Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement

Ishikawa, Kunio; Asaoka, Kenzo

doi:10.1002/jbm.820291210

Cited by 177 publications

(140 citation statements)

References 17 publications

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“…In this experiment, α-TCP was dissolved in the binding solution during the fabrication process of the implants. α-TCP may release Ca 2+ and PO 4 3-ions into the binding solution, and then, the solution may become supersaturated with apatite, thereby leading to the formation of spindle-shaped crystals of hydroxyapatite [11,12,23]. This phenomenon may explain the significant presence of hydroxyapatite peaks in the XRD patterns.…”

Section: Discussionmentioning

confidence: 99%

Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants

Choi

Lee

Igawa

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Artificial bone implants are often incorporated with osteoinductive factors to facilitate early bone regeneration. Calcium phosphate, the main component in artificial bone implants, strongly binds these factors, and in a few cases, the incorporated proteins are not released from the implant under conditions of physiological pH, thereby leading to reduction in their osteoinductivity. In this study, we coated tailor-made bone implants with trehalose to facilitate the release of basic fibroblast growth factor (bFGF). In an in vitro study, mouse osteoblastic cells were separately cultured for 48 hr in a medium with a untreated implant (T-), trehalose-coated implant (T+), bFGF-incorporated implant (FT-), and bFGF-incorporated implant with trehalose coating (FT+). In the FT+ group, cell viability was significantly higher than that in the other groups (P<0.05). Scanning electron microscopy (SEM) and X-ray diffraction (XRD) revealed that trehalose effectively covered the surface of the artificial bone implant without affecting the crystallinity or the mechanical strength of the artificial bone implant. These results suggest that coating artificial bone implants with trehalose could limit the binding of bFGF to calcium phosphate.KEY WORDS: artificial bone implant, bFGF, in vitro, trehalose.

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Section: Discussionmentioning

confidence: 99%

Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants

Choi

Lee

Igawa

et al. 2011

The Journal of Veterinary Medical Science

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“…(2). These apatite crystals interlock with each other to form a set mass, a phenomenon similar to the setting reaction of gypsum [12][13][14] .…”

Section: Introductionmentioning

confidence: 95%

Effects of liquid phase on basic properties of .ALPHA.-tricalcium phosphate-based apatite cement

et al. 2008

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Effects of liquid phase on the basic properties of α-tricalcuim phosphate (α-TCP)-based cement, BIOPEX ® , were investigated by employing three liquid phases: distilled water, neutral sodium hydrogen phosphate solution, and succinic acid disodium salt solution containing sodium salt of chondroitin sulfate. When mixed with neutral sodium hydrogen phosphate or succinic acid disodium salt solution, the initial setting times of the cement were 19.4±0.55 and 11.8±0.45 minutes respectively. These setting times were much shorter than that of distilled water, 88.4±0.55 minutes. Formation of needle-like crystals typical of apatite was much faster when neutral sodium hydrogen phosphate solution was used, as compared to distilled water or succinic acid disodium salt solution. Moreover, at 24 hours after mixing, the largest amount of apatite was formed when neutral sodium hydrogen phosphate solution was used, whereas use of succinic acid resulted in the least. On the final mechanical strength of the cement, that yielded with neutral sodium hydrogen phosphate solution was the highest. In contrast, lower mechanical strength was observed -especially at the initial stage -when succinic acid sodium salt was used. It was thus concluded thatα-TCP-based cement allowed accelerated transformation to apatite, and that higher mechanical strength since the initial stage was achieved when neutral sodium hydrogen phosphate solution was used as the liquid phase.

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“…On this note, apatite cement is superior over bone substitute granules or blocks in that can fill bone defects without leaving any gaps due to its self-setting ability. As for the set apatite cement, it is also a microporous material with approximately 30% porosity [15][16][17] . However, apatite cement produced at the usual mixing condition gives rise to microporosity only, which means that this conventional technique does not produce macroporosity.…”

Section: Introductionmentioning

confidence: 99%

Effects of added mannitol on the setting reaction and mechanical strength of apatite cement

Shimogoryo

Eguro²,

Kimura³

et al. 2009

Dental Materials Journal

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Apatite cement containing porogen can be a useful material for the fabrication of biporous (macro-and microporous) apatite, which has gained much attention as a bone substitute material because of its large surface area and that it improves cell penetration. In the present study, the effects of added mannitol on the setting reaction and mechanical strength of apatite cement were evaluated. Apatite cements containing 0-40 wt% of mannitol were prepared and allowed to set in 0.9% saline kept at 37°C for 1-7 days. Although the diametral tensile strength (DTS) value increased with time, it decreased with the amount of added mannitol. SEM observation and XRD analysis revealed that mannitol had no inhibitory effect on the transformation reaction of apatite cement to apatite. It was thus concluded that mannitol was a good candidate for the fabrication of biporous apatite because it is biocompatible, exhibits satisfactory dissolution behavior, and that it caused no inhibitory effects on the compositional transformation to apatitic material.

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Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement

Cited by 177 publications

References 17 publications

Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants

Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants

Effects of liquid phase on basic properties of .ALPHA.-tricalcium phosphate-based apatite cement

Effects of added mannitol on the setting reaction and mechanical strength of apatite cement

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