Estimation of normal chromium-51 ethylene diamine tetra-acetic acid clearance in children

Abstract

In order to estimate the normal range of chromium-51 ethylene diamine tetra-acetic acid (EDTA) clearance in children, we selected a series of 256 patients with past or present urinary tract infection who showed, at the time of the clearance determination, normal technetium-99m dimercaptosuccinic acid (DMSA) scintigraphy and normal left to right DMSA relative uptake. The clearance was calculated by means of either the simplified second exponential method or the 120-min single blood sample; Chantler's correction was used in order to correct for having neglected the first exponential. There was a progressive increase in clearance from the first weeks of life (mean value around 1 month: 55 ml/min/1.73 m2), with a plateau at around 18 months. Between 2 and 17 years of age, the clearance values remained constant, with a mean value of 114 ml/min/1.73 m2 (SD: 24 ml/min); this is similar to the level described for inulin clearance. No significant differences were observed between boys and girls, or between clearance values calculated with one or with two blood samples. Taking into account the hour of intravenous injection of the tracer, we did not observe any influence of the lunchtime meal on the distribution of the 51Cr-EDTA clearance values.

Correct evaluation of renal glomerular filtration rate requires clearance assays

“…It requires infusion of inulin and timed collection of urine and blood samples over 3 hours, necessitating the constant presence of staff. Good alternatives requiring fewer staff resources, such as iohexol [3,4,5] and 51 chromium-labeled ethylenediaminetetra-acetic acid ( 51 Cr-EDTA) clearance [6,7,8], have been developed. These assays are, however, also time consuming, and can take 24 h or more depending on the estimated renal function.…”

Renal Imaging

“…For example, Ham and Piepsz (1991) using a single sample at 120 min, and applying a method based on the distribution volume were able to derive a formula to calculate 51 Cr-EDTA clearance in children regardless of age and to determine reference values (Piepsz et al 1994). A multitude of other methods for calculating the 99m Tc-DTPA clearance were introduced over the last two decades.…”

Urinary endothelin-1-like immunoreactivity excretion in Wilms’ tumor survivors

“…Considering a patient population median age of 20 years, GFR and ERPF age-related reference values were equal to 114±24 ml/min/1.73 m 2 BSA [15] and 618±34 ml/min/1.73 m 2 BSA [14], respectively.…”