“…Studies have used a range of exercise modalities, with cycling the most common mode employed (Yamamoto et al, 1991; Radaelli et al, 1996; Tulppo et al, 1996, 1998; Hautala et al, 2003; Casties et al, 2006; Cottin et al, 2006; Karapetian et al, 2008; Martinmaki and Rusko, 2008; Martinmaki et al, 2008), although walking/running has also been utilized (Hautala et al, 2003; Cottin et al, 2007; Botek et al, 2010; Kaikkonen et al, 2010). Other modes less commonly used are arm-cranking (Tulppo et al, 1999; Leicht et al, 2008), rowing (Cheng et al, 2005) and swimming (Di Michele et al, 2012). Regarding the effect of exercise dose factors (intensity, duration, and modality), intensity has received the most investigative attention, while fewer studies have investigated the effects of duration and modality.…”