2023
DOI: 10.3390/cells12060895
|View full text |Cite
|
Sign up to set email alerts
|

Estrogen Receptor Alpha Splice Variants, Post-Translational Modifications, and Their Physiological Functions

Abstract: The importance of estrogenic signaling for a broad spectrum of biological processes, including reproduction, cancer development, energy metabolism, memory and learning, and so on, has been well documented. Among reported estrogen receptors, estrogen receptor alpha (ERα) has been known to be a major mediator of cellular estrogenic signaling. Accumulating evidence has shown that the regulations of ERα gene transcription, splicing, and expression across the tissues are highly complex. The ERα promoter region is c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 9 publications
(1 citation statement)
references
References 105 publications
0
1
0
Order By: Relevance
“…Several splice variants of full-length ERs have been reported in various healthy tissues and cancers [158,159]. These truncated ERα and ERβ receptor proteins arise from mutations in ESR1 and ESR2 genes but cannot form homodimers or recruit cofactors like full-length ERs [160].…”
Section: Oestrogen Signalling Via Truncated Ers In Colon Cancermentioning
confidence: 99%
“…Several splice variants of full-length ERs have been reported in various healthy tissues and cancers [158,159]. These truncated ERα and ERβ receptor proteins arise from mutations in ESR1 and ESR2 genes but cannot form homodimers or recruit cofactors like full-length ERs [160].…”
Section: Oestrogen Signalling Via Truncated Ers In Colon Cancermentioning
confidence: 99%