Estimation of serum creatinine, serum urea, glomerular filtration rate and proteinuria among apparently healthy adults to assess the renal impairment and its association with body mass index: An observational hospital-based study

Ray, Amit Singh; Kare, Pawan Kumar; Makwane, Haresingh; Saxena, Tripti; Garg, Chitransh

doi:10.17511/ijmrr.2020.i02.09

Cited by 3 publications

(1 citation statement)

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“…Nada et al in 2015 observed that diabetic patients with higher BMI exhibited an elevation in RDW and a reduction in MCV level [17]. Ray SA et al in 2020 found that obese patients had higher levels of urea and creatinine, as well as lower estimated eGFR compared to normal-weight diabetic patients [18]. Another study by Okabayashi et al in 2020 concluded that obesityrelated glomerulonephropathy was associated with larger glomerular volume, lower glomerular density, and increased glomerulosclerosis, even with similar total nephrons.…”

Section: Dm First Report Dm Latest Report Diabetic Nephropathymentioning

confidence: 99%

Correlation between Red Cell Distribution Width (RDW) and Mean Corpuscular Volume (MCV) as a Prognostic Biomarker for Diabetic Nephropathy Patients in a South Indian Hospital

Anandhasayanam,

Kannan,

Hemanandhini

et al. 2024

J. Pharm. Res. Int.

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Context: Diabetic nephropathy is one of the microvascular complications of diabetes mellitus, capable of leading to end-stage renal disease. Diabetic nephropathy could only be identified through renal biopsy testing, which is expensive and can impose a financial burden on patients. Therefore, there is a necessity to develop a cost-effective method for identifying diabetic nephropathy. Aim: To evaluate the correlation between RBC parameters, such as RDW and MCV values, as prognostic biomarkers for patients with diabetic nephropathy. Methods and Material: Study Design: Prospective comparative study. Study Site: Sudha Institute of Medical Science, Erode. Study Duration: Study was carried out over six-months. Sample Size: 101 diabetic nephropathy patients and 101 type 2 diabetes mellitus patients. Statistical Analysis: Pearson correlation. Results: The majority of diabetic nephropathy patients were 40 years old or older, and most of them were males. Among the study participants, a significant number of male participants had habits of smoking and alcohol consumption. The duration of diabetes and BMI exhibited a strong correlation with the occurrence of diabetic nephropathy. Furthermore, there were notable increases in urea, creatinine, FBS, RBS, PPBS, and HbA1C, alongside a decrease in MCV and eGFR as diabetic nephropathy progressed. Conclusions: Our research indicates a positive correlation between RDW and HbA1c, FBS, RBS, PPBS, urea, and creatinine. In contrast, negative correlation of RDW with MCV and eGFR. MCV is negatively correlated with HbA1c, FBS, RBS, PPBS, urea, creatinine. In contrast, positive correlation between MCV and eGFR.

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Section: Dm First Report Dm Latest Report Diabetic Nephropathymentioning

confidence: 99%

Correlation between Red Cell Distribution Width (RDW) and Mean Corpuscular Volume (MCV) as a Prognostic Biomarker for Diabetic Nephropathy Patients in a South Indian Hospital

Anandhasayanam,

Kannan,

Hemanandhini

et al. 2024

J. Pharm. Res. Int.

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Evaluation of serum ferritin and hepcidin level and their association with obesity in Iraqi obese women

Sadiq

Jassim

2021

J. Phys.: Conf. Ser.

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Obesity is a chronic disease renowned as a global epidemic. Prevalence of obesity proceeded as highly elevated to almost two-thirds of the world population, including Iraq. One of the major reasons of overweight and obesity is increasing food intake. Obese people are often suffering from chronic inflammatory state due to a variation in immune efficiency in the adipose tissue. Our research aims to assess the ferritin and hepcidin level in obese women with and without hypertensive. Eighty of obese women were participants as volunteers, as well as, 40 subjects as healthy control. Based on Body Mass Index (BMI), Waist Circumference (WC), Waist to Height Ratio (WHtR) and Waist to Hip Ratio (WHpR). Participants were divided into two categories, the: first with BMI ≥ 18.5-25 kg/m2 as non-obese (control) and the, second with BMI ≥ 30kg/m2 as obese subjects. The studied parameters showed the following results: A significant elevation in TG, LDL, VLDL, glucose, AST, ALT, calcium, Creatinine, Uric acid, Urea, ferritin and hepcidin in obese (for both obese women and hypertensive obese women) compared with control group, while a significant decrease was noticed in HDL level in obese group as compared with control group. This study improved that ferritin and hepcidin can be considered as good markers to monitoring obesity, showing a high increase with increasing BMI.

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Serum ferritin level in type 2 diabetic patients with renal dysfunction

Goudappala

Sandhu

Krishnaiah

et al. 2022

IMC Journal of Medical Science

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Background and objective: Nephropathy is the major cause of end-stage renal disease (ESRD) in type 2 diabetes mellitus (T2DM). Delay in identification and management of nephropathy in T2DM may cause development of ESRD. An increased level of serum ferritin plays a role in the pathogenesis of chronic kidney disease (CKD) in T2DM. Hence, the present study intended to assess the level of serum ferritin in renal dysfunction in patients with T2DM. Material and methods: This was a retrospective study with 81 T2DM patients with and without nephropathy. They were categorized into two groups. Group-1 consisted of 46 T2DM cases without nephropathy and remaining 35 with nephropathy.The clinical and biochemical parameters such as blood glucose, urea, creatinine, iron, ferritin, transferrin, total iron binding capacity (TIBC), and haemoglobin were measured by standard methods, and estimated glomerular filtration rate (eGFR) by MDRD formula. Results: Significantly (p<0.05) elevated level of serum ferritin along with urea and creatinine was found in patients with T2DM with nephropathy.A significant positive correlation (r = 0.37) of serum ferritin and negative correlation (r = - 0.852) of eGFR with creatinine were found. It indicated that ferritin could be a good marker to monitor kidney function in T2DM. Conclusion: Apart from eGFR and serum creatinine, raised serum ferritin level was a good indicator of renal dysfunction in T2DM patients and might play an important role in renal dysfunction in early stage diabetic nephropathy. IMC J Med Sci 2022; 16(2): 008. DOI: https://doi.org/10.55010/imcjms.16.018 *Correspondence: Dr. Siva Prasad Palem., M.Sc., Ph.D., Department of Biochemistry, Faculty of Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar-505001, Telangana, India. Affiliated with Kaloji Narayana Rao University of Health Sciences (KNRUHS), Warangal, Telangana, India. E-mail: sp.biocom@yahoo.co.in.

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Estimation of serum creatinine, serum urea, glomerular filtration rate and proteinuria among apparently healthy adults to assess the renal impairment and its association with body mass index: An observational hospital-based study

Cited by 3 publications

References 0 publications

Correlation between Red Cell Distribution Width (RDW) and Mean Corpuscular Volume (MCV) as a Prognostic Biomarker for Diabetic Nephropathy Patients in a South Indian Hospital

Correlation between Red Cell Distribution Width (RDW) and Mean Corpuscular Volume (MCV) as a Prognostic Biomarker for Diabetic Nephropathy Patients in a South Indian Hospital

Evaluation of serum ferritin and hepcidin level and their association with obesity in Iraqi obese women

Serum ferritin level in type 2 diabetic patients with renal dysfunction

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