Estradiol and progesterone binding in human term placental cytosol

Younes, M.A.; Besch, Norma F.; Besch, Paige K.

doi:10.1016/s0002-9378(16)32586-8

Cited by 48 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, recent reports describing the effects of progesterone on the expression of chorionic gonadotrophin (CG) α and β subunit genes in the human placenta (Rao et al, 1995) and corticotrophin releasing hormone (CRH) gene in human trophoblast cell cultures (Karalis et al, 1996) provide sufficient evidence to suggest that placenta itself can be a target tissue for the action of progesterone, though it has not been possible to accept this suggestion with certainity due to several conflicting reports in the literature (McCormick et al, 1981;Younes et al, 1981;Rivera and Cano, 1989;Padayachi et al, 1990;Karalis et al, 1996). Although it has been reported (Karalis et al, 1996) that human PR immunoreactivity could not be detected in trophoblast cells isolated from term placenta, studies (Rossmanith et al, 1997) as well as our own provide definitive evidence for the presence of PR in the human placenta.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the uterus, the placenta itself has been suggested to be a target tissue for the action of progesterone. However, there has been no conclusive evidence for the presence of progesterone receptors (PR) in the human placenta (McCormick et al, 1981;Younes et al, 1981;Rivera and Cano, 1989;Padayachi et al, 1990;Karalis et al, 1996). This has mainly been due to the techniques employed, particularly the nuclear exchange assay, the application of which to human placenta poses considerable problems because of the high endogenous concentration of progesterone.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Progesterone receptor expression in the human placenta

Shanker

Rao

1999

Molecular Human Reproduction

View full text Add to dashboard Cite

The presence of progesterone receptors (PR) in the human placenta has been demonstrated using the reverse transcriptase-polymerase chain reaction technique. It was observed that the amount of PR in the human placenta is less during late gestation. Electrophoretic mobility shift assays with nuclear extract isolated from the first trimester and term placenta revealed three complexes when incubated with [ 32 P]dCTP-labelled progesterone response element, and, in competition with unlabelled progesterone response element, the formation of all three complexes was inhibited. When supershift analysis of these complexes was carried out using antibodies which cross-react with both the A and B types of the PR or only with the B type receptor, only the A-form of PR was detected in the human placenta.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Progesterone receptor expression in the human placenta

Shanker

Rao

1999

Molecular Human Reproduction

View full text Add to dashboard Cite

show abstract

“…12,13 From the perspective of the period under the effect of estrogen produced by placenta, some histologic differences in the anterior pituitary may present due to the duration of pregnancy.…”

mentioning

confidence: 99%

T1 Signal Intensity and Height of the Anterior Pituitary in Neonates: Correlation with Postnatal Time

Kitamura¹,

Miki²,

Kawai³

et al. 2008

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:The anterior pituitary of a term neonate is usually hyperintense on T1-weighted MR images, which may represent histologic changes of the gland due to the effect of high estrogen levels during the fetal period; however, MR findings of a preterm neonate have not been fully evaluated. The purpose of this study was to investigate whether intensity and size of the neonatal anterior pituitary on MR images obtained near term of corrected age correlates with the gestational age at birth or postnatal time.

show abstract

“…The results are conflicting [15][16][17][18], Up to now we have found only one preliminary and incomplete study on the presence of ER and PR in first-trimester cho rion villosum [19].…”

Section: Discussionmentioning

confidence: 96%

Chorion Villosum Does Not Express Progesterone and Estrogen Receptors during the First Trimester of Pregnancy

Taddei

Noci²,

Periti³

et al. 1996

Gynecol Obstet Invest

View full text Add to dashboard Cite

First-trimester chorion villosum plays the key role in the development of human placenta and secretes a large number of hormones and hormone-related substances. To test whether progesterone and estrogen could have regulatory effects on first-trimester chorion villosum functions, we investigated the presence of progesterone receptor (PR) and estrogen receptor (ER) in 47 chorion villosum samples from patients who underwent abortion during the first trimester of pregnancy. The study was carried out using immunohistochemical methods. No ER and PR positivity was evidenced in the 47 chorion villosum samples examined. The possibility that progesterone and estrogen play a role in the regulation of chorion villosum functions should therefore be excluded.

show abstract

Estradiol and progesterone binding in human term placental cytosol

Cited by 48 publications

References 21 publications

Progesterone receptor expression in the human placenta

Progesterone receptor expression in the human placenta

T1 Signal Intensity and Height of the Anterior Pituitary in Neonates: Correlation with Postnatal Time

Chorion Villosum Does Not Express Progesterone and Estrogen Receptors during the First Trimester of Pregnancy

Contact Info

Product

Resources

About