Estrogen production by fetal and infantile rat ovaries

Jp, Weniger; Zeis, A; Chouraqui, J

doi:10.1051/rnd:19930205

Cited by 34 publications

(29 citation statements)

References 13 publications

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“…The co-expression of both ER subtypes with comparatively intense signals in the foetal ovary suggests their role in the initial stage of ovarian development. The onset of folliculogenesis is concomitant with detection of basal oestrogen levels in the blood, which significantly increases with age (Weniger et al 1993). Thus, the sharp rise of ER mRNA signals in granulosa cells in the first week of the neonatal period, coincident with the onset of folliculogenesis, indicates its involvement in follicular differentiation and function.…”

Section: Discussionmentioning

confidence: 99%

Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization

Mowa

Iwanaga²

2000

Journal of Endocrinology

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This study employed an in situ hybridization technique to compare the cellular expression of oestrogen receptor (ER) subtypes, ER and , in the female reproductive organ of the rat during prenatal and postnatal periods. Diffuse signals of ER and mRNAs were co-expressed in the foetal ovary; they were weak and inconsistent before onset of gonadal differentiation, but increased in intensity with age. ER mRNA signals in the ovary sharply increased in intensity to adult levels by postnatal days 6-7, whereas those of ER mRNA remained unchanged after birth. ER was the sole subtype expressed during the prenatal period from the oviduct to the vagina, being localized mainly to the sub-epithelial stromal cells, and remained predominant thereafter. Signals for ER mRNA in the epithelia were confined to the oviduct during prenatal and early postnatal periods; those in uterine and vaginal epithelia first appeared by postnatal days 4-5 and 6 respectively. Expressions of ER mRNA in the reproductive tract were absent during the prenatal period, and were weakly expressed during the postnatal period. Thus, oestrogen action in the developing ovary may be comediated by both ER and , whereas ER may be the primary mediator in the differentiation and growth of the female reproductive tract.

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Section: Discussionmentioning

confidence: 99%

Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization

Mowa

Iwanaga²

2000

Journal of Endocrinology

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“…Maternal estrogens are largely bound to ␣-fetoprotein. Fetal ovaries are not a source of estradiol (46), although estradiol is made in the fetal testes through the aromatization from testosterone (6). The largest source of estrogen in both sexes is the placenta, although the murine placenta does not participate in gonadal steroid production during the second half of pregnancy (2,14).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the mechanism of Met⁵-enkephalin-induced cardioprotection: role of PI3K/Akt

Cao¹,

Liu²,

Packwood³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

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“…However, it is quite unlikely that ArKO females have been masculinized during perinatal development due to excessive exposure to androgens (since they are not able to aromatize androgenic precursor into an estrogen; Bakker et al, 2004b). First, the fetal and neonatal rodent ovary does not produce sex steroids (Lamprecht et al, 1976;Weniger et al, 1993), making it unlikely that there is an accumulation of androgenic substrate in ArKO females. Second, ArKO females showed very low levels of male-typical sexual behavior in adulthood following treatment with testosterone and estradiol (Bakker et al, 2002a,b).…”

Section: Discussionmentioning

confidence: 99%

Enhanced urinary odor discrimination in female aromatase knockout (ArKO) mice

Wesson

Keller

Douhard

et al. 2006

Hormones and Behavior

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We asked whether odor discrimination abilities are sexually dimorphic in mice and, if so, whether the perinatal actions of estradiol contribute to these sex differences. The ability to discriminate different types of urinary odors was compared in male and female wild-type (WT) subjects and in mice with a homozygous-null mutation of the estrogen synthetic enzyme, aromatase (aromatase knockout; ArKO). Olfactory discrimination was assessed in WT and ArKO male and female mice after they were gonadectomized in adulthood and subsequently treated with estradiol benzoate. A liquid olfactometer was used to assess food-motivated olfactory discrimination capacity. All animals eventually learned to distinguish between urinary odors collected from gonadally intact males and estrous females; however, WT males as well as ArKO mice of both sexes learned this discrimination significantly more rapidly than WT females. Similar group differences were obtained when mice discriminated between urinary odors collected from gonadally intact vs. castrated males or between two non-social odorants, amyl and butyl acetate. When subjects had to discriminate volatile urinary odors from ovariectomized female mice treated with estradiol sequenced with progesterone versus estradiol alone, ArKO females quickly acquired the task whereas WT males and females as well as ArKO males failed to do so. These results demonstrated a strong sex dimorphism in olfactory discrimination ability, with WT males performing better than females. Furthermore, female ArKO mice showed an enhanced ability to discriminate very similar urinary odorants, perhaps due to an increased sensitivity of the main olfactory nervous system to adult estradiol treatment as a result of perinatal estrogen deprivation. © 2005 Elsevier Inc. All rights reserved.Keywords: Estrogens; Sex differences; Olfaction; Odor discrimination; Learning Sex differences have been reported in olfactory sensitivity, with females being better able than males to detect male-derived odors. For instance, sows are significantly better than boars at using decreasing concentrations of the volatile male pig pheromone, androstenone, as a discriminative stimulus in operant tests for a sucrose reward (Dorries et al., 1995). In addition, using measurements of regional cerebral blood flow with positron emission tomography (Savic et al., 2001), women but not men show a significant activation of the preoptic area and ventromedial nuclei of the hypothalamus when actively smelling androstadienone, an androgenic compound secreted by the axillary glands in much higher concentrations in men than in women (Gower and Ruparelia, 1993). These sex differences in olfactory sensitivity are not only restricted to the detection of opposite sex odors, but also involve same-sex odors. For instance, using habituation/dishabituation tests to determine odor attraction thresholds, female mice respond more reliably than male mice to low concentrations of volatile urinary odors from either sex (Baum and Keverne, 2002;Pierman et al., 20...

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Estrogen production by fetal and infantile rat ovaries

Cited by 34 publications

References 13 publications

Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization

Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization

Sex differences in the mechanism of Met⁵-enkephalin-induced cardioprotection: role of PI3K/Akt

Enhanced urinary odor discrimination in female aromatase knockout (ArKO) mice

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Estrogen production by fetal and infantile rat ovaries

Cited by 34 publications

References 13 publications

Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization

Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization

Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt

Enhanced urinary odor discrimination in female aromatase knockout (ArKO) mice

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Sex differences in the mechanism of Met⁵-enkephalin-induced cardioprotection: role of PI3K/Akt