Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women

Bartholomeusz, Cali F.; Wesnes, Keith; Kulkarni, Jayashri; Vitetta, Luis; Croft, Rodney J.; Nathan, Pradeep J.

doi:10.1016/j.yhbeh.2008.07.007

Cited by 13 publications

(8 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pharmacological administration of estradiol in younger women led to a slight improvement in verbal memory in some studies (Bartholomeusz et al, 2008;Phillips and Sherwin, 1992a;Sherwin, 1998;Sherwin and Tulandi, 1996). Natural fluctuations in estradiol across the menstrual cycle are associated with fluctuations in verbal, emotional and spatial memory performance in some studies (Ertman et al, 2011;Solis-Ortiz and Corsi-Cabrera, 2008) in particular, menstrual cycle-dependent changes in verbal memory occurred simultaneously to changes in hippocampal volume (Protopopescu et al, 2008).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Vierk

Bayer

Freitag

et al. 2015

Hormones and Behavior

View full text Add to dashboard Cite

Section: Accepted Manuscriptmentioning

confidence: 99%

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Vierk

Bayer

Freitag

et al. 2015

Hormones and Behavior

View full text Add to dashboard Cite

“…Estrogen has long been known to influence several neurotransmitter systems, including those that are cholinergic (Luine, 1985; Dominguez et al, 2004; Kompoliti et al, 2004; Bora et al, 2005; Bartholomeusz et al, 2008; Ping et al, 2008), serotonergic (Kendall et al, 1981; Halbreich et al, 1995; Rubinow et al, 1998; Archer, 1999; Lasiuk and Hegadoren, 2007), adrenergic (Sar and Stumpf, 1981; Ungar et al, 1993; Wang et al, 2006), or dopaminergic (Roy et al, 1990). Hormones may act through inducing temporary changes in neuronal microstructure, such as dendritic spine formation (Woolley et al, 1990), affecting neurotransmitters and receptors (McEwen, 1981; Arnold and Breedlove, 1985; Meusburger and Keast, 2001), altering cell membranes (McEwen et al, 1991) and modifying cerebral glucose metabolism and blood flow (Namba and Sokoloff, 1984; Nehlig et al, 1985; Bishop and Simpkins, 1995; Eberling et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD

Silverman

Geist

Kenna

et al. 2011

Psychoneuroendocrinology

View full text Add to dashboard Cite

SummaryDifferential cerebral metabolic effects of various hormone therapy formulations, and their associations with cognitive status, remain to be established. The principal aim of the current study wasto assess relationships between regional cerebral metabolism and estrogen-based hormone therapies. Postmenopausal women (n=53) at elevated risk for Alzheimer's disease (AD) were on estrogen-containing hormone therapy for at least one year prior to enrollment in a prospective, randomized clinical trial. Subjects underwent an FDG-PET scan, along with neuropsychological, medical, and demographic assessments at time of enrollment, to be repeated one year following randomization to hormone therapy continuation versus discontinuation, and results from analyses of the baseline assessments are reported here. Across all subjects, years of endogenous estrogen exposure correlated most closely with metabolism in right superior frontal gyrus (p<0.0005). Women taking 17β-estradiol (E) performed 3 standard deviations higher in verbal memory than women taking conjugated equine estrogen (CEE), and their verbal memory performance positively correlated with metabolism in Wernicke's (p=0.003) and auditory association (p=0.002) areas. Women taking progesterone-plus-estrogen had lower metabolism than women taking unopposed estrogen within the mesial and inferior lateral temporal regions (p<0.0005) and the inferior frontal cortex, contralateral to Broca's area (p<0.0005). In conclusion, particular areas of relatively preserved metabolism were seen in women with more years of endogenous estrogen exposure, as well as in women taking estradiol-based formulations or estrogen therapies unopposed by progesterone, together suggesting regionally specific neuroprotective estrogenic effects.

show abstract

“…Dumas et al [6, 24] have shown that a slight impairment in cholinergic functioning using cholinergic antagonist challenge model is necessary to observe beneficial effects of estrogen on cognition. However, using a similar cholinergic challenge model, Bartholomeusz et al [25] found no benefit of estrogen on cognition in younger premenopausal women. Thus the relationship between estrogen and the cholinergic system remains to be further elucidated.…”

Section: Introductionmentioning

confidence: 99%

Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women

et al. 2010

View full text Add to dashboard Cite

Objective-The cholinergic system has been shown to modulate estrogen effects on cognitive performance in postmenopausal women. This pilot study investigated the effects of two receptorspecific anticholinergic drugs on brain activation and episodic memory encoding in postmenopausal women not taking estrogen in an effort to further understand cholinergic contributions to cognition after menopause.Method-Six healthy post-menopausal women took part in three drug challenges using the antimuscarinic drug scopolamine (SCOP, 2.5 µg/kg, IV), the antinicotinic drug mecamylamine (MECA, 20 mg, oral), and placebo. During fMRI subjects performed a visual-verbal continuous recognition memory test that allowed for the separation of encoding and recognition processes.Results-Functional MRI results showed greater hippocampal and frontal activation and less occipital activation during encoding relative to retrieval conditions. This pattern of activation was similar under both drug challenges.Conclusions-These results suggest that the changes in the cholinergic system may be in part responsible for menopause-related increases in brain activation.

show abstract

Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women

Cited by 13 publications

References 96 publications

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD

Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women

Contact Info

Product

Resources

About