Estradiol replacement enhances sleep deprivation-induced c-Fos immunoreactivity in forebrain arousal regions of ovariectomized rats

Deurveilher, Samüel; Cumyn, Elizabeth M.; Peers, T.; Rusak, Benjamin; Semba, Kazue

doi:10.1152/ajpregu.90576.2008

Cited by 33 publications

(25 citation statements)

References 76 publications

(101 reference statements)

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“…The wake-promoting hypocretin system has recently been shown to be highly sensitive to fluctuations in endogenous and exogenous ovarian steroids (54,55). E2 also increases wake-associated Fos expression in hypocretin neurons and in the histaminergic tuberomammillary nuclei (15), while decreasing Fos expression in the sleep-active ventrolateral preoptic area (15,22). Thus exogenous E2 may influence sleep-wake state via coordinated action in multiple cell groups that modulate sleep-wake state in distinct ways.…”

Section: Discussionmentioning

confidence: 99%

“…Baseline vigilance state data (REM, NREM, wake duration) and NREM delta power were analyzed by a repeated-measures ANOVA comparing hormone treatment (EB ϫ oil) by time (ZT 0, 3,6,9,12,15,18,21) in Statistica (Statsoft; Tulsa, OK). Recovery sleep and delta power were analyzed by a repeated-measures ANOVA comparing hormone treatment by time of day (experiment 1, ZT 6,9,12,15,18,21; experiment 2, ZT 12,15,18,21,0,3).…”

Section: Animalsmentioning

confidence: 99%

“…Recovery sleep and delta power were analyzed by a repeated-measures ANOVA comparing hormone treatment by time of day (experiment 1, ZT 6,9,12,15,18,21; experiment 2, ZT 12,15,18,21,0,3). Sleep bout numbers and average bout length were analyzed by a repeated-measures ANOVA comparing hormone treatment by time of day (L vs. D).…”

Section: Animalsmentioning

confidence: 99%

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Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner

Schwartz

Mong

2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Ovarian hormones are thought to modulate sleep and fluctuations in the hormonal milieu are coincident with sleep complaints in women. In female rats, estradiol increases waking and suppresses sleep. In this study, we asked whether this effect is mediated via circadian or homeostatic regulatory mechanisms. Ovariectomized female rats received daily injections of estradiol benzoate (EB) or sesame oil that mimicked the rapid increase and subsequent decline of circulating estradiol at proestrus. In one experiment, animals were sleep deprived for 6 h starting at lights-on, so that recovery began in the mid-light phase; in the second experiment, animals were sleep deprived starting in the mid-light phase, so that recovery began at lights-off. EB suppressed baseline rapid eye movement (REM) and non-REM (NREM) sleep and increased waking in the dark phase. In both experiments, EB enhanced REM recovery in the light phase while suppressing it in the dark compared with oil; this effect was most pronounced in the first 6 h of recovery. By contrast, NREM recovery was largely unaffected by EB. In summary, EB enhanced waking and suppressed sleep, particularly REM sleep, in the dark under baseline and recovery conditions. These strong temporally dependent effects suggest that EB consolidates circadian sleep-wake rhythms in female rats.

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Section: Discussionmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

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Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner

Schwartz

Mong

2013

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Estrogen and progesterone receptors are localized in many sleep/wake-regulatory nuclei, including the basal forebrain, hypothalamus, dorsal raphe nucleus, and locus coeruleus (Shughrue et al, 1997; Curran-Rauhut and Petersen, 2002), and estradiol modulates sleep deprivation-induced neuronal activation as measured by FOS protein expression in these areas (Peterfi et al, 2004; Deurveilher et al, 2008). …”

Section: What Animal Models Can Tell Us About Gonadal Influences and mentioning

confidence: 99%

Sleep, Rhythms, and the Endocrine Brain: Influence of Sex and Gonadal Hormones

Mong¹,

Baker²,

Mahoney³

et al. 2011

J. Neurosci.

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251

176

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While much is known about the mechanisms that underlie sleep and circadian rhythms, the investigation into sex differences and gonadal steroid modulation of sleep and biological rhythms is in its infancy. There is a growing recognition of sex disparities in sleep and rhythm disorders. Understanding how neuroendocrine mediators and sex differences influence sleep and biological rhythms is central to advancing our understanding of sleep-related disorders. While it is known that ovarian steroids affect circadian rhythms in rodents, the role of androgen is less understood. Surprising findings that androgens, acting via androgen receptors in the master “circadian clock” within the suprachiasmatic nucleus (SCN), modulate photic effects on activity in males points to novel mechanisms of circadian control. Work in aromatase deficient (ArKO) mice suggests that some sex differences in photic responsiveness are independent of gonadal hormone effects during development. In parallel, aspects of sex differences in sleep are also reported to be independent of gonadal steroids and may involve sex chromosome complement. This a summary of recent work illustrating how sex differences and gonadal hormones influence sleep and circadian rhythms that was presented at a mini-symposium at the 2011 annual meeting of the Society for Neuroscience.

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“…This dose of estrogen used here could raise its concentration to proestrus levels in blood which is sufficient to induce physiological responses such as increase of uterine weight and c-Fos expression in the brain as a marker of neuronal activation [15]. Poly(A)+ RNAs were isolated from the hippocampus of these animals 8 h after estrogen injection and subjected to microarray analysis using Affymetrix Rat Neurobiology U34 array, which contains over 1,200 sequences relevant to the study of neurobiology.…”

Section: Identification Of Genes Regulated By Estrogen In Rat Hippocamentioning

confidence: 99%

Identification of Igf2, Igfbp2 and Enpp2 as Estrogen-Responsive Genes in Rat Hippocampus

et al. 2009

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Abstract. Estrogen has an important effect on higher brain function such as memory, learning, and emotion in which the hippocampus plays a critical role. The hippocampus expresses estrogen receptors, ERα and ERβ, which are liganddependent transcription factors; however, the precise mechanism of estrogen action is not fully understood. We explored genes which are up-regulated by estrogen in the hippocampus using ovariectomized rat models. Microarray analysis revealed that mRNA levels of ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), insulin like growth factor 2 (Igf2) and insulin-like growth factor binding protein 2 (Igfbp2) were increased by estrogen in the hippocampus. Quantitative-PCR analysis demonstrated that the levels of Enpp2, Igf2 and Igfbp2 mRNA were elevated by estrogen administration in the hippocampus but not in the hypothalamus. On the other hand, ERα, ERβ and progesterone receptor (PR) mRNA expression was up-regulated by estrogen only in the hypothalamus. We further analyzed the time-dependent regulation of these genes using rat pituitary adenoma, MtT/S and GH3 cells, which are known to express ERα. In both MtT/S and GH3 cells, Igfbp2 and Enpp2 mRNAs were up-and down-regulated by estrogen, respectively, whereas Igf2 mRNA was increased only in GH3 cells. These results demonstrate a brain region-and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus.

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Estradiol replacement enhances sleep deprivation-induced c-Fos immunoreactivity in forebrain arousal regions of ovariectomized rats

Cited by 33 publications

References 76 publications

Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner

Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner

Sleep, Rhythms, and the Endocrine Brain: Influence of Sex and Gonadal Hormones

Identification of Igf2, Igfbp2 and Enpp2 as Estrogen-Responsive Genes in Rat Hippocampus

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