Estrogen Receptor α Influences Socially Motivated Behaviors

Imwalle, D. Bradley; Scordalakes, Elka M.; Rissman, Emilie F.

doi:10.1006/hbeh.2002.1837

Cited by 87 publications

(68 citation statements)

References 34 publications

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“…Regarding the social recognition, female αERKO and βERKO mice have also been shown to differ in the extent of their attenuation of social memory . In addition, αERKO males displayed reduced aggressive behavior towards other males while βERKO males displayed enhanced inter-male aggressiveness relative to their WTs (Ogawa et al, 1998(Ogawa et al, , 2000Imwalle et al, 2002;Nomura et al, 2002;Rissman et al, 1999;Scordalakes and Rissman, 2003;Dominguez-Salazar et al, 2004). In this regard, it has been suggested that ERβ activation may exert an attenuating effect on male aggression induced by estrogen through ERα-mediated mechanisms (Nomura et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…There is mounting evidence that estrogens and estrogen receptors (ERs) have an important role in determining various aspects of social and sexual behavior in males as well as in females. Mice in which the genes encoding either estrogen receptor α (ERα) or estrogen receptor β (ERβ) had been disrupted (ER-knockout mice (ERKO, αERKO, βERKO)) were impaired in their olfactorymediated social recognition (Imwalle et al, 2002;Choleris et al, 2003Choleris et al, , 2006. In addition, ERα has been associated with the mediation of male aggression and sexual behavior.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Kavaliers

Devidze

Choleris

et al. 2008

Psychoneuroendocrinology

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SummaryMale risk taking and decision making are affected by sex-related cues, with men making poorer and riskier decisions in the presence of females and, or their cues. In non-human species, female cues can also increase male risk taking, reducing their responses to predator threat. As estrogen receptors α and β (ERα and ERβ) are involved in the mediation of social and sexual responses, we investigated their roles in determining the effects of female-associated cues on male risk taking. We examined the effects of brief pre-exposure to the odors of either a novel or familiar estrous female on the avoidance of, and aversive responses to, predator threat (cat odor) in ERα and ERβ wild type (αERWT, βERWT) and gene-deleted (knockout, αERKO, βERKO) male mice. Exposure of αERWT and βERWT males to the odors of a novel, but not a familiar, estrous female mouse resulted in enhanced risk taking with the males displaying reduced avoidance of, and analgesic responses to, cat odor. In contrast, αERKO male mice failed to show any changes in risk taking, while βERKO males, although displaying greater risk taking, did not distinguish between novel and familiar females, displaying similarly reduced avoidance responses to cat odor after exposure to either a novel or familiar female odor. These findings indicate that the gene for ERα is associated with the sexual mechanisms (response to estrous female) and the genes for ERβ and ERα with the social (recognition of novel female) mechanisms underlying the effects of female cues on male risk taking. *Corresponding author. kavalier@uwo.ca (M. Kavaliers).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Kavaliers

Devidze

Choleris

et al. 2008

Psychoneuroendocrinology

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“…During each 1 min interaction, we recorded the amount of time the resident spent sniffing the body, head, or tail of the OVX female. At the end of the eighth introduction, a novel OVX female was introduced and again chemoinvestigation was scored (Imwalle et al, 2002). Last, 3 d after social recognition testing, we studied aggression, using a resident/intruder test paradigm.…”

Section: Methodsmentioning

confidence: 99%

Sex Chromosome Complement and Gonadal Sex Influence Aggressive and Parental Behaviors in Mice

Gatewood¹,

Wills²,

Shetty³

et al. 2006

J. Neurosci.

223

227

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Across human cultures and mammalian species, sex differences can be found in the expression of aggression and parental nurturing behaviors: males are typically more aggressive and less parental than females. These sex differences are primarily attributed to steroid hormone differences during development and/or adulthood, especially the higher levels of androgens experienced by males, which are caused ultimately by the presence of the testis-determining gene Sry on the Y chromosome. The potential for sex differences arising from the different complements of sex-linked genes in male and female cells has received little research attention. To directly test the hypothesis that social behaviors are influenced by differences in sex chromosome complement other than Sry, we used a transgenic mouse model in which gonadal sex and sex chromosome complement are uncoupled. We find that latency to exhibit aggression and one form of parental behavior, pup retrieval, can be influenced by both gonadal sex and sex chromosome complement. For both behaviors, females but not males with XX sex chromosomes differ from XY. We also measured vasopressin immunoreactivity in the lateral septum, which was higher in gonadal males than females, but also differed according to sex chromosome complement. These results imply that a gene(s) on the sex chromosomes (other than Sry) affects sex differences in brain and behavior. Identifying the specific X and/or Y genes involved will increase our understanding of normal and abnormal aggression and parental behavior, including behavioral abnormalities associated with mental illness.

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“…Both ERs are necessary for social recognition in mice (Choleris et al, 2003;Imwalle et al, 2002), with recent indication of differential involvement of the two receptors . This suggests that the two ERs may play a role in social learning too.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Estrogen Receptor Alpha and Beta Specific Agonists on Social Learning of Food Preferences in Female Mice

Clipperton

Spinato

Chernets

et al. 2007

Neuropsychopharmacol

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There is an evolutionary advantage to learning food preferences from conspecifics, as social learning allows an individual to bypass the risks associated with trial and error individual learning. The social transmission of food preferences (STFP) paradigm examines this advantage. Females in the proestrus and diestrus phases of the estrous cycle show a prolonged preference for the demonstrated food relative to estrus and ovariectomized females. Additionally, both estrogen receptor alpha (ERa) and estrogen receptor beta (ERb) knockout mice show impaired social recognition, which suggests that both receptors may be involved in other types of socially dependent learning, including the STFP. The present study investigated the effect of the ERa selective agonist PPT (1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole) and the ERb selective agonist WAY-200070 (7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol) on the STFP. Results showed that ovariectomized (ovx) mice treated with PPT failed to learn the socially acquired preference, while WAY-200070-treated ovx mice showed a two-fold prolonged preference for the food eaten by their demonstrator. The effects of PPT on the socially acquired food preference cannot be explained by effects on the total food intake of the groups or on the type of interaction with the demonstrator mouse. The effects of WAY-200070 may be partially due to effects on Submissive Behavior. The higher WAY-200070 doses produced prolonged preferences similar to those seen previously in intact female mice during the proestrus and diestrus phases. This suggests that the estrous cycle's effects on social learning may be due to the action of ERb on Submissive Behavior, or to ERb countering that of ERa.

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Estrogen Receptor α Influences Socially Motivated Behaviors

Cited by 87 publications

References 34 publications

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Sex Chromosome Complement and Gonadal Sex Influence Aggressive and Parental Behaviors in Mice

Differential Effects of Estrogen Receptor Alpha and Beta Specific Agonists on Social Learning of Food Preferences in Female Mice

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