Estrogen Increases Angiotensin II-Induced c-Fos Expression in the Vasopressinergic Neurons of the Paraventricular Nucleus in the Female Rat

Kisley, Lori R.; Sakai, Randall R.; Flanagan‐Cato, Loretta M.; Fluharty, Steven J.

doi:10.1159/000054599

Cited by 26 publications

(17 citation statements)

References 50 publications

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“…Further, estrogen treatment influences the electrical activity of presumptive oxytocinergic cells in PVN (Akaishi and Sakuma, 1985). Vasopressin-producing neurons are also hormonesensitive, their c-fos reactivity heightened by estrogen pretreatment (Kisley et al, 2000). These various hormone actions play into the thinking and literature covered in the next section.…”

Section: Descending Influences From Paraventricular Nucleus Of the Hymentioning

confidence: 99%

Generalized arousal of mammalian central nervous system

Pfaff

Westberg

Kow

2005

J of Comparative Neurology

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A fundamental capacity of the mammalian CNS is becoming amenable to study with the techniques of functional genomics. Emphasized in this review are ascending connections from the medullary reticular formation and descending connections from the paraventricular nucleus of the hypothalamus. In particular, sex hormone effects on neurons allow us to relate generalized arousal to a specific form of arousal which is required for reproductive behaviors.

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Section: Descending Influences From Paraventricular Nucleus Of the Hymentioning

confidence: 99%

Generalized arousal of mammalian central nervous system

Pfaff

Westberg

Kow

2005

J of Comparative Neurology

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“…This is consistent with the finding that acute s.c. E2 increases i.c.v. AngII-induced Fos expression in PVN vasopressin neurons of OVX rats (Kisley et al, 2000). Accordingly, the data from these studies suggests opposite effects of estrogens on fluid intake and the vasopressin system.…”

Section: Estrogen-peptide Interactionsmentioning

confidence: 99%

Control of fluid intake by estrogens in the female rat: role of the hypothalamus

Santollo

Daniels

2015

Front. Syst. Neurosci.

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Body fluid homeostasis is maintained by a complex network of central and peripheral systems that regulate blood pressure, fluid and electrolyte excretion, and fluid intake. The behavioral components, which include well regulated water and saline intake, are influenced by a number of hormones and neuropeptides. Since the early 1970s, it has been known that the ovarian estrogens play an important role in regulating fluid intake in females by decreasing water and saline intake under a variety of hypovolemic conditions. Behavioral, electrophysiological, gene and protein expression studies have identified nuclei in the hypothalamus, along with nearby forebrain structures such as the subfornical organ (SFO), as sites of action involved in mediating these effects of estrogens and, importantly, all of these brain areas are rich with estrogen receptors (ERs). This review will discuss the multiple ER subtypes, found both in the cell nucleus and associated with the plasma membrane, that provide diversity in the mechanism through which estrogens can induce behavioral changes in fluid intake. We then focus on the relevant brain structures, hypothesized circuits, and various peptides, such as angiotensin, oxytocin, and vasopressin, implicated in the anti-dipsogenic and anti-natriorexigenic actions of the estrogens.

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“…This response is likely modulated by estrogen because it changes the number of Fos-labeled cells in these nuclei observed in response to a variety of stimuli (27,31). Estrogen also attenuates hypotension and the number of Fos-positive cells in the area postrema and lateral parabrachial nucleus, areas closely related to these neuroendocrine responses (32).…”

Section: Table 1 Number Of Total Fos In Sfo and Total Fos And Percenmentioning

confidence: 99%

Estradiol potentiates hypothalamic vasopressin and oxytocin neuron activation and hormonal secretion induced by hypovolemic shock

Mecawi

Vilhena‐Franco

Araujo

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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-Estrogen receptors are located in important brain areas that integrate cardiovascular and hydroelectrolytic responses, including the subfornical organ (SFO) and supraoptic (SON) and paraventricular (PVN) nuclei. The aim of this study was to evaluate the influence of estradiol on cardiovascular and neuroendocrine changes induced by hemorrhagic shock in ovariectomized rats. Female Wistar rats (220 -280 g) were ovariectomized and treated for 7 days with vehicle or estradiol cypionate (EC, 10 or 40 g/kg, sc). On the 8th day, animals were subjected to hemorrhage (1.5 ml/100 g for 1 min). Hemorrhage induced acute hypotension and bradycardia in the ovariectomized-oil group, but EC treatment inhibited these responses. We observed increases in plasma angiotensin II concentrations and decreases in plasma atrial natriuretic peptide levels after hemorrhage; EC treatment produced no effects on these responses. There were also increases in plasma vasopressin (AVP), oxytocin (OT), and prolactin levels after the induction of hemorrhage in all groups, and these responses were potentiated by EC administration. SFO neurons and parvocellular and magnocellular AVP and OT neurons in the PVN and SON were activated by hemorrhagic shock. EC treatment enhanced the activation of SFO neurons and AVP and OT magnocellular neurons in the PVN and SON and AVP neurons in the medial parvocellular region of the PVN. These results suggest that estradiol modulates the cardiovascular responses induced by hemorrhage, and this effect is likely mediated by an enhancement of AVP and OT neuron activity in the SON and PVN.hemorrhage; female rats; supraoptic nuclei; paraventricular nuclei; arterial pressure; heart rate THE PRECISE REGULATION OF body fluids is essential for the metabolic function of virtually all cells in the body. A variety of mechanisms are activated to maintain plasma osmolality and blood volume within a very narrow range of values (3). For example, hypovolemia and/or hypotension induce vasopressin (AVP) and oxytocin (OT) release from the magnocellular neurons of the supraoptic (SON) and paraventricular (PVN) nuclei in the hypothalamus (3, 56). It is estimated that a decrease of 10 -20% in total blood volume induces the release of AVP in several species. This neurosecretory response is modulated by peripheral baroreceptors in the aortic arch and carotid sinus, cardiopulmonary volume receptors, and angiotensin II (ANG II) (50, 65).The precise role of estrogen in maintaining body fluid homeostasis is not yet fully understood (16). Our group has previously reported that ANG II type 1 (AT 1 ) receptors are involved in the regulation of water and hypertonic saline intake in ovariectomized (OVX) rats during the nocturnal period (37, 38). In addition, several reports have suggested that estrogen has modulatory effects on cardiovascular function, as evidenced by the cardiovascular changes observed in postmenopausal women, OVX rats, and, possibly, females of other species during senescence (12, 46). These effects occur by estrogen's action on the...

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Estrogen Increases Angiotensin II-Induced c-Fos Expression in the Vasopressinergic Neurons of the Paraventricular Nucleus in the Female Rat

Cited by 26 publications

References 50 publications

Generalized arousal of mammalian central nervous system

Generalized arousal of mammalian central nervous system

Control of fluid intake by estrogens in the female rat: role of the hypothalamus

Estradiol potentiates hypothalamic vasopressin and oxytocin neuron activation and hormonal secretion induced by hypovolemic shock

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