Estrogen Improves Performance of Reinforced T-Maze Alternation and Prevents the Amnestic Effects of Scopolamine Administered Systemically or Intrahippocampally

Fader, Aric J.; Hendricson, Adam W.; Dohanich, Gary P.

doi:10.1006/nlme.1998.3820

Cited by 166 publications

(91 citation statements)

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“…For instance, cyclic estrogen replacement has been shown to significantly improve cognitive function in ovariectomized female monkeys [217]. Furthermore, estrogen replacement has been shown to improve the performance of ovariectomized rats in memory tasks such as radial mazes and water mazes [218][219][220][221][222][223][224][225], as well as in the operant alternation task [226,227] and the active avoidance task [228]. A number of studies have also provided evidence that estrogen can enhance working memory in ovariectomized animals [229][230][231][232].…”

Section: Estrogen and Memorymentioning

confidence: 99%

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

et al. 2007

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Estrogen is an important hormone signal that regulates multiple tissues and functions in the body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum. Sex differences in the risk, onset and severity of neurodegenerative disease such as Alzheimer's disease, Parkinson's disease and stroke are well known, and the potential role of estrogen as a neuroprotective factor is discussed in this context. The review assimilates a complex literature that spans research in humans, non-human primates and rodent animal models and attempts to contrast and compare the findings across species where possible. Current controversies regarding the WHI (Women's Health Initiative) study, its ramifications, concerns and the new studies needed to address these concerns are also addressed. Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators. Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field.

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Section: Estrogen and Memorymentioning

confidence: 99%

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

et al. 2007

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“…Some studies find evidence for decreased spatial abilities (i.e., spatial learning and spatial recognition memory) in high-estrogen phases during the cycle (e.g., Galea and Kavaliers, 1995;Lacreuse et al, 2001). Other studies revealed that NeuroImage 118 (2015) [154][155][156][157][158][159][160][161][162] estrogen administration in ovariectomized rats results in better spatial performance (i.e., spatial working memory; Fader et al, 1998;O'Neal et al, 1996). Lastly, some researchers report stable spatial-memory performance across the estrous cycle (Stackman et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal volume and functional connectivity changes during the female menstrual cycle

et al. 2015

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Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were processed by means of whole-brain voxel-based morphometry and FreeSurfer. With either method, bilateral increases in hippocampal volume were found in the late follicular phase relative to the early follicular phase. The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. In addition, we observed higher functional connectivity between the hippocampi and the bilateral superior parietal lobe in the late follicular phase. We did not find any reliable cycle-related performance variations on the cognitive tasks. The present results show that hormonal fluctuations covary with hippocampal structure and function in the course of the human menstrual cycle.

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“…Many studies have shown that variations in gonadal hormones in female animals -in particular estrogen-lead to structural brain changes, and to changes in behavior (Darnaudéry et al, 2007;DeVoogd & Nottebohm, 1981;Fader, Hendricson, & Dohanich, 1998;Galea & Kavaliers, 1995;Galea et al, 2000;Gibbs, 2000;Korol, 2004;Luine & Frankfurt, 2012;Pawluski, Brummelte, Barha, Crozier, & Galea, 2009;Woolley, 1998;Woolley & McEwen, 1993). Endogenous estrogen fluctuates naturally during the estrous cycle, peaks during pregnancy, and declines at menopause.…”

Section: Introductionmentioning

confidence: 99%

Differences in navigation performance and postpartal striatal volume associated with pregnancy in humans

Lisofsky

Wiener

Condappa

et al. 2016

Neurobiology of Learning and Memory

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a b s t r a c tPregnancy is accompanied by prolonged exposure to high estrogen levels. Animal studies have shown that estrogen influences navigation strategies and, hence, affects navigation performance. High estrogen levels are related to increased use of hippocampal-based allocentric strategies and decreased use of striatal-based egocentric strategies. In humans, associations between hormonal shifts and navigation strategies are less well studied. This study compared 30 peripartal women (mean age 28 years) to an age-matched control group on allocentric versus egocentric navigation performance (measured in the last month of pregnancy) and gray matter volume (measured within two months after delivery). None of the women had a previous pregnancy before study participation. Relative to controls, pregnant women performed less well in the egocentric condition of the navigation task, but not the allocentric condition. A whole-brain group comparison revealed smaller left striatal volume (putamen) in the peripartal women. Across the two groups, left striatal volume was associated with superior egocentric over allocentric performance. Limited by the cross-sectional study design, the findings are a first indication that human pregnancy might be accompanied by structural brain changes in navigation-related neural systems and concomitant changes in navigation strategy.

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Estrogen Improves Performance of Reinforced T-Maze Alternation and Prevents the Amnestic Effects of Scopolamine Administered Systemically or Intrahippocampally

Cited by 166 publications

References 0 publications

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Hippocampal volume and functional connectivity changes during the female menstrual cycle

Differences in navigation performance and postpartal striatal volume associated with pregnancy in humans

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