Estimation of salivary immunoglobulin A levels in gingivitis and chronic periodontitis patients before and after phase I periodontal therapy

Kalakonda, Butchibabu; Swaminathan, Mythili; Kumar, Sandeep; Koppolu, Pradeep; Kiran, Kotha; Muralikrishna, Tupili

doi:10.4103/2277-8632.128486

Cited by 2 publications

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“…In a similar study by Butchibabu et al, where salivary IgA was evaluated, it was reported that salivary IgA levels were increased with the periodontitis patients than healthy controls. 19 Levels of crevicular IgA in the present study were seen to be higher in type II diabetics than nondiabetics as diabetics with periodontitis are shown to have depressed chemotaxis of peripheral blood leukocytes and defect in phagocytosis. There was a correlation between crevicular IgA and HbA1c levels in both groups at baseline.…”

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confidence: 42%

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IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

et al. 2022

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Objectives To estimate gingival crevicular immunoglobulin A(IgA) using enzyme-linked immunosorbent assay (ELISA) among type II diabetic patients with periodontitis. Materials and Methods A non-randomized study was done of 40 periodontitis subjects with a mean age of 50 years and were recruited into two groups, Group A (Type II controlled diabetics with HbA1c < 7%) and Group B (non-diabetics with HbA1c between 4 and 6%). Both the groups underwent nonsurgical periodontal therapy (NSPT). The clinical parameters were recorded at baseline, 1, and 3 months. GCF sample was collected for the estimation of crevicular IgA at baseline and at 3 months. Statistical Analysis Results were analyzed using parametric tests paired t-test and Student's t-test for every assessment point. The level of significance was set at p < 0.05. Results Difference in IgA levels and clinical parameters was seen between diabetic and non-diabetic groups, which was statistically significant. Conclusion Changes in crevicular IgA levels in patients with diabetic periodontitis can be used as a novel biomarker in assessing the inflammatory status.

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Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 99%

IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

et al. 2022

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Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index

Rodrigues

Espanca²,

Costa

et al. 2018

Int J Obes

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Background/objectives Oral sensorial perception is a key aspect in food choices and knowing the mechanisms modulating such perception is of major importance in the context of child obesity, which is reaching high rates in Mediterranean countries. Salivary proteome has been linked to taste sensitivity in adults. The aim of this Search E-alert Submit Login nature international journal of obesity articles article study was to search for differences in salivary proteomes of children with different bitter or sweet taste sensitivities and to assess if these potential differences are associated with their body mass index percentile (BMI percentile). Subjects/methods 387 children aged 8-9 years old were assessed for BMI percentile and classified according to their sensitivity to bitter and sweet tastes, according to their caffeine and sucrose detection thresholds, respectively. Saliva protein composition was compared among taste sensitivity groups, taking into account BMI percentile and gender, using gel-based proteomics approaches, coupled to mass spectrometry for protein identification. Results Among the salivary proteins related to bitter taste sensitivity, higher levels of cystatins were observed in bitter-sensitive children, in the case of those of normal weight, and in bitter low-sensitive, in the case of overweight children. For sweetness, the relationship between saliva and taste perception was also dependent on BMI percentile, with several proteins (including salivary cystatins) differing between taste sensitivity groups, with disparities arising between normal-weight and overweight children. Cystatin isoforms A, B and SA were observed to be considerably increased in saliva from obese children. Conclusions Salivary proteome is related with sensitivities to bitter and sweet tastes in children, but the association is dependent on BMI percentile and gender.

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Estimation of salivary immunoglobulin A levels in gingivitis and chronic periodontitis patients before and after phase I periodontal therapy

Cited by 2 publications

References 0 publications

IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study

Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index

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