“…Exposure to known risk factors such as radiation from diagnostic tests (Schonfeld et al, 2011), including the use of iodinated contrast agents (Baker and Bhatti, 2006) and medical imaging [dental radiography (Memon et al, 2010) and computed tomography scans (Baker and Bhatti, 2006)], radiotherapy for the treatment of the head and neck malignancies (Ron et al, 1995) and exposure to environmental ionizing radiation (Richardson, 2009), has been linked to thyroid cancer, and exposure to some of these factors has increased in the last decades (Mettler et al, 2008; United Nations Scientific Committee on the Effects of Atomic Radiation, 2010). In Portugal, specifically, estimates of radiodiagnosis in 2010 were twice those observed in 1992 (Serro et al, 1992;Teles et al, 2013). As thyroid cancer is much more common in women than men, a role of female hormones in thyroid cancer has been hypothesized; however, the evidence supporting a relation between reproductive factors such as age of menarche, menopause or number of pregnancies and this type of cancer (Rahbari et al, 2010) is still The mean number of cases per year is shown: for incidence, the number of cases from 3 years was used to increase the precision of estimates from Regional Cancer Registries with small numbers of cases (2007)(2008)(2009) was selected because it is the most recent period with data available from all Regional Cancer Registries); for mortality, the number of deaths from 8 years was used for each of the Portuguese regions (2004-2012 was selected to increase the precision of estimates for regions with very small numbers of cases).…”