The rupturing of steam generator tubes leads to serious accidents in nuclear power plants. It causes radioactive materials to leak into the secondary system and release outside the reactor containment region. Therefore, it is important to model a technique to determine whether the natural circulation within a reactor coolant system (RCS) can cause rupture. In this study, a computational fluid dynamics (CFD) analysis methodology was incorporated as a first step to establish an RCS natural circulation evaluation technique to generate RCS natural circulation input parameters for the MELCOR analysis of thermally induced steam generator tube rupture (TI-SGTR) in nuclear power plants. Benchmarking tests were conducted against existing experimental studies; the results demonstrated a difference of 9.4% or less between the experimental and CFD analysis results with respect to the main evaluation factors. Subsequently, a steam generator tube simplification modeling technique was established for application to nuclear power plants, and CFD analysis was conducted to determine its applicability. The CFD analysis results revealed that when numerous tubes are simplified into one equivalent tube, the thermal flow characteristics generated in the RCS could be distorted. The findings of this research are expected to be helpful in understanding the thermal flow characteristics of natural circulation in the RCS. Further, the findings may potentially serve as a foundation for future CFD analysis research related to the natural circulation in the RCS of nuclear power plants.