the Epstein – Barr virus (EBV), specific virus affinity to the immunocompetent cells, lifelong virus persistence in an organism and often latent process. Methods: Research on the work topic was conducted at the Department of Infectious Diseases of Kharkiv National Medical University. A total of 45 patients with IM (26 men and 19 women) who were hospitalized at the Regional Clinical Hospital in 2018–2019 years were surveyed. The vast majority of patients with IM were young people aged from 18 to 25, of whom 597 % were students. Results: The clinical picture of infectious mononucleosis caused by the Epstein–Barr virus, mainly characterized by manifestations of hepatomegaly, lymphadenopathy, intoxication syndrome and nasopharyngeal tonsillitis. The efficacy of combined use of Valacyclovir and Nuclex in complex therapy of patients with infectious mononucleosis caused by Epstein – Barr virus (EBV) was studied. The use of such therapy was found to promotes regression of clinical symptoms, contribute to normalization of indices of clinical blood tests and lead to a decrease of the number of EVB's DNA copies in the blood serum or complete elimination of virus. Conclusions: Thus, evaluation of the effectiveness of the use of valacyclovir and nuclex in the complex therapy of patients with infectious mononucleosis caused by Epstein–Barr virus, indicates a more significant regression of clinical symptoms, significantly more pronounced positive impact on the indicators of clinical blood analysis and the number of copies of EBV DNA in blood serum than in the comparison group. Obtained results allowed to substantiate the use of complex therapy of valacyclovir and nuclex in patients with IM caused by EBV.

Laboratory and clinical peculiarities of the measles course in adult patients against the background of the use of a ribonucleic acid medicine in a comprehensive approach to treatment during the 2017-2019 outbreak period

“…The nuclear index (NI) has increased 11.7±0.84-fold indicating a severe inflammatory reaction, and it also reflects changes in white blood cells on antigenic and cytokine stimulation. An increase in NI indicates the presence of intoxication and a violation of the ability of neutrophils to eliminate antigen due to an increase in the number of young forms (rod-nuclear neutrophils) [10] . The presence of an acute inflammatory process reflects the intoxication index (II), which significantly increased 24.7±0.63-fold (p<0.05).…”

“…As a result of the integrated action of the virus in the cell, metabolic processes are disrupted, toxins of endogenous and exogenous origin, pyogenes, products of distorted metabolism and inflammatory mediators in nonphysiological concentrations accumulate in various biological environments, which causes the clinical-laboratory changes that characterize ESI [8,17] . According to the authors, the use of ribonucleic acid in the complex treatment of viral infections has a positive effect on the rate of recovery, as it suppresses the interaction of the virus with cell receptors due to conformational changes of the corresponding surface antigens [9,10] , has a membrane-stabilizing effect and inhibits oxidative processes. Therefore, when performing this work, we've set ourselves several tasks: to analyze the clinicallaboratory peculiarities of the course of measles in adult patients according to the data of the CNPE "Ivano-Frankovsk Regional Clinical Infectious Disease Hospital of the Ivano-Frankovsk Regional Council" (CNPE IF RCIDH IFRC), Ivano-Frankovsk, Ukraine, to determine the degree of endogenous intoxication and to find its connection with the severity of the course of the main disease, to study the effect of the ribonucleic acid medicine on the effectiveness of treatment.…”