Estradiol/testosterone and estradiol/androstenedione indexes and nutritional status in PCOS women – A pilot study

Franik, Grzegorz; Maksym, Marta; Owczarek, Aleksander; Chudek, Jerzy; Madej, Paweł; Olszanecka-Glinianowicz, Magdalena

doi:10.1016/j.ejogrb.2019.05.045

Cited by 19 publications

(10 citation statements)

References 17 publications

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“…For instance, it was reported that almost 50% of the patients with PCOS had elevated circulating levels of DHEAS and that the combinational measurements of T and DHEAS were superior to the conventional serum T alone in hyperandrogenism evaluation 9,29,30 . Furthermore, as the immediate precursor of T in its biological synthesis, 31,32 A4 accumulation was also considered as a type of androgen excess 11,33 . A prospective study showed that the diagnosis of PCOS could be increased by about 9% if A4 was included in the androgen panel 34 .…”

Section: Discussionmentioning

confidence: 99%

Simultaneous quantitation of four androgens and 17‐hydroxyprogesterone in polycystic ovarian syndrome patients by LC‐MS/MS

Cao

Cong³

et al. 2020

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Simultaneous quantitation of four androgens and 17‐hydroxyprogesterone in polycystic ovarian syndrome patients by LC‐MS/MS

Cao

Cong³

et al. 2020

Clinical Laboratory Analysis

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“…Abnormal hormone exposure in early pregnancy can affect metabolic status in adulthood. Most women with PCOS have unexplained high androgen levels during pregnancy ( 25 , 26 ), and their offspring will exhibit HA and metabolic disorders which are centered on IR in adulthood. Animal studies have shown that embryonic Adiponectin supplementation improves the metabolic syndrome in adult PCOS offspring by activating the PI3K-Akt pathway ( 27 ).…”

Section: Methodsmentioning

confidence: 99%

Progress of Adipokines in the Female Reproductive System: A Focus on Polycystic Ovary Syndrome

et al. 2022

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Adipose tissue, one type of loose connective tissue in the human body, maintains the primary task of energy storage. Adipose tissue is not only an energy reservoir but also plays a vital role as the largest endocrine organ of the whole body via releasing a variety of adipokines, which participate in many pathophysiological processes, such as energy metabolism regulation, glucose and lipid metabolism, and inflammation. Polycystic ovary syndrome (PCOS) is a disorder that mainly involves the female reproductive system, affecting women of childbearing age particularly. Insulin resistance (IR) and hyperandrogenemia (HA) have been implicated as a critical link involving the etiology and outcome of PCOS. A great deal of studies has bridged the gap between adipokines (such as Adiponectin, Chemerin, Metrnl, Apelin, Resistin, Visfatin, Leptin, Vaspin, Lipocalin 2, and Omentin) and reproductive fitness. In this review, we will focus on the adipokines’ functions on PCOS and come up with some points of view on the basis of current research.

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“…Inappropriate hormone exposure during the early pregnancy, which is a sensitive period for different organizations or systems, including the central nervous system, heart, liver, and reproductive organs, can induce large metabolic alterations in adult life, and most women with PCOS have unexplained hyperandrogenic levels during pregnancy [35,36]. Cimino I et al confirmed that the increased binding of GABA and GnRH neurons in the offspring caused by hyperandrogenemia during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Effects of exogenous adiponectin supplementation in early pregnant PCOS mice on the metabolic syndrome of adult female offspring

et al. 2021

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Objective PCOS is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities. At present, PCOS has been confirmed to have a certain genetic background. Compared with healthy women, the vast majority of PCOS patients have hyperandrogenemia, and this excessive androgen exposure during pregnancy may affect the development of female fetuses. The aim of the current study was to investigate the effect of adiponectin intervention during early pregnancy of obese mice with PCOS on the metabolic phenotype of adult female offspring. Methods After the PCOS model was established, C57BL/6J mice were divided into maternal-control, maternal-PCOS, and maternal-PCOS + APN groups. DHEA-induced PCOS mice were supplemented with adiponectin (10 mg/kg/day) in the early pregnancy in order to eliminate adverse hormone exposure and then traced for endocrine indicators in their adult female offspring, which were observed for metabolism syndrome or endocrine disturbance and exhibited the main effects of APN. To further explore the underlying mechanism, the relative expressions of phosphorylated AMPK, PI3K, and Akt were detected in the ovaries of offspring mice. Results The serum testosterone level of the maternal-PCOS + APN group in early pregnancy was significantly lower than that of the maternal-PCOS group (p < 0.01). The serum testosterone level in the offspring-PCOS + APN group was significantly lower than in the offspring-PCOS group (p <0.05), the diestrus time characterized by massive granulocyte aggregation in the estrus cycle was significantly shorter than in the offspring-PCOS group (p<0.05), and the phenotypes of PCOS-like reproductive disorders and metabolic disorders, such as obesity, insulin resistance, impaired glucose tolerance, and hyperlipidemia, were also significantly improved in the offspring-PCOS + APN group (p < 0.05). Compared with the control group, the expression levels of phosphorylated AMPK, PI3K, and Akt in the offspring-PCOS group were significantly decreased (p < 0.05), while those in the offspring-PCOS + APN group were significantly increased (p < 0.05). Conclusions APN intervention in early pregnancy significantly reduced the adverse effects of maternal obesity and high androgen levels during pregnancy on female offspring and corrected the PCOS-like endocrine phenotype and metabolic disorders of adult female offspring. This effect may be caused by the activation of the AMPK/PI3K-Akt signaling pathway in PCOS offspring mice.

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Estradiol/testosterone and estradiol/androstenedione indexes and nutritional status in PCOS women – A pilot study

Cited by 19 publications

References 17 publications

Simultaneous quantitation of four androgens and 17‐hydroxyprogesterone in polycystic ovarian syndrome patients by LC‐MS/MS

Simultaneous quantitation of four androgens and 17‐hydroxyprogesterone in polycystic ovarian syndrome patients by LC‐MS/MS

Progress of Adipokines in the Female Reproductive System: A Focus on Polycystic Ovary Syndrome

Effects of exogenous adiponectin supplementation in early pregnant PCOS mice on the metabolic syndrome of adult female offspring

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