Estrogen activity of terpenoids from plants of the genus Ferula

Nazrullaev, S. S.; Saidkhodzhaev, Ashraf I.; Akhmedkhodzhaeva, Kh. S.; Сыров, В. Н.; Rasulev, Bakhtiyor; Хушбактова, З. А.

doi:10.1007/s10600-008-9143-7

Cited by 15 publications

(12 citation statements)

References 4 publications

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“…These compounds have been found in different Ferula species. The presence of sesqui- and diterpene esters of oxygenated benzoic acids is a characteristic feature of the metabolic profile of the plants of genus Ferula (Apiaceae) [ 14 ]. Several Ferula species grow in Iran, F. gumosa (an endemic to Iran) and F. asafetida being the most widespread [ 15 , 16 ].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis

Trusheva

Todorov

Ninova

et al. 2010

Chemistry Central Journal

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BackgroundPropolis (bee glue) has been used as a remedy since ancient times. Propolis from unexplored regions attracts the attention of scientists in the search for new bioactive molecules.ResultsFrom Iranian propolis from the Isfahan province, five individual components were isolated: the prenylated coumarin suberosin 1, and four terpene esters: tschimgin (bornyl p-hydroxybenzoate) 2, tschimganin (bornyl vanillate) 3, ferutinin (ferutinol p-hydroxybenzoate) 4, and tefernin (ferutinol vanillate) 5. All of them were found for the first time in propolis. Compounds 2 - 5 demonstrated activity against Staphylococcus aureus.ConclusionsThe results of the present study are consistent with the idea that propolis from unexplored regions is a promising source of biologically active compounds.

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Section: Resultsmentioning

confidence: 99%

Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis

Trusheva

Todorov

Ninova

et al. 2010

Chemistry Central Journal

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“…The distance between the oxygen of alcohol hydroxyl group and the functional group in the para ‐position of the benzene ring (the hydroxyl or methoxy group) was very important for estrogenic activity. Nazrullaev et al's [] studied confirmed this conclusion. They isolated daucane esters ( 89–110 ) from the genus F erula [Shikishima et al, ; Lhuillier et al, ; Auzi et al, ] and showed daucane esters with an aromatic substituent to have estrogen activity.…”

Section: Daucane Esters Humulane and Germacrane Compoundsmentioning

confidence: 67%

Recent Advances on Bioactive Constituents in Ferula

Zhou

Fang

Zhang

et al. 2017

Drug Development Research

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Preclinical Research The genus Ferula (Umbelliferea) is widely distributed across Central Asia and the Mediterranean. Some plants of the genus Ferula have been used as sources of pharmaceuticals for centuries. Ferula is a rich source of biologically active compounds, including coumarin derivatives, sesquiterpene-substituted compounds, daucane esters, humulane, and germacrane compounds, aromatic lactones and disulfide compounds. Therefore, utilizing these bioactive constituents with antimicrobial and insecticidal effects not only can provide a new strategy for developing drug and green pesticide, but also protect endangered plant resources. In the present review, research advances on the bioactive constituents of the genus Ferula the plant sources. Drug Dev Res 78 : 321-331, 2017. © 2017 Wiley Periodicals, Inc.

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“…The medicinal part of Ferula akitschkensis is root and oleoresin, which have been used to treat headaches, colds, stomach diseases, and other diseases [ 12 – 14 ]. Ferula akitschkensis can regulate estrogen activity and neutrophils and inhibit methicillin-resistant Staphylococcus aureus .…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Effect and Mechanism of Ferula akitschkensis Volatile Oil on Gastric Cancer

Rong

Sun

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ferula akitschkensis volatile oil (FAVO) has a good inhibitory activity on gastric cancer cell proliferation, but the mechanism of action is not yet clear. In this study, we tested the antigastric cancer efficacy and mechanism of FAVO using both in vivo and in vitro models. The results showed that FAVO effectively inhibited the proliferation, migration, and invasion of human gastric cancer SGC-7901 cells, the formation of small tubules of human umbilical vein endothelial cells as well as zebrafish intersegmental vessel and intestinal vein angiogenesis. In vivo experiments showed that FAVO significantly delayed the growth of SGC-7901 tumor-bearing nude mice and induced higher serum IL-2 and IFN-γ and reduced serum IL-6. Western blot results showed that FAVO reduced the expression of HIF-2α, VEGF, VEGFR2, P-VEGFR2, Akt, and P-Akt in SGC-7901 cells with CoCl2 induced hypoxia. We further clarified the main chemical components of FAVO through GC-MS analysis. In summary, FAVO may inhibit tumor growth and angiogenesis via inhibiting the HIF-2α/VEGF signaling pathway.

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Estrogen activity of terpenoids from plants of the genus Ferula

Cited by 15 publications

References 4 publications

Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis

Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis

Recent Advances on Bioactive Constituents in Ferula

The Inhibitory Effect and Mechanism of Ferula akitschkensis Volatile Oil on Gastric Cancer

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