Estradiol‐mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKα, and miR‐221

Panic, Anastasija; Stanimirović, Julijana; Obradović, Milan; Sudar-Milovanović, Emina; Perović, Milan; Lačković, Milena; Petrović, Nina; Isenović, Esma R.

doi:10.1002/bab.1680

Cited by 8 publications

(3 citation statements)

References 91 publications

(107 reference statements)

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“…In support of this hypothesis, studies in rodents suggested that these observed deleterious aging-related effects on females’ livers might be attributed to impaired lipid metabolism. In fact, in these models, estrogens increased fatty acid β-oxidation by AMPK activation [32,33]. Taking together these studies, it could be speculated that in menopausal women, lower serum estrogen levels might constitute a major cause for impaired lipid accumulation/break down balance and therefore for the promotion of NAFLD development.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

et al. 2019

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Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and evolve to hepatic cirrhosis or hepatic carcinoma. Oxidative stress, lipotoxicity, and inflammation play a key role in the progression of NAFLD. A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Here, we performed a systematic review of clinical trials analyzing the efficacy of n-3 PUFA on both systemic oxidative stress and on NAFLD/NASH features in adults. As a matter of fact, it remains controversial whether n-3 PUFA are effective to counteract oxidative stress. On the other hand, data suggest that n-3 PUFA supplementation may be effective in the early stages of NAFLD, but not in patients with more severe NAFLD or NASH. Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

et al. 2019

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“…Obesity is a foremost underlying risk factor of several chronic diseases, including metabolic syndrome (MS), T2DM, cardiovascular diseases, fatty liver diseases, and cancer [16][17][18][19][20][21][22][23][24], all of which share a common pathological condition, insulin resistance (IR) [25]. Fat accumulation in the visceral tissues and organs in obesity leads to free fatty acids (FFAs) release into the portal circulation and further impairment of glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress in obesity and insulin resistance

Panic

Stanimirović

Sudar-Milovanović

et al. 2022

Exploration of Medicine

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Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published literature to collate and provide a comprehensive summary of the studies related to the status of the OxS in the pathogenesis of obesity and related IR. OxS represents an imbalance between the production of reactive oxygen and nitrogen species (RONS) and the capacity of the antioxidant defense system (AOS) to neutralize RONS. A steady-state of RONS level is maintained through endogenous enzymatic and non-enzymatic AOS components. Three crucial enzymes, which suppress the formation of free radicals, are superoxide dismutases, catalases, and glutathione peroxidases. The second line of AOS includes non-enzymatic components such as vitamins C and E, coenzyme Q, and glutathione which neutralizes free radicals by donating electrons to RONS. Emerging evidence suggests that high RONS levels contribute to the progression of OxS in obesity by activating inflammatory pathways and thus leading to the development of pathological states, including IR. In addition, decreased level of AOS components in obesity increases the susceptibility to oxidative tissue damage and further progression of its comorbidities. Increased OxS in accumulated adipose tissue should be an imperative target for developing new therapies in obesity-related IR.

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“…It is considered that the spread of NAFLD in the coming decade may increase, and by 2030, it will be the most common reason of liver transplantation [4]. NAFLD is the most prevalent chronic liver disease (CLD) [5] and includes a set of different histological features from simple steatosis to nonalcoholic steatohepatitis (NASH), that finally leads to cirrhosis and hepatocellular carcinoma [6]. Despite the fact that NAFLD is powerfully related with insulin resistance and obesity, its pathogenesis has not been explained clearly [7].…”

Section: Introductionmentioning

confidence: 99%

Circulating mRNA and plasma levels of osteoprotegerin and receptor activator of NF‐κB ligand in nonalcoholic fatty liver disease

Nikseresht

Azarmehr

Arya

et al. 2020

Biotechnology and Applied Biochemistry

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Pathogenesis of the beginning and progression of nonalcoholic fatty liver disease (NAFLD) has not been clarified exactly. The osteoprotegerin (OPG)/receptor activator of NF-κB ligand (RANKL) axis seems to play an imperative function in the onset and progression of this disease. The goal of the present study was to investigate the peripheral blood mononuclear cell (PBMC) expression and plasma levels of RANKL and OPG cytokines in NAFLD patients and compare them with healthy group. Plasma levels of OPG and RANKL were determined with ELISA kits in 57 men with NAFLD and 25 healthy men as controls. Biochemical and anthropometric parameters tests were also evaluated in the study groups. RANKL and OPG mRNA contents were evaluated by quantitative RT-PCR. OPG contents were markedly decreased in NAFLD patients as compared with healthy patients [1.43 (1.05-5.45)] versus [2.94 (1.76-4.73)] ng/mL; P = 0.007). The levels of RANKL were significantly reduced in NAFLD patients [74.00 (56.26-203.52) ng/mL] than in healthy patients [119.37 (83.71-150.13) ng/mL]; (P = 0.03). Also, OPG and RANKL gene expression were significantly decreased in NAFLD patients in comparison with the control group (P < 0.05). Moreover, receiver operating characteristic curve indicated that OPG may have a good capability to discriminate between NAFLD patients and normal individuals. A positive correlation was observed between OPG and RANKL in plasma sample (r = 0.495) (P = 0.000). Decreased plasma levels and gene expression of RANKL and OPG cytokines in NAFLD patients indicate that there is a relationship between these cytokines and the pathology of NAFLD disease. Confirmation of this association as well as the mechanism and role of these cytokines in NAFLD require further studies.

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Estradiol‐mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKα, and miR‐221

Cited by 8 publications

References 91 publications

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

Oxidative stress in obesity and insulin resistance

Circulating mRNA and plasma levels of osteoprotegerin and receptor activator of NF‐κB ligand in nonalcoholic fatty liver disease

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