ESTIMATION OF THE CARDIAC GLYCOSIDAL–CONTENTS OF<i>ADONIS AUTUMNALIS</i>LINN. AND<i>ADONIS DENTATA</i>DEL.

Ma, Elkiey; Sayed,; Sm, Abdel-Wahab; Soliman, FM

doi:10.1055/s-0028-1099973

Cited by 13 publications

(8 citation statements)

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“…Adonis species contain a mixture of cardiac glycosides, including adonitoxin, strophanthin, vernadigin, and cymarin. 2,5 Strophanthidin, the aglycone of several cardenolides present in adonis species, was detected in the stomach and cecal contents from the first two horses that died 24-48 hours after initial exposure to the hay and only in the cecal contents of the third horse that died 4 days later. Strophanthidin was not detected in the stomach contents of the third horse that died 4 days after initial exposure likely because of movement of the ingesta down the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Summer Pheasant's Eye (Adonis aestivalis) Poisoning in Three Horses

et al. 2004

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Abstract. Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented with signs of colic 24-48 hours after first exposure to the hay. Gastrointestinal gaseous distension was the primary finding on clinical examination of all three horses. Two horses became moribund and were euthanatized 1 day after first showing clinical signs, and the third horse was euthanatized after 4 days of medical therapy. Endocardial hemorrhage and gaseous distension of the gastrointestinal tract were the only necropsy findings in the first two horses. On microscopic examination, both horses had scattered foci of mild, acute myocardial necrosis and neutrophilic inflammation associated with endocardial and epicardial hemorrhage. The third horse that survived for 4 days had multifocal to coalescing, irregular foci of acute, subacute, and chronic myocardial degeneration and necrosis. A. aestivalis (pheasant's eye, summer adonis) was identified in the hay. Strophanthidin, the aglycone of several cardenolides present in Adonis spp., was detected by liquid chromatography-mass spectrometrymass spectrometry in gastrointestinal contents from all three horses. Although Adonis spp. contain cardiac glycosides, cardiac lesions have not previously been described in livestock associated with consumption of adonis, and this is the first report of adonis toxicosis in North America.

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Section: Discussionmentioning

confidence: 99%

Summer Pheasant's Eye (Adonis aestivalis) Poisoning in Three Horses

et al. 2004

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“…Concentrations of these cardenolides are highest in leaves and fl owers, reaching levels of 1 mg or more of glycosides per gram d.w. of plant at the time of fruiting (Elkiey et al 1967). Concentrations are lower in fruits and lowest in stems and roots.…”

Section: Adonis Lmentioning

confidence: 96%

“…Stamens 15 -80; anthers yellow or purple -black; fi laments fi liform; staminodia absent. In another Disease Genesis-Species of Adonis contain a series of potent 23 -C cardenolides: adonitoxin (a mannoside of adonitoxigenin; = 19 -oxogitoxigenin), cymarin, and K-strophanthin (a mixture of glycosides of strophanthidin); and vernadigin (a glycoside of strophadogenin; = 16-hydroxystrophanthidin) (Shoppee 1964;Elkiey et al 1967;Singh and Rastogi 1970;Joubert 1989;Kopp et al 1992;Woods et al 2004) (Figure 62.12). Fruits achenes; aggregated; sessile; nearly globose; beaked.…”

Section: Adonis Lmentioning

confidence: 99%

Ranunculaceae Juss.

and¹,

Tyrl²

2012

Toxic Plants of North America

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“…Adonis species contain cardiac glycosides that can be acutely toxic to some animals (Maiden 1912, Degen 1932, Kingsbury 1964, Elkiey and others 1967, Joubert 1989, Burrows and Tyrl 2001, Knight and Walter 2001, Woods and others 2004). Natural toxicoses of Adonis speciesare well documented in horses and pigs (Kummer 1952, Davies and Whyte 1989, Woods and others 2004).…”

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confidence: 99%

Evaluation of the toxicity of Adonis aestivalis in sheep

et al. 2011

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To determine the toxicity of Adonis aestivalis (adonis) in sheep, adult Suffolk ewes were administered 1 per cent bodyweight adonis via surgically placed rumen cannulas in an acute, high-dose toxicity study, and 0.2 per cent bodyweight daily in a two-week, low-dose toxicity study. The ewes received cardiac examinations before dosing, 24 and 48 hours after dosing with 1 per cent bodyweight adonis, and after continuous low-dose administration. All the ewes administered adonis had transient sinus arrhythmias after receiving 1 per cent bodyweight adonis. Two of the three ewes had transient reduced fractional shortening after administration with 1 per cent bodyweight adonis; the same two ewes had reduced fractional shortening after the low-dose treatment regimen. No gross or microscopic lesions were seen when the ewes were examined postmortem at the end of the study.

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ESTIMATION OF THE CARDIAC GLYCOSIDAL–CONTENTS OFADONIS AUTUMNALISLINN. ANDADONIS DENTATADEL.

Cited by 13 publications

References 0 publications

Summer Pheasant's Eye (Adonis aestivalis) Poisoning in Three Horses

Summer Pheasant's Eye (Adonis aestivalis) Poisoning in Three Horses

Ranunculaceae Juss.

Evaluation of the toxicity of Adonis aestivalis in sheep

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