Estrogen deficiency during puberty affects the expression of microRNA30a and microRNA503 in the mandibular condyle

Bergamo, Ana Zilda Nazar; Madalena, Isabela Ribeiro; Omori, Marjorie Ayumi; Ramazzotto, Lucas Alexandre; Nelson‐Filho, Paulo; Baratto‐Filho, Flares; Proff, Peter; Kirschneck, Christian; Küchler, Érika Calvano

doi:10.1016/j.aanat.2021.151865

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…80% to 90% of serum levels of vitamin D are synthesized endogenously under UVB irradiation, the remainder, 10% to 20%, come from the diet, the main dietary sources being cholecalciferol (D 3 ) and ergosterol (D 2 ). Estrogen deficiency and vitamin D deficiency share several adverse health outcomes, including bone resorption itself, mood disorders, increased risk of cardiovascular disease and cancers [24][25][26][27][28] affect growth and development [2][3][4][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Estrogen deficiency influences SEC23A gene expression in the odontogenic region of incisors – a murine model study

NASCIMENTO,

SILVEIRA,

PAULA

et al. 2024

Braz. Dent. Sci.

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Recent scientific evidence suggests a close relationship between estrogen deficiency and vitamin D-related genes. Estrogen and vitamin D were involved with alterations in odontogenesis and tooth eruption process. Objective: The aim of the present study was to evaluate the influence of estrogen deficiency on the expression of genes related to the activation and degradation of vitamin D in the odontogenic region of incisors in a murine model. Material and Methods: This is an experimental clinical study that used female Wistar Hannover rats. The animals were randomly divided into two groups according to the intervention received: Hypoestrogenism Group -animals submitted to estrogen deficiency by ovariectomy surgery and Control Group -animals submitted to sham surgery. Surgical intervention was performed in the prepubertal period; the animals were followed throughout the pubertal period. After euthanasia, the hemimandibles were removed to evaluate the mRNA expression of the vitamin D-related genes AMDHD1, CYP24A1, NADSYN1 and SEC23A in the odontogenic region of incisors through real time PCR. Student's t test was used to compare means. Kruskal-Wallis test and Dunn's posttest were also used. The level of significance was 5%. Results: SEC23A was overexpressed in the estrogen deficiency condition in the odontogenic region (p=0.021). Conclusion: Estrogen deficiency may influence the expression of the SEC23A gene involved in the activation and degradation of vitamin D in the odontogenic region of incisors in a murine model.

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Section: Discussionmentioning

confidence: 99%

Estrogen deficiency influences SEC23A gene expression in the odontogenic region of incisors – a murine model study

NASCIMENTO,

SILVEIRA,

PAULA

et al. 2024

Braz. Dent. Sci.

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MiR-30 Family: A Novel Avenue for Treating Bone and Joint Diseases?

Huang¹,

Li²,

Zhu³

et al. 2023

Int. J. Med. Sci.

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Bone and joint diseases are a group of clinically heterogeneous diseases characterized by various bone strength disorders, bone structural defects and bone mass abnormalities. Common bone diseases include osteoporosis, skeletal dysplasia, and osteosarcoma, and common joint diseases include osteoarthritis, rheumatoid arthritis, and degenerative disc disease. all of them lead to high medical costs. The miR-30 family consists of a total of 5 members: miR-30a, miR-30b, miR-30c, miR-30d and miR-30e. Accumulating evidence has indicated that the miR-30 family may be involved in the occurrence and development of bone and joint diseases. For example, miR-30a is highly expressed in blood samples of osteoporosis patients, miR-30a/b increases in cartilage tissue of osteoarthritis patients, and lower expression of miR-30c is associated with higher malignance and shorter survival time of osteosarcoma. Mechanistically, by targeting crucial transcription factors (RUNX2, SOX9, beclin-1, etc.), the miR-30 family regulates some critical pathways of bone homeostasis (Wnt/β-Catenin, mTOR, PI3K/AKT, etc.). In view of the distinct actions of the miR-30 family on bone metabolism, we hypothesize that the miR-30 family may be a new remedy for the clinical treatment and prevention of some bone and joint diseases.

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Estrogen deficiency during puberty affects the expression of microRNA30a and microRNA503 in the mandibular condyle

Cited by 2 publications

References 24 publications

Estrogen deficiency influences SEC23A gene expression in the odontogenic region of incisors – a murine model study

Estrogen deficiency influences SEC23A gene expression in the odontogenic region of incisors – a murine model study

MiR-30 Family: A Novel Avenue for Treating Bone and Joint Diseases?

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