Estimation of variance components for postpartum dysgalactia syndrome in sows

Preissler, R.; Hinrichs, Dirk; Reiners, Kerstin; Looft, H.; Kemper, Nicole

doi:10.1111/j.1439-0388.2011.00969.x

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…Frequency and severity of this complex disease appear to depend on immune competence including resistance to infection of the sow. While the heritability of CM resistance has been estimated in a range from 0.02 up to 0.20 [ 5 ], further genetic studies on mastitis susceptibility are lacking. Extremely low infectious dose for colonization of mammary gland of sows of less than 100 coliform microorganisms [ 6 ] abet microbial mammary tissue invasion.…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

Jaeger

Bardehle

Oster

et al. 2015

Vet Res

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Postpartum Dysgalactia Syndrome (PDS) represents a considerable health problem of postpartum sows, primarily indicated by mastitis and lactation failure. The poorly understood etiology of this multifactorial disease necessitates the use of the porcine mammary epithelial cell (PMEC) model to identify how and to what extent molecular pathogen defense mechanisms prevent bacterial infections at the first cellular barrier of the gland. PMEC were isolated from three lactating sows and challenged with heat-inactivated potential mastitis-causing pathogens Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) for 3 h and 24 h, in vitro. We focused on differential gene expression patterns of PMEC after pathogen challenge in comparison with the untreated control by performing microarray analysis. Our results show that a core innate immune response of PMEC is partly shared by E. coli and S. aureus. But E. coli infection induces much faster and stronger inflammatory response than S. aureus infection. An immediate and strong up-regulation of genes encoding cytokines (IL1A and IL8), chemokines (CCL2, CXCL1, CXCL2, CXCL3, and CXCL6) and cell adhesion molecules (VCAM1, ICAM1, and ITGB3) was explicitly obvious post-challenge with E. coli inducing a rapid recruitment and activation of cells of host defense mediated by IL1B and TNF signaling. In contrast, S. aureus infection rather induces the expression of genes encoding monooxygenases (CYP1A1, CYP3A4, and CYP1B1) initiating processes of detoxification and pathogen elimination. The results indicate that the course of PDS depends on the host recognition of different structural and pathogenic profiles first, which critically determines the extent and effectiveness of cellular immune defense after infection.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-015-0178-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

Jaeger

Bardehle

Oster

et al. 2015

Vet Res

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“…Nesse contexto, utilizando o bom senso em estimar possíveis agentes causais de hipertermia, associados, principalmente, às instalações e meio ambiente, alguns autores consideram "fêmeas problema" aquelas que não se alimentam e apresentam temperatura retal acima de 40,3°C (KLOPFENSTEIN et al, 1999). Outros trabalhos consideram "fêmeas problema" aquelas com temperatura igual ou superior a 39,5°C e que apresentam sinais clínicos ou alterações comportamentais relacionadas com a disgalactia (PREISSLER et al, 2012).…”

Section: Resultsunclassified

Índices produtivos de fêmeas suínas alimentadas com dietas de gestação e lactação suplementadas com óleos essenciais de orégano e alecrim: avaliação de leitegadas

Rossi

Soares

2013

Cienc. Rural

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Este estudo avaliou os índices produtivos de matrizes suínas alimentadas com dietas contendo uma mescla líquida de óleos essenciais. Foram utilizadas 250 matrizes de ordens de parto (OP) entre um a oito, com duas dietas experimentais na gestação e duas na lactação (dietas controle e com 200ppm de óleos essenciais). O delineamento experimental foi o de blocos ao acaso, em um arranjo fatorial 2x2 (tratamentos na gestação e na lactação) com as matrizes e leitegadas como unidade experimental. O peso vivo médio da leitegada ao desmame e o número de desmamados foram 8,0% e 3,8% superiores (P<0,05), respectivamente, para os leitões filhos de matrizes suplementadas com óleos essenciais. A temperatura corporal das fêmeas do controle e OP cinco, avaliadas no período pré-parto e durante o parto, foi 4,4% e 3,5% superiores (P<0,05) aos óleos essenciais, respectivamente. A adição de óleos essenciais na dieta de matrizes no final de gestação e no início da lactação aumentou o número de leitões desmamados e o peso de leitegada. As fêmeas suplementadas com óleos essenciais não apresentaram temperatura e sinais clínicos condizentes com disgalactia.

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“…,b,c; Preissler et al . ). The field observations and sample taking followed an approved animal care and use protocol.…”

Section: Methodsmentioning

confidence: 97%

A genome‐wide association study to detect genetic variation for postpartum dysgalactia syndrome in five commercial pig breeding lines

Preissler

Tetens

Reiners³

et al. 2013

Animal Genetics

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Postpartum dysgalactia syndrome (PDS) in sows is an important disease after parturition with a relevant economic impact, affecting the health and welfare of both sows and piglets. The genetic background of this disease has been discussed and its heritability estimated, but further genetic analyses are lacking in detail. The aim of the current study was to detect loci affecting the susceptibility to PDS through a genome-wide association approach. The study was designed as a family-based association study with matched sampling of affected sows and healthy half- or full-sib control sows on six farms. For the study, 597 sows (322 affected vs. 275 healthy control sows) were genotyped on 62 163 single nucleotide polymorphisms (SNPs) using the Illumina PorcineSNP60 BeadChip. After quality control, 585 sows (314 affected vs. 271 healthy control sows) and 49 740 SNPs remained for further analysis. Statistics were performed mainly with the r package genabel and included a principal component analysis. A statistically significant genome-wide associated SNP was identified on porcine chromosome (SSC) 17. Further promising results with moderate significance were detected on SSC 13 and on an unplaced scaffold with an older annotation on SSC 15. The PRICKLE2 and NRP2 genes were identified as candidate genes near associated SNPs. Several quantitative trait loci (QTL) have been previously described in these genomic regions, including QTL for mammary gland condition, as teat number and non-functional nipples QTL, as well as QTL for body temperature and gestation length.

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Estimation of variance components for postpartum dysgalactia syndrome in sows

Cited by 14 publications

References 15 publications

Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

Índices produtivos de fêmeas suínas alimentadas com dietas de gestação e lactação suplementadas com óleos essenciais de orégano e alecrim: avaliação de leitegadas

A genome‐wide association study to detect genetic variation for postpartum dysgalactia syndrome in five commercial pig breeding lines

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