Maritime traffic has increased considerably in recent years, making energy efficiency and navigation safety of ships more crucial than ever. Hence, a two-time scale model based on the Taylor expansion boundary element method (TEBEM) is proposed to predict ship turning trajectories in regular waves. The maneuvering motion is calculated using a three degrees of freedom MMG model that considers the wave drift loads. TEBEM overcomes the shortcomings of the constant panel method in solving tangential induced velocity at a non-smooth boundary and that of the high-order boundary element method in dealing with a high-order derivative of the velocity potential at the corner. This significantly improves the calculation accuracy of the induced velocity and high-order derivative of velocity potential. Firstly, based on the TEBEM, the surge and sway wave drift forces and yaw moment of the KVLCC2 model with drift angle under full wave headings are calculated and compared with computational fluid dynamics results, using which the calculation accuracy of TEBEM is verified. Subsequently, the two-time scale model is used to calculate the turning trajectories of the KVLCC2 model in regular waves with different wave headings, wave frequencies, and wave steepness. The numerical results show that the drift angle has a certain effect on the wave drift loads of the ship, and the proposed model can effectively predict the ship’s turning motion in regular waves.