Estrogen modulation of NMDA-induced seizures in ovariectomized and non-ovariectomized rats

Kalkbrenner, Kristen A; Standley, Cynthia A.

doi:10.1016/s0006-8993(02)04065-9

Cited by 56 publications

(43 citation statements)

References 17 publications

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“…Numerous studies over the last few decades have identified sex and cycle-dependent differences in seizure susceptibility in rodents. These studies have used various methods to induce seizures, including kindling, electroshock, and chemoconvulsant administration Buterbaugh, 1989;Edwards et al, 1999;Finn and Gee, 1994;Hoffman et al, 2003;Hom and Buterbaugh, 1986;Hudson and Buterbaugh, 1991;Kalkbrenner and Standley, 2003;Matejovska et al, 1998;Nicoletti et al, 1985;Pericic and Bujas, 1997;Persinger et al, 1988;Pesce et al, 2000;Schwartz-Giblin et al, 1989;Slamberova and Vathy, 2000;Tan and Tan, 2001;Tominaga et al, 2001;Valente et al, 2002;Velisek et al, 1999;Wahnschaffe and Loscher, 1992;Woolley, 2000). However, these studies have failed to provide a clear picture of the relationship between ovarian hormone levels and seizure susceptibility.…”

Section: Introductionmentioning

confidence: 99%

“…A possible reason for this is that most studies have used ovariectomized rats, treated with a variety of different hormone replacement regimens. These regimens cannot easily be compared because both estrogen and progesterone may have variable effects depending on the dose and duration of treatment (Edwards et al, 1999;Kalkbrenner and Standley, 2003;Schwartz-Giblin et al, 1989;Tominaga et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

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Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine

Scharfman

Goodman

Rigoulot

et al. 2005

Experimental Neurology

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Despite numerous neuroendocrinological studies of seizures, the influence of estrogen and progesterone on seizures and epilepsy remains unclear. This may be due to the fact that previous studies have not systematically compared distinct endocrine conditions and included all relevant controls. The goal of the present study was to conduct such a study using pilocarpine as chemoconvulsant. Thus, age and weight-matched, intact or ovariectomized rats were tested to determine incidence of status epilepticus and to study events leading to status. Intact female rats were sampled at each cycle stage (proestrus, estrus, metestrus, or diestrus 2). Convulsant was administered at the same time of day, 10:00-10:30 a.m. Statistical analysis showed that there was a significantly lower incidence of status on the morning of estrus, but differences were attenuated in older animals. Ovariectomized rats were distinct in their rapid progression to status. These results show that the incidence of status in female rats following pilocarpine injection, and the progression to pilocarpineinduced status, are influenced by reproductive state as well as age. The hormonal milieu present specifically on the morning of estrus appears to decrease susceptibility to pilocarpine-induced status, particularly at young ages. In contrast, the chronic absence of reproductive steroids that characterizes the ovariectomized rat leads to a more rapid progression to status. This dissociation between incidence vs. progression provides new insight into the influence of estrogen and progesterone on seizures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine

Scharfman

Goodman

Rigoulot

et al. 2005

Experimental Neurology

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“…In contrast, there are several studies of chronic estrogen administration in females that show either anticonvulsant or no effect of estrogen on seizures 30–32. In low doses, estradiol can produce neuroprotective effects 33.…”

Section: Pathophysiology Of Catamenial Epilepsymentioning

confidence: 97%

Diagnosis and management of catamenial seizures: a review

Verrotti¹,

D’Egidio²,

Agostinelli³

et al. 2012

IJWH

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Catamenial epilepsy is defined as a pattern of seizures that changes in severity during particular phases of the menstrual cycle, wherein estrogens are proconvulsant, increasing the neuronal excitability; and progesterone is anticonvulsant, enhancing GABA-mediated inhibition. Thus, changes in serum estradiol/progesterone ratio throughout a normal reproductive cycle bring about an increased or decreased risk of seizure occurrence. To date, there are no specific drug treatments for catamenial epilepsy however, non-hormonal and hormonal therapies have been proposed. The aim of this review is to report preclinical and clinical evidences about the relationship between female reproductive steroids and epileptic seizures, and to describe treatment approaches for catamenial epilepsy.

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“…24 In contrary, other studies showed that estrogen may decrease seizures. In ovarectomized female rats, ␤-estradiol can reduce seizues induced by N-methyl-Daspartate (NMDA) 25 or Kainic acid (KA). 24 A decline in seizure frequency was reported in some women with primary generalized seizures around the time of ovulation 26 and in postmenopausal epileptic women utilizing estrogen as replacement hormonal therapy.…”

Section: Hormones and Seizures Estrogenmentioning

confidence: 99%