Estrogen receptor positive breast cancers and their association with environmental factors

St‐Hilaire, Sophie; Mandal, Rakesh; Commendador, Amy; Mannel, Sylvio; Derryberry, DeWayne R.

doi:10.1186/1476-072x-10-32

Cited by 22 publications

(15 citation statements)

References 21 publications

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“…One study suggested that ER+ case patients had higher DDE concentrations compared to controls 30 and a recent Environmental Protection Agency (EPA) report found that ER+ breast cancer was positively associated with proportion of agricultural land by county of residence. 31 Consistent with this, ever seeing a fogger truck at a residence prior to 1972 was associated with a higher odds of ER+PR+ tumors in the Long Island Breast Cancer Study Project (OR: 1.44; 95% CI: 1.08, 1.93). 9 However two other studies reported no difference in DDT concentration by hormone receptor status 32,33 and one report found varying associations between different organochlorine compounds and hormone receptor status.…”

Section: Discussionmentioning

confidence: 59%

Childhood and Adolescent Pesticide Exposure and Breast Cancer Risk

Niehoff¹,

Nichols²,

White³

et al. 2016

Epidemiology

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Background To date, epidemiological studies have not strongly supported an association between pesticide exposure and breast cancer. However, few previous studies had the ability to assess specific time periods of exposure. Studies that relied on adult serum levels of metabolites of organochlorine pesticides may not accurately reflect exposure during developmental periods. Further, exposure assessment often occurred after diagnosis and key tumor characteristics, such as hormone receptor status, have rarely been available to evaluate tumor-subtype specific associations. We examine the association between pesticide exposure during childhood and adolescence and breast cancer risk in the prospective Sister Study cohort (N=50,844 women) to assess this relation by tumor subtype. Methods During an average 5-year follow-up, 2,134 incident invasive and in situ breast cancer diagnoses were identified. Residential and farm exposure to pesticides were self-reported at study enrollment during standardized interviews. Multivariable hazard ratios (HR) and 95% confidence intervals for breast cancer risk were calculated with Cox proportional hazards regression. Results HRs were near null for the association between childhood/adolescent pesticide exposure and breast cancer risk overall or among ER+/PR+ invasive tumors. However, among women who were ages 0–18 before the ban of DDT in the U.S., exposure to fogger trucks or planes was associated with a HR=1.3 for premenopausal breast cancer (95% CI: 0.92, 1.7). Conclusion These findings do not support an overall association between childhood and adolescent pesticide exposure and breast cancer risk. However, modest increases in breast cancer risk were associated with acute events in a subgroup of young women.

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Section: Discussionmentioning

confidence: 59%

Childhood and Adolescent Pesticide Exposure and Breast Cancer Risk

Niehoff¹,

Nichols²,

White³

et al. 2016

Epidemiology

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show abstract

“…Recent epidemiological literature indicates that risk factors for breast disease may differ according to hormone receptor expression and suggests that breast cancers stratified by hormone receptor status may represent etiologically distinct diseases with different clinical, pathologic, and molecular features . Likewise, the toxicokinetic properties of organochlorines have been hypothesized to be different based on clinical characteristics of the primary carcinoma, yet few studies have investigated these relationships in women with breast cancer and available data are inconsistent and contradictory.…”

Section: Discussionmentioning

confidence: 99%

Organochlorine pesticide residues in human breast tissue and their relationships with clinical and pathological characteristics of breast cancer

Ellsworth

Kostyniak

Chi

et al. 2018

Environmental Toxicology

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Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women with various stages of breast health to determine patterns of bioaccumulation within the breast and to assess relationships with patient clinical characteristics. Three organochlorine residues-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and mirex-assayed by high resolution gas chromatography were abundant in breast tissue. p,p'-DDE (745 ± 1054 ng/g lipid) was the most prevalent residue, comprising 97.5% of the total chemical burden. Mean levels of p,p'-DDE and HCB were significantly correlated (P < .001) with patient age at mastectomy, and levels of p,p'-DDE were correlated (P < .05) with BMI. Pesticide concentrations did not differ significantly by breast quadrant and were not different in the quadrant(s) where the primary tumor was located compared to other cancer-free quadrants. In invasive cancer patients, organochlorine levels differed significantly based on clinical characteristics of the primary carcinoma, including stage, grade, ER status, and HER2 status, indicating that body burden of organochlorines may influence the development of specific subtypes of breast cancer. Potentially carcinogenic organochlorines were present at high levels within the human breast warranting further research to determine the impact of organochlorines in the etiology of breast cancer.

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“…The effect of hormones on mitochondria provides a possible link by which endocrine disrupting chemicals can influence the outcome of breast cancer and other diseases[164]. Of particular interest are estrogens that regulate glycolysis, the TCA cycle and OxPhos in a sex-specific specific manner [165].…”

Section: Host and Environmental Factors Affecting Mitochondrial Mementioning

confidence: 99%

Impaired Mitochondrial Metabolism and Mammary Carcinogenesis

Yadava

Schneider

Jerry

et al. 2012

J Mammary Gland Biol Neoplasia

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Mitochondrial oxidative metabolism plays a key role in meeting energetic demands of cells by oxidative phosphorylation (OxPhos). Here, we have briefly discussed (i) the dynamic relationship that exists among glycolysis, the tricarboxylic acid (TCA) cycle, and OxPhos; (ii) the evidence of impaired OxPhos (i.e. mitochondrial dysfunction) in breast cancer; (iii) the mechanisms by which mitochondrial dysfunction can predispose to cancer; and (iv) the effects of host and environmental factors that can negatively affect mitochondrial function. We propose that impaired OxPhos could increase susceptibility to breast cancer via suppression of the p53 pathway, which plays a critical role in preventing tumorigenesis. OxPhos is sensitive to a large number of factors intrinsic to the host (e.g. inflammation) as well as environmental exposures (e.g. pesticides, herbicides and other compounds). Polymorphisms in over 143 genes can also influence OxPhos system. Therefore, declining mitochondrial oxidative metabolism with age due to host and environmental exposures could be a common mechanism predisposing to cancer.

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Estrogen receptor positive breast cancers and their association with environmental factors

Cited by 22 publications

References 21 publications

Childhood and Adolescent Pesticide Exposure and Breast Cancer Risk

Childhood and Adolescent Pesticide Exposure and Breast Cancer Risk

Organochlorine pesticide residues in human breast tissue and their relationships with clinical and pathological characteristics of breast cancer

Impaired Mitochondrial Metabolism and Mammary Carcinogenesis

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