Estimation of influenza‐ and respiratory syncytial virus‐attributable medically attended acute respiratory infections in Germany, 2010/11‐2017/18

Heiden, Matthias an der; Buchholz, Udo; Buda, Silke

doi:10.1111/irv.12666

Influenza Resp Viruses

2019

DOI: 10.1111/irv.12666

|View full text |Cite

Estimation of influenza‐ and respiratory syncytial virus‐attributable medically attended acute respiratory infections in Germany, 2010/11‐2017/18

Matthias an der Heiden

Udo Buchholz

Silke Buda

Abstract: Background The burden of influenza in primary care is difficult to assess, since most patients with symptoms of a respiratory infection are not tested. The case definition of “medically attended acute respiratory infection” (MAARI) in the German physician sentinel is sensitive; however, it requires modelling techniques to derive estimates of disease attributable to influenza and respiratory syncytial virus (RSV). Objectives The objective of this paper was to review and … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RSV is the most common cause of respiratory-related hospitalizations in children aged <5 years worldwide. A recently published modeling study estimated that 575 000 medically attended acute respiratory infections were attributable to RSV in Germany in 2017–2018 [ 3 ]. In 2015 and 2016, an estimated 33.1–68.0 million episodes of RSV-associated lower respiratory tract infections resulted in approximately 3.2–5.1 million hospital admissions and 59 600 in-hospital deaths [ 4 , 5 ].…”

mentioning

confidence: 99%

Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study)

Hartmann

Liese

Kemmling

et al. 2022

The Journal of Infectious Diseases

View full text Add to dashboard Cite

Background Respiratory syncytial virus (RSV) is a leading cause of hospitalizations in children (≤5 years); limited data compare burden by age. Methods This single-center retrospective study included children (≤5 years) hospitalized for >24 hours with RT-PCR-confirmed RSV infection (2015–2018). Hospital length of stay (LoS), intensive care unit (ICU) admissions, ICU-LoS, supplemental oxygen and medication use were assessed. Multivariate logistic regression analyses identified predictors of hospital LoS >5 days. Results 312 patients had RSV infection (0–<6 months [35%]; 6–<12 months [15%]; 1–<2 years [25%]; 2–≤5 years [25%]); 16.3% had predefined comorbidities (excludes preterm infants). Median hospital LoS was 5.0 days and similar across age; 5.1% (16/312) were admitted to ICU (ICU-LoS 5.0 days), with those aged 0–<6 months admitted most frequently (10/108; 9.3%). Supplemental oxygen was administered in 57.7% of patients, with similar need across ages. Antibiotics were administered frequently during hospitalization (43.6%). Predictors of prolonged LoS included pneumonia (odds ratio [OR] = 2.33), supplemental oxygen need (OR = 5.09), and preterm births (OR = 3.37). High viral load (RT-PCR RSV cycle threshold value <25) was associated with greater need for supplemental oxygen. Conclusions RSV causes substantial burden in hospitalized children (≤5 years), particularly preterm infants and those aged <6 months.

show abstract

mentioning

confidence: 99%

Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study)

Hartmann

Liese

Kemmling

et al. 2022

The Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Polkowska-Kramek,

Begier,

Bruyndonckx

et al. 2024

Infect Dis Ther

View full text Add to dashboard Cite

Introduction Respiratory syncytial virus (RSV) burden in adults is underestimated mainly due to unspecific symptoms and limited standard-of-care testing. We estimated the population-based incidence of hospitalization and mortality attributable to RSV among adults with and without risk factors in Germany. Methods Weekly counts of hospitalizations and deaths for respiratory, cardiovascular, and cardiorespiratory diseases were obtained (Statutory Health Insurance database, 2015–2019). A quasi-Poisson regression model was fitted to estimate the number of hospitalizations and deaths attributable to RSV as a function of periodic and aperiodic time trends, and viral activity while allowing for potential overdispersion. Weekly counts of RSV and influenza hospitalizations in children < 2 years and adults ≥ 60 years, respectively, were used as viral activity indicators. Models were stratified by age group and risk status (defined as presence of selected comorbidities). Results Population-based RSV-attributable hospitalization incidence rates were high among adults ≥ 60 years: respiratory hospitalizations (236–363 per 100,000 person-years) and cardiorespiratory hospitalizations (584–912 per 100,000 person-years). RSV accounted for 2–3% of all cardiorespiratory hospitalizations in this age group. The increase in cardiorespiratory hospitalization risk associated with underlying risk factors was greater in 18–44 year old persons (five to sixfold higher) than in ≥ 75 year old persons (two to threefold higher). Conclusions This is a first model-based study to comprehensively assess adult RSV burden in Germany. Estimated cardiorespiratory RSV hospitalization rates increased with age and were substantially higher in people with risk factors compared to those without risk factors. Our study indicates that RSV, like other respiratory viruses, contributes to both respiratory and cardiovascular hospitalizations. Effective prevention strategies are needed, especially among older adults ≥ 60 years and among adults with underlying risk factors. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-024-00951-0.

show abstract

Influenza-Associated Excess Mortality and Hospitalization in Germany from 1996 to 2018

Schindler,

Wittenberg,

Damm

et al. 2024

Infect Dis Ther

View full text Add to dashboard Cite

Introduction Influenza-associated excess mortality and morbidity is commonly estimated using statistical methods. In Germany, the Robert Koch Institute (RKI) uses the relative mortality distribution method (RMDM) to estimate influenza-associated excess mortality without reporting age-specific values. In order to better differentiate the distribution of the disease burden, a distinction by age is of high relevance. Therefore, we aimed to revise the existing excess mortality model and provide age-specific excess mortality estimates over multiple seasons. We also used the model to determine influenza-associated excess hospitalizations, since the RKI excess hospitalization model is currently based on another approach (i.e., combination of excess physician visits and hospitalized proportion). Methods This study was a retrospective data analysis based on secondary data of the German population from 1996–2018. We adapted the RKI’s method of estimating influenza-associated excess mortality with the RMDM and also applied this approach to excess hospitalizations. We calculated the number of excess deaths/hospitalizations using weekly and age-specific data. Results Data available in Germany are suitable for addressing the restrictions of the RKI’s mortality model. In total, we estimated 175,858 (176,482 with age stratification) influenza-associated excess all cause deaths between 1995–1996 and 2017–2018 ranging from 0 (17 with age stratification) in 2005–2006 to 25,599 (25,527 with age stratification) in 2017–2018. Total influenza-associated excess deaths were comparable to RKI’s estimates in most seasons. Most excess deaths/hospitalizations occurred in patients aged ≥ 60 years (95.42%/57.49%) followed by those aged 35–59 years (3,80%/24,98%). Compared with our model, the RKI hospitalization model implies a substantial underestimation of excess hospitalizations (828,090 vs. 374,200 over all seasons). Conclusion This is the first study that provides age-specific estimates of influenza-associated excess mortality in Germany. The results clearly show that the main burden of influenza is in the elderly, for whom prevention and control measures should be prioritized. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-024-01043-9.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Estimation of influenza‐ and respiratory syncytial virus‐attributable medically attended acute respiratory infections in Germany, 2010/11‐2017/18

Cited by 4 publications

References 13 publications

Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study)

Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study)

Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Influenza-Associated Excess Mortality and Hospitalization in Germany from 1996 to 2018

Contact Info

Product

Resources

About