2008
DOI: 10.1002/ijc.23532
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Estrogen receptor β deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice

Abstract: Clinical evidence suggests that estradiol replacement therapy reduces colon cancer risk in ‘post’menopausal women. In colon epithelial cells, the estrogen receptor β (ERβ) is the predominant ER subtype and is thought to mediate the genomic effect of estrogens. The first aim of this study was to investigate the consequence of ERβ deficiency on intestinal tumorigenesis in the ApcMin/+ mouse model. Furthermore, to explore the biological mechanisms by which estrogens may influence the pathogenesis of colorectal ca… Show more

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Cited by 74 publications
(60 citation statements)
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“…1). In contrast, in the small intestine of the Min mouse, OVX reportedly increases adenomagenesis, perhaps owing to the loss of a suppressive estrogen effect (21,22). However, our analysis of the large dataset of Min mice from the McArdle Laboratory provided only marginally significant evidence for a 1.1-fold increased female susceptibility to adenoma development in the small intestine (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…1). In contrast, in the small intestine of the Min mouse, OVX reportedly increases adenomagenesis, perhaps owing to the loss of a suppressive estrogen effect (21,22). However, our analysis of the large dataset of Min mice from the McArdle Laboratory provided only marginally significant evidence for a 1.1-fold increased female susceptibility to adenoma development in the small intestine (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Other inflammation-related genes that have been examined in the APC min model either show no apparent sex specificity or show a female-specific effect (8,11,12). The male-specific effect in our study is somewhat surprising, but may have important clinical implications.…”
Section: Discussionmentioning
confidence: 51%
“…Interestingly, the inflammation profiles of the colonic and small-intestinal tumors from APC min mice are different, with the colonic tumors demonstrating more infiltrating immune cells and cytokine expression (7). Genetic evidence also suggests qualitative differences between APC min small-intestinal and colonic tumors (8,9). The APC min mouse has sex-specific phenotypes, whereby male APC min mice demonstrate higher multiplicity of colon tumors (10).…”
Section: Introductionmentioning
confidence: 99%
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“…21 Apc MIN/C mice present pathological differences in the small-intestinal and colonic regions 33,34 as well as female and male specific variances. [35][36][37] Thus, FS2s anti-tumor activity was studied in both male and female Apc MIN/C mice.…”
Section: Fibersol-2 Decreases the Number Of Adenomas In The Small Intmentioning
confidence: 99%