Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population

Saddiwal, Rashmi; Hebbale, Manjula; Sane, Vikrant Dilip; Hiremutt, Darshan; Gupta, Rohan; Merchant, Yash

doi:10.1007/s12663-016-0914-6

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…The study of Rupkar Pratic et al, (2016) indicated that serum level of β2M is a valuable diagnosis factor in the OLP and OSCC patients [17]. The results of their study are completely consistent with those of the present study.…”

Section: Discussionsupporting

confidence: 91%

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Salivary β2- microglobulin Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Nosratzehi

Alijani

et al. 2020

Preprint

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Objectiveβ2 microglobulin one of the biomarkers which are used to oral malignancy and pre-malignance lesion diagnosis. The components of the microglobulin system can help in growing and development of tumors directly or indirectly. The current study aims to evaluate the salivary β2- microglobulin level in malignance and pre-malignance lesion. The statistical population of research consists of 75 people which 25 people were healthy, 25 were infected by oral Lichen Planus (OLP) and remaining were infected by squamous cell carcinoma (SCC). The salivary data was performed by none –stimulated spitting method. The sample was performing during 9-12 AM and samples were transmitted to the laboratory immediately and salivary beta2microglobin was recorded based on the factory instructions by ELISA optical density method with 45Nm wavelength for each sample. Data analysis was performed by SPSS 24 software and ANOVA and post-hoc least significant difference (LSD) test.ResultsThe salivary β2 microglobulin level in squamous cell carcinoma (SCC) and oral lichen plan (OLP) patient is significantly higher than the healthy group. Therefore, we can use this index as a modern treatment protocol for malignancy and a pre-malignance oral lesion.

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Section: Discussionsupporting

confidence: 91%

“…Therefore, its application as a diagnostic fluid can be of special significance. Saliva is a diagnostic tool to assess markers due to its several advantages: a low-cost tool for monitoring, safe collection, non-invasive, convenient, simple and reproducible without causing discomfort for the patient [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Salivary β2- microglobulin Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Nosratzehi

Alijani

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The study of RupkarPratic et al, (2016) indicated that serum level of β2M is a valuablediagnosis factor in the OLP and OSCC patients [17]. The results of their study are completely consistentwith those of the present study.…”

Section: Discussionsupporting

confidence: 91%

“…Saliva is a diagnostic tool forassessing markers. It is advantageous because it is cheap for monitoring, safe for collecting, non-invasive, convenient, simple and reproducible, ;without causing discomfort tothe patient [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Salivary β2- microglobulin Levels in Patients with Erosive Oral Lichen Planus and Squamous Cell Carcinoma

Nosratzehi

Alijani

et al. 2020

Preprint

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Obectives: β2 microglobulin, as a biomarker, is used for the diagnosis oforal malignant and pre-malignant lesions. The components of the microglobulin system can directly or indirectly helpgrow and develop tumors. The present study aims to comparebeta-2 microglobulin levels in patients with lichen planus of the esophagus, oral squamous cell carcinoma, and healthy individuals. Further, it evaluated the salivaryβ2- microglobulin level in malignantand pre-malignant lesions. Oral lichen planus(OLP) is a chronic skin-mucus disorder. Of the total 75 patients referred to Oral Medicine at Dentistry School of Zahedan University of Medical Sciences, 25 were healthy and 25 had oral Lichen Planus(OLP) and the rest had squamous cell carcinoma(SCC). To collect the saliva samples, unstimulated spitting was used. They were collectedbetween 9 and 12 a.mSalivary beta2microglobin was recorded based on the factory instructions by ELISA optical density method with 450nm wavelength for each sample.The data were analyzed using descriptive, Kruskal-Wallis and Mann-Whitney and Pearson’s correlation coefficient (SPSS 21).Results: The salivary β2 microglobulin level in patients with squamous cell carcinoma(SCC) and oral lichen plan(OLP) is significantly higher than that inhealthy group. Thus, this index is usedfor assessing early malignant transformationand oral pre-malignantlesion.

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“…The increased production of B2M by carcinoma cells compared to non-neoplastic cells may be due to increased cell synthesis, breakdown, or both 19 . B2M levels have been reported to be significantly increased in individuals exposed to carcinogens, having premalignant conditions, at different stages of oral cancer and histological differentiation, when compared with healthy controls [20][21][22] . However, it has been shown that serum B2M is a superior diagnostic tool when compared to B2M level in saliva for OSCC 23 .…”

Section: Introductionmentioning

confidence: 99%

The Utility of Beta 2 Microglobulin (B2M) as an Initial Diagnostic Tool for Oral Squamous Cell Carcinoma (OSCC): Evidence from a Malaysian Scenario

Narayanan

Kassim

Liszen

et al. 2019

Bangladesh J Med Sci

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Background: The delay in diagnosis of oral squamous cell carcinoma (OSCC) is a factor in rendering the poor prognosis, and recent research has explored the use of serum tumour markers such Beta 2 Microglobulin (B2M), to aid early diagnosis. However, despite a high incidence of OSCC in Southeast Asia, no studies on the clinical use of B2M in the region were found. Objectives: To determine if serum B2M level can serve as an initial diagnostic tool to indicate if a biopsy is warranted, and if so, to propose a local B2M serum reference value to identify OSSC patients. Methodology: Twenty-one patients were seen at Hospital Universiti Sains Malaysia (HUSM) for a one-year period, between June 2016 and June 2017, and equal number of healthy controls participated in the study. Apart from patient history, venous blood of approximately 5ml volume was collected from each subject at the pre-treatment stage and analysed by an Abbot ARCHITECT c8000 analyser using the immunoturbidimetry method. The results were analysed using ROC analysis and the Mann Whitney test. Results: Serum B2M levels showed a statistically significant increase (p<0.001) in patients compared to controls. The test was shown to have 90.5% sensitivity and 90.5% specificity. It was found to be a sensitive and specific serum tumour marker at a cut off value of 1.57mg/l to differentiate cases from controls. Conclusion: B2M is a sensitive and specific tumour marker to differentiate OSCC cases from controls. It is cost effective and minimally invasive, making it a potentially useful adjunct diagnostic tool in a high-risk patient pool. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.729-735

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Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population

Cited by 12 publications

References 15 publications

Salivary β2- microglobulin Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Salivary β2- microglobulin Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Salivary β2- microglobulin Levels in Patients with Erosive Oral Lichen Planus and Squamous Cell Carcinoma

The Utility of Beta 2 Microglobulin (B2M) as an Initial Diagnostic Tool for Oral Squamous Cell Carcinoma (OSCC): Evidence from a Malaysian Scenario

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