Estrogen and Progesterone Receptor Signaling and Action

Perrotti, Linda I.

doi:10.1002/9783527697274.ch11

Cited by 3 publications

(3 citation statements)

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“…( 12 ) in a large study on a human population found that prenatal progestin exposure was associated with ASD (see section 1.3). According to Perrotti ( 13 ), ERs and progesterone receptors (PRs) function as ligand-dependent transcription factors and their distinctive transcriptional activities are initiated when they bind to their respective ligands, like other members of the nuclear hormone receptor superfamily. The ER and PR signaling pathways are modulated through epigenetic mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Diethylstilbestrol and autism

et al. 2022

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It is acknowledged that diethylstilbestrol (DES), a synthetic diphenol with powerful estrogenic properties, causes structural anomalies of the reproductive tract and increases the risk of cancer and genital malformations in children and grandchildren of mothers treated during pregnancy. Conversely, data on DES effects on neurodevelopment and psychiatric disorders in in-utero exposed children and their descendants are rare, especially concerning Autism Spectrum Disorders (ASD). Recent studies presented in this review strengthen the hypothesis that in-utero exposure to DES and also other synthetic estrogens and progestogens, which all are endocrine disruptors, contributes to the pathogenesis of psychiatric disorders, especially ASD. A large epidemiological study in the USA in 2010 reported severe depression in in-utero exposed children (n=1,612), and a French cohort study (n=1,002 in-utero DES exposed children) in 2016 found mainly bipolar disorders, schizophrenia, major depression, suicide attempts, and suicide. Few publications described ASD in in-utero exposed children, mainly a Danish cohort study and a large Chinese epidemiological study. Molecular studies on endocrine disruptors demonstrated the transgenerational induction of diseases and DES epigenetic impact (DNA methylation changes) at two genes implicated in neurodevelopment (ZFP57 and ADAM TS9). We recently described in an informative family, somatic and psychiatric disorders in four generations, particularly ASD in boys of the third and fourth generation. These data show that the principle of precaution must be retained for the protection of future generations: women (pregnant or not) should be extremely vigilant about synthetic hormones.

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Section: Introductionmentioning

confidence: 99%

Diethylstilbestrol and autism

et al. 2022

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“…ER has classically been considered a nuclear hormone receptor [24,25], with its activation leading to engagement of transcriptional machinery and alterations in gene expression.…”

Section: Introductionmentioning

confidence: 99%

“…ERα has classically been considered a nuclear hormone receptor [24,25], with its activation leading to engagement of transcriptional machinery and alterations in gene expression. However, another type of estrogen receptor activity has been described as well; Arnal and colleagues [26] made the distinction between transcriptional activities and rapid, non-genomic, membrane-initiated steroid signals (“MISS”), and we adopt this terminology here.…”

Section: Introductionmentioning

confidence: 99%

Estradiol enhances ethanol stimulation of ventral tegmental area dopamine neuron firing without limiting ethanol inhibition onto those neurons

Lambeth

Lasek

Mangieri

2020

Preprint

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Females can progress to alcohol and other substance use disorders more quickly than males. The ovarian hormone 17β-estradiol (E2) contributes to sex differences observed in drug use and abuse and may be a principal driver of these differences. However, it is not entirely clear how E2 acts to affect processing of ethanol reward, and several brain regions and mechanisms are implicated. We sought to clarify the role of E2 in modulating the response of ventral tegmental area dopamine neurons to ethanol. To this end, we recorded spontaneous action potentials and inhibitory post synaptic currents from dopaminergic neurons in acute horizontal brain slices from ovariectomized (OVX) dopamine neuron reporter mice (Pitx3-eGFP) treated with either vehicle (VEH) or E2. On the basis of prior work, we hypothesized that E2 administration would cause dopamine cells from OVX+E2 animals to show a more substantial ethanol-induced increase in firing rate compared to control animals. Our data confirmed that ethanol stimulation of the firing rate of dopamine neurons from OVX+E2 mice was greater than that of OVX+VEH animals. Further, we hypothesized that the firing rate increase would be accompanied by a concomitant decrease in ethanol stimulated inhibition onto those same neurons. We found that although ethanol caused the expected increase in GABAA receptor-mediated synaptic inhibition in both groups, there was no difference in this response between OVX+E2 and OVX+VEH animals. Our findings lend additional support for the ability of E2 to enhance ventral tegmental area dopamine neuron responses to ethanol and suggest that this effect is not mediated by an E2-elicited suppression of synaptic inhibition.

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Expression profile of sex steroid hormone estrogen receptors (ERs) in the development of juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ Epinephelus polyphekadion ♂)

Amenyogbe¹,

Chen²,

Wang³

et al. 2020

Afr. J. Agric. Res.

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Recognized for its traditional roles, estrogen is ever-present in all vertebrates, regulates reproduction by binding and activating estrogen receptors (ERs), and also controls several functions of vertebrates, including reproductive immune, and central nervous systems. In order to access any other possible functions of the estrogen receptors in the development of the juvenile Hybrid grouper (Epinephelus fuscoguttatus ♀× Epinephelu polyphekadion ♂), full-length of ERs cDNA sequences were isolated and analyses were found to be 2391 bp for hgERα, 2626 bp for gERb1 and 2339 bp for hgERb2, respectively. The results of amino acid and phylogenetic analysis revealed that each hgER was grouped in consistent taxonomic groups of perciformes and demonstrated great evolutional conservation in functional domains. Real-time PCR examination discovered that the receptors expressed in all tissues examined, though, at a different level, the ERα mRNA level expressed higher than ERβ1, and ERβ2 in tissues examined. The ERα mRNA level of expression was found to be highest in the tissue of the heart, followed by muscle, and liver. The ERβ1 mRNA level was greatest in heart tissue, trailed by liver and muscle and ERβ2 was highest in the heart trailed by stomach and liver. The minimal expression was recorded in the kidney, the gill, and the brain for ERα, ERβ1, and ERβ2 respectively. These results put forward that steroid hormone estrogen receptors might be playing a significant part in the controlling of social behavior complexity, plasticity behavior, and the assessment of a gratifying inducement in Hybrid grouper.

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Estrogen and Progesterone Receptor Signaling and Action

Cited by 3 publications

References 156 publications

Diethylstilbestrol and autism

Diethylstilbestrol and autism

Estradiol enhances ethanol stimulation of ventral tegmental area dopamine neuron firing without limiting ethanol inhibition onto those neurons

Expression profile of sex steroid hormone estrogen receptors (ERs) in the development of juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ Epinephelus polyphekadion ♂)

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