Estradiol Biosynthesis in Canine Lens Epithelial Cells

Colitz, Carmen M.H.; Lü, Ping; Sugimoto, Yasuro; Barden, C.A.; Chandler, Heather L.

doi:10.3109/02713683.2014.935446

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Raape et al have speculated that a high amount of estrogen produced in the eye provides a favorable niche for breast cancer metastases, and more specifically ILC [17]. This hypothesis is supported by reports of high ER expression in the retina, lens ciliary body, and iris [32] and high aromatase expression in the lens epithelial cells [33]. However, 15% of the OM in our cohort arose from ER-negative primary tumors, demonstrating the need for further investigation of this hypothesis through analysis of additional clinical samples, and mechanistic analyses.…”

Section: Discussionmentioning

confidence: 93%

Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology

et al. 2020

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Background: Breast cancer is the most common malignancy to spread to the orbit and periorbit, and the invasive lobular carcinoma (ILC) histologic subtype of breast cancer has been reported to form these ophthalmic metastases (OM) more frequently than invasive ductal carcinomas (IDC). We herein report our single academic institution experience with breast cancer OM with respect to anatomical presentation, histology (lobular vs. ductal), treatment, and survival. Methods: We employed the natural language processing platform, TIES (Text Information Extraction System), to search 2.3 million de-identified patient pathology and radiology records at our institution in order to identify patients with OM secondary to breast cancer. We then compared the resultant cohort, the "OM cohort," to two other representative metastatic breast cancer patient (MBC) databases from our institution. Histological analysis of selected patients was performed.

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Section: Discussionmentioning

confidence: 93%

Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology

et al. 2020

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“…However a study by Colitz et al, [71] showed that cataractous lens epithelial cells overexpress estrogen receptors and the authors posited that these cells may become estrogen sensitive during caractogenesis. Furthermore, lens epithelia have the aromatase pathway enabling conversion of testosterone to estradiol [72]. This would indicate a greater risk associated with intact dogs of both sexes.…”

Section: Discussionmentioning

confidence: 99%

Correlation of neuter status and expression of heritable disorders

Belanger

Bellumori

Bannasch

et al. 2017

Canine Genet Epidemiol

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BackgroundGonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds.ResultsNeutered dogs were at less risk for early and congenital conditions (aortic stenosis, early onset cataracts, mitral valve disease, patent ductus arteriosus, portosystemic shunt, and ventricular septal defect) than intact dogs. Neutering was also associated with reduced risk of dilated cardiomyopathy and gastric dilatation volvulus in males. Neutering was significantly associated with an increased risk for males and females for cancers (hemangiosarcoma, hyperadrenocorticism, lymphoma, mast cell tumor, and osteosarcoma), ruptured anterior cruciate ligament and epilepsy. Intervertebral disk disease was associated with increased risk in females only. For elbow dysplasia, hip dysplasia, lens luxation, and patellar luxation neutering had no significant effect on the risk for those conditions. Neutering was associated with a reduced risk of vehicular injury, a condition chosen as a control.ConclusionsIn this retrospective study, several conditions showed an increased risk associated with neutering whereas other conditions were less likely to be expressed in neutered dogs. The complexity of the interactions between neutering and inherited conditions underscores the need for reflective consultation between the client and the clinician when considering neutering. The convenience and advantages of neutering dogs that will not be included in a breeding program must be weighed against possible risk associated with neutering.Electronic supplementary materialThe online version of this article (doi:10.1186/s40575-017-0044-6) contains supplementary material, which is available to authorized users.

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“…Furthermore, ESR1 has been shown to be expressed in human TM cells [ 53 ]. Moreover, the various isoforms of estrogen have been shown to be present in bovine, canine, rabbit, and human AH [ 54 , 55 , 56 , 57 ] as well as in human TM cells [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes

Youngblood

Parker

Cai

et al. 2021

IJMS

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Elevated intraocular pressure (IOP) is the only modifiable risk factor for primary open-angle glaucoma (POAG). Herein we sought to prioritize a set of previously identified IOP-associated genes using novel and previously published datasets. We identified several genes for future study, including several involved in cytoskeletal/extracellular matrix reorganization, cell adhesion, angiogenesis, and TGF-β signaling. Our differential correlation analysis of IOP-associated genes identified 295 pairs of 201 genes with differential correlation. Pathway analysis identified β-estradiol as the top upstream regulator of these genes with ESR1 mediating 25 interactions. Several genes (i.e., EFEMP1, FOXC1, and SPTBN1) regulated by β-estradiol/ESR1 were highly expressed in non-glaucomatous human trabecular meshwork (TM) or Schlemm’s canal (SC) cells and specifically expressed in TM/SC cell clusters defined by single-cell RNA-sequencing. We confirmed ESR1 gene and protein expression in human TM cells and TM/SC tissue with quantitative real-time PCR and immunofluorescence, respectively. 17β-estradiol was identified in bovine, porcine, and human aqueous humor (AH) using ELISA. In conclusion, we have identified estrogen receptor signaling as a key modulator of several IOP-associated genes. The expression of ESR1 and these IOP-associated genes in TM/SC tissue and the presence of 17β-estradiol in AH supports a role for estrogen signaling in IOP regulation.

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Estradiol Biosynthesis in Canine Lens Epithelial Cells

Cited by 4 publications

References 19 publications

Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology

Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology

Correlation of neuter status and expression of heritable disorders

Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes

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