Uso tópico de agente antifibrinolítico na redução do sangramento após revascularização cirúrgica do miocárdioTopical use of antifibrinolytic agent to reduce postoperative bleeding after coronary artery bypass surgery Abstract Objective: Antifibrinolytic agents reduce bleeding after cardiac surgery, but there are adverse effects after their systemic use. These effects are avoided by topical application of antifibrinolytic agents in pericardial cavity. We compared the effects of topically applied epsilon-aminocaproic acid (EACA) and placebo on postoperative bleeding and transfusion requirements after coronary artery bypass surgery.Methods: In this single center prospective, randomized, double-blind trial, 53 patients were randomized into two groups to receive EACA (24 g in 250 ml of saline solution) or placebo (250 ml of saline solution) before sternal closure. Groups were compared according the preoperative and intraoperative variables. Postoperative bleeding, transfusion requirements and hematologic parameters were evaluated.Results