Estrogen Carcinogenesis in Hamster Tissues: A Critical Review*

Li, Jonathan J.; Li, Sara Antonia

doi:10.1210/edrv-11-4-524

Cited by 208 publications

(216 citation statements)

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“…Both oestrogen and progesterone receptors are present in normal and malignant renal cells (Ronchi et al, 1984). High doses of potent oestrogens have been shown to induce renal cell tumours in laboratory rodents (Li and Li, 1990). The proliferative effect of oestrogen on kidney tissue seen experimentally may be mediated through the up-regulation of IGF-I receptors (Chen et al, 1996).…”

Section: Epidemiologymentioning

confidence: 99%

“…Experimental findings of oestrogen-induced renal cell carcinogenesis in animals (Li and Li, 1990) have prompted an interest in the possible influence of hormonal factors in humans. Weak positive associations have been reported for use of oral contraceptives (McLaughlin et al, 1992) and replacement oestrogens in some (Asal et al, 1988;McLaughlin et al, 1992), but not all studies (McLaughlin et al, 1984;Adami et al, 1998).…”

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confidence: 99%

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Pregnancy and risk of renal cell cancer: a population-based study in Sweden

et al. 2002

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Epidemiological findings indicate that hormonal influences may play a role in the etiology of renal cell cancer (RCC). The possible effect of childbearing remains enigmatic; while some investigators have reported a positive association between number of births and renal cell cancer risk, others have not. A case -control study, nested within a nation-wide Fertility Register covering Swedish women born 1925 and later, was undertaken to explore possible associations between parity and age at first birth and the risk of renal cell cancer. Among these women a total of 1465 cases of RCC were identified in the Swedish Cancer Register between 1958 and 1992 and information on the number of live childbirths and age at each birth was obtained by linkage to the Fertility Database. For each case, five age-matched controls were randomly selected from the same register. Compared to nulliparous women, ever-parous women were at a 40% increased risk of RCC (Odds Ratio [OR]=1.42; 95% CI 1.19-1.69). The corresponding OR for women of high parity (five or more live births) was 1.91 (95% CI 1.40 -2.62). After controlling for age at first birth among parous women, each additional birth was associated with a 15% increase in risk (OR=1.15; 95% CI 1.08 -1.22). The observed positive association between parity and renal cell cancer risk is unlikely to be fully explained by uncontrolled confounding, but warrants further evaluation in large studies, with allowance for body mass index.

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Section: Epidemiologymentioning

confidence: 99%

mentioning

confidence: 99%

Pregnancy and risk of renal cell cancer: a population-based study in Sweden

et al. 2002

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“…For instance, several studies have demonstrated that metabolism of estrogens in estrogen target tissues is responsible for estrogen-induced tumor development and cellular transformation [15,16]. This process can occur when oxidation of the native estrogens, estrone, E 1 , or E 2 , by cytochrome P450 enzymes generates two classes of catecholestrogens, the 2-and 4-hydroxylated CEs.…”

Section: Introductionmentioning

confidence: 99%

Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues

2008

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UGT1A10 was recently identified as the major isoform that conjugates estrogens. In this study, realtime PCR revealed high levels of UGT1A10 and UGT2B7 in human breast tissues. The expression of UGT1A10 in breast was a novel finding. UGT1A10 and UGT2B7 mRNAs were differentially expressed among normal and malignant specimens. Their overall expression was significantly decreased in breast carcinomas as compared to normal breast specimens (UGT1A10: 68 ± 26 vs. 252 ± 86, respectively; p < 0.05) and (UGT2B7: 1.4 ± 0.7 vs. 12 ± 4, respectively; p < 0.05). Interestingly, in African American women, UGT1A10 expression was significantly decreased in breast carcinomas in comparison to normals (57 ± 35 vs. 397 ± 152, respectively; p < 0.05). Among Caucasian women, UGT2B7 was significantly decreased in breast carcinomas in comparison to normals (1.1 ± 0.5 vs. 13.5 ± 6, respectively; p < 0.05). Glucuronidation of 4-OHE 1 was significantly reduced in breast carcinomas compared to normals (30 ± 15 vs. 106 ± 31, respectively; p < 0.05). Differential downregulation of UGT1A10 and UGT2B7 mRNA, protein, and activity in breast carcinomas compared to the adjacent normal breast specimens from the same donor were also found. These data illustrate the novel finding of UGT1A10 in human breast and confirm the expression of UGT2B7. Significant individual variation and down-regulation of expression in breast carcinomas of both isoforms was also demonstrated. These findings provide evidence that decreased UGT expression and activity could result in the promotion of carcinogenesis.

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“…One such mechanism may involve quercetin's ability to interfere with estrogen metabolism and the production of estrogen metabolites by altering the mRNA and protein levels of the key estrogen metabolizing enzymes Cyp1A1 and Cyp1B1 [5,6]. Cyp1A1 metabolizes E 2 to generate 2-OHE 2 , a relatively nongenotoxic metabolite, while Cyp1B1 metabolizes E 2 to produce 4-OHE 2 , a highly genotoxic and carcinogenic metabolite [3,5,6,11,12,15,16,[19][20][21][22]. Although quercetin increases the expression of both Cyp1A1 and Cyp1B1, it increases Cyp1A1 to a higher level compared to Cyp1B1.…”

Section: Discussionmentioning

confidence: 99%

“…2-MeOE 2 has antiproliferative and antiangiogenic activities which have been demonstrated both in vitro and in vivo [17,18]. In contrast, 4-OHE 2 induces DNA single strand breaks and oxidative damage [19,20]. Tumorigenic estrogen metabolites such as 4-OHE 2 undergo redox cycling to form electrophilic quinones which readily react with DNA to produce depurinating adducts [6,11,12,21].…”

Section: Introductionmentioning

confidence: 99%

Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin

Mense

Chhabra

Bhat

2008

The Journal of Steroid Biochemistry and Molecular Biology

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Estrogen metabolism is suggested to play an important role in estrogen-induced breast carcinogenesis. Epidemiologic studies suggest that diets rich in phytoestrogens are associated with a reduced risk of breast cancer. Phytoestrogens are biologically-active plant compounds that structurally mimic 17β-estradiol (E 2 ). We hypothesize that phytoestrogens, may provide protection against breast carcinogenesis by altering the expression of estrogen-metabolizing enzymes cytochrome P450 1A1 (Cyp1A1) and 1B1 (Cyp1B1). Cyp1A1 and Cyp1B1 are responsible for the metabolism of E 2 to generate 2-hydroxyestradiol (2-OHE 2 ) and 4-hydroxyestradiol (4-OHE 2 ), respectively. Studies suggest that 2-OHE 2 and 2-methoxyestradiol may protect against breast carcinogenesis, while 4-OHE 2 is carcinogenic in rodent models. Thus, agents that increase the metabolism of E 2 by Cyp1A1 to produce 2-OHE 2 may have chemoprotective properties. The human immortalized non-neoplastic breast cell line MCF10F was treated with quercetin at 10 and 50 µM concentrations for time-points ranging from 3 to 48 hours. Total RNA and protein were isolated. Real-time PCR was used to measure the expression of Cyp1A1 and Cyp1B1 mRNA. Quercetin treatment produced differential regulation of Cyp1A1 and Cyp1B1 mRNA expression in a time-and dose-dependent manner. Treatment with 10 and 50 µM doses of quercetin produced 6-and 11-times greater inductions of Cyp1A1 mRNA over Cyp1B1 mRNA, respectively. Furthermore, quercetin dramatically increased Cyp1A1 protein levels and only slightly increased Cyp1B1 protein levels in MCF10F cells. Thus, our data suggest that phytoestrogens may provide protection against breast cancer by modulating expression of estrogen-metabolizing genes such that production of the highly carcinogenic estrogen metabolite 4-OHE 2 by Cyp1B1 is reduced and the production of the less genotoxic 2-OHE 2 by Cyp1A1 is increased.

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Estrogen Carcinogenesis in Hamster Tissues: A Critical Review*

Cited by 208 publications

References 0 publications

Pregnancy and risk of renal cell cancer: a population-based study in Sweden

Pregnancy and risk of renal cell cancer: a population-based study in Sweden

Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues

Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin

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