2015
DOI: 10.3389/fnsys.2015.00025
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Control of fluid intake by estrogens in the female rat: role of the hypothalamus

Abstract: Body fluid homeostasis is maintained by a complex network of central and peripheral systems that regulate blood pressure, fluid and electrolyte excretion, and fluid intake. The behavioral components, which include well regulated water and saline intake, are influenced by a number of hormones and neuropeptides. Since the early 1970s, it has been known that the ovarian estrogens play an important role in regulating fluid intake in females by decreasing water and saline intake under a variety of hypovolemic condi… Show more

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Cited by 32 publications
(29 citation statements)
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References 113 publications
(175 reference statements)
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“…Future studies are needed, however, to determine if sex differences in saline preference affect drinking patterns, or if sex differences in drinking pattern lead to the observed differences in saline preference. Nevertheless, the present studies complement previous work showing sex differences in fluid intake after a number of dipsogenic/natriorexigenic stimuli (Santollo and Daniels, 2015b), by providing the first report, to our knowledge, of sex differences in licking microstructure.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…Future studies are needed, however, to determine if sex differences in saline preference affect drinking patterns, or if sex differences in drinking pattern lead to the observed differences in saline preference. Nevertheless, the present studies complement previous work showing sex differences in fluid intake after a number of dipsogenic/natriorexigenic stimuli (Santollo and Daniels, 2015b), by providing the first report, to our knowledge, of sex differences in licking microstructure.…”
Section: Discussionsupporting
confidence: 87%
“…Finally, others have reported no sex difference in fluid intake after AngII treatment (Sun et al, 1996). The reason for the apparent discrepancy is not clear and the lack of an effect in some studies is surprising given the well documented effects estrogens have on inhibiting AngII-stimulated fluid intake (Curtis, 2009; Krause et al, 2003; Santollo and Daniels, 2015a, b; Santollo et al, 2016). Because females have higher levels of circulating estrogens than males, and estrogens tonically inhibit fluid intake (Jarrar et al, 2000; Overpeck et al, 1978; Tarttelin and Gorski, 1971), it is reasonable to predict that AngII-stimulated fluid intake would be greater in males than females, and difficult to reconcile the discrepancy in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…As an initial step toward testing this hypothesis, we evaluated the effect of all mER subtypes in acutely stimulated water intake and then tested the hypothesis that selective activation of GPER-1 is sufficient to decrease water intake. We also extended these studies to investigate the role of GPER-1 on saline intake because salt, in addition to water, is necessary for proper fluid balance, and estrogens exert an inhibitory effect on intake on both saline and water (Santollo and Daniels, 2015). In addition, we tested for delayed and rapid effects on fluid intake after GPER-1 activation to provide clues about the relevant intracellular actions of GPER-1.…”
Section: Introductionmentioning
confidence: 99%
“…It is well established that E 2 inhibits fluid intake in a number of dipsogenic scenarios mediated by Ang II (Krause et al 2003;Curtis, 2009;Santollo & Daniels, 2015b). This is likely to contribute, at least in part, to the reduced dipsogenic response to Ang II in females compared with males, because females have higher circulating concentrations of E 2 (Santollo et al 2017).…”
Section: Effects Of Oestrogen On Ang Ii-stimulated Fluid Intakementioning
confidence: 99%
“…Estradiol decreases water and saline intake stimulated by central and peripheral Ang II (reviewed by Curtis, ; Santollo & Daniels, ,c). Given that females have higher circulating concentrations of E 2 , it is reasonable to predict that they drink less in response to Ang II than males.…”
Section: Introductionmentioning
confidence: 99%