Estrogen-induced cyclin D1 and D3 gene expressions during mouse uterine cell proliferation in vivo: Differential induction mechanism of cyclin D1 and D3

Geum, Dongho; Sun, Woong; Paik, Sang Ki; Leé, Chung Choo; Kim, Kyungjin

doi:10.1002/(sici)1098-2795(199704)46:4<450::aid-mrd2>3.0.co;2-n

Cited by 52 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…decidualization. Indeed, there is evidence that the expression of D-type cyclins and the cyclindependent kinases are regulated by estrogen in the rodent uterus (Altucci et al 1997, Geum et al 1997, Prall et al 1997. The heightened expression of cyclin D3 mRNA in decidualizing stroma could be due to combined effects of estrogen and P 4 in the presence of a deciduogenic stimulus.…”

Section: Discussionmentioning

confidence: 99%

Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy

Das

Lim²,

Paria³

et al. 1999

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

In the mouse, the attachment reaction between the blastocyst trophectoderm and the receptive uterine luminal epithelium occurs at 2200-2300 h on day 4 of pregnancy and is rapidly followed by transformation of stromal cells into decidual cells (decidual cell reaction). This process can also be induced experimentally (deciduoma) by intraluminal oil infusion in the uterus on day 4 of pseudopregnancy. The decidual cell reaction is associated with up-and down-regulation of many genes in a cell-specific manner. Using mRNA differential display, we identified cyclin D3 as one of the genes that is upregulated in the uterus at the sites of blastocyst apposition during the attachment reaction. The levels of expression were low in the morning of days 1-4 as determined by Northern hybridization. In situ hybridization analysis showed that on days 1 and 2, signals were primarily localized in uterine epithelial cells, while signals were detected in both the stromal and epithelial cells on days 3 and 4. In contrast, with the initiation and progression of decidualization on days 5, 6 and 7, the levels of cyclin D3 mRNA were remarkably upregulated in stromal cells both at the mesometrial and the antimesometrial poles. However, on day 8, signals were primarily localized in stromal cells at the mesometrial decidual bed. Implanting blastocysts on these days also expressed cyclin D3 mRNA. In the progesterone-treated delayed implanting mice, the uterine levels of cyclin D3 mRNA were modest at the sites of blastocyst apposition, but were upregulated with the onset of implantation by estradiol-17 . However, the decidual expression of cyclin D3 mRNA was not dependent on the presence of blastocysts, since increased expression also occurred in experimentally induced deciduoma in the absence of blastocysts. The importance of cyclin D3 in decidualization was further examined in Hoxa-10-deficient mice which show defective decidualization. The expression of cyclin D3 mRNA in Hoxa-10( / ) uteri on day 5 was severely compromised after application of a deciduogenic stimulus on day 4 of pseudopregnancy. Collectively, the results suggest that cyclin D3 could be important for the process of decidualization.

show abstract

Section: Discussionmentioning

confidence: 99%

Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy

Das

Lim²,

Paria³

et al. 1999

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

show abstract

“…There is evidence that cell cycle regulators play important roles in the uterus during the hormonal stimulation (Geum et al 1997, Prall et al 1997, Tong & Pollard 1999 and reproductive cycle (Shiozawa et al 1996(Shiozawa et al , 1998. In humans, the expression of phase-specific cyclins (cyclins D1, E, A, and B1) and CDKs (CDK4, CDK2, and CDC2A) is known to be induced in uterine epithelial and stromal cells during the proliferative phase.…”

Section: Regulation By Ovarian Steroid Hormonesmentioning

confidence: 94%

“…By contrast, during the secretory phase or after P 4 administration, the expression of CDKN1B is strongly induced in the endometrial glands and stromal basalis, which is coincident with their P 4 -dependent growth suppression (Shiozawa et al 1996(Shiozawa et al , 1998. In the case of rodents, uterine expression of cyclins D1 and E and CDK4 is primarily regulated by estrogen in association with uterine epithelial cell proliferation (Geum et al 1997, Prall et al 1997, Tong & Pollard 1999. By contrast, P 4 -dependent inhibition of uterine epithelial cell proliferation appears to be mediated by the decrease in CDK4 activity, presumably through a depression of its expression, as well as by inhibition of the kinase activity through its concomitant association with CDKN1B (Musgrove et al 1998, Tong & Pollard 1999.…”

Section: Regulation By Ovarian Steroid Hormonesmentioning

confidence: 99%

Cell cycle regulatory control for uterine stromal cell decidualization in implantation

2009

View full text Add to dashboard Cite

Uterine stromal cell decidualization is integral to successful embryo implantation, which is a gateway to pregnancy establishment. This process is characterized by stromal cell proliferation and differentiation into decidual cells with polyploidy. The molecular mechanisms that are involved in these events remain poorly understood. The current concept is that locally induced factors with the onset of implantation influence uterine stromal cell proliferation and/or differentiation through modulation of core cell cycle regulators. This review will aim to address the currently available knowledge on interaction between growth factor/homeobox and cell cycle regulatory signaling in the progression of various aspects of decidualization.

show abstract

“…B, ER␣ mRNA of these breast carcinoma cells was analyzed by RT-qPCR using the ABI PRISM 7700 sequence detection system and correlated with FoxM1 and FoxO3a expression. The expression levels of ER␣ protein and mRNA were correlated with the expression levels of FoxO3a and FoxM1 proteins in individual cell lines (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). ϩ indicates positive correlation, and Ϫ denotes no correlation for each cell line.…”

Section: Induction Of Foxm1 Expression In An Mcf-7 Tet-on Systemmentioning

confidence: 99%

The Forkhead Box M1 Protein Regulates the Transcription of the Estrogen Receptor α in Breast Cancer Cells

Madureira

Varshochi

Constantinidou

et al. 2006

Journal of Biological Chemistry

159

121

View full text Add to dashboard Cite

show abstract

Estrogen-induced cyclin D1 and D3 gene expressions during mouse uterine cell proliferation in vivo: Differential induction mechanism of cyclin D1 and D3

Cited by 52 publications

References 37 publications

Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy

Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy

Cell cycle regulatory control for uterine stromal cell decidualization in implantation

The Forkhead Box M1 Protein Regulates the Transcription of the Estrogen Receptor α in Breast Cancer Cells

Contact Info

Product

Resources

About