Estrogen Receptors in the Human Female Lower Urinary Tract

Iosif, Constantin S.; Batra, Satish; Ek, Åsa; Åstedt, Birger

doi:10.1097/00006254-198205000-00022

Cited by 44 publications

(56 citation statements)

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“…It is well known that estrogen and progesterone receptors have been found throughout the lower urinary tract [16], and many of the tissues involved in female continence have been found to be estrogen-sensitive, such as the urethra and bladder. Because estrogens are also known to have an effect on the synthesis of collagen and the metabolism of collagen in the lower genital tract, the significant difference that we found between pre- and postmenopausal patients is likely related to the loss of estrogen support of urogenital tissues [17].…”

Section: Discussionmentioning

confidence: 99%

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Transobturator Tape Operation Is More Effective in Premenopausal Women than in Postmenopausal Women with Stress Incontinence

et al. 2011

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PurposeMidurethral synthetic slings for female stress urinary incontinence are minimally invasive polypropylene mesh tapes that are inserted under the midurethra with trocars. In the past decade, this new technology has become the most commonly performed procedure for female stress urinary incontinence, replacing the traditional open procedures. However, its effectiveness in pre- and postmenopausal women has not previously been compared.Materials and MethodsWe assessed the clinical outcome of the transobturator tape (TOT) procedure in premenopausal (n=45) and postmenopausal (n=49) women by means of self-report and the Urinary Distress Inventory 6 (UDI-6) questionnaire.ResultsThe mean age of the pre- and postmenopausal women was 44 and 60 years, respectively. Mean parity was 2.4 and 3, respectively. There were no significant differences with respect to mean operation time, duration of hospitalization, or intraoperative and postoperative complications. However, premenopausal women were more satisfied with the operation than were postmenopausal women (p=0.014). Also, UDI-6 scores were significantly better in premenopausal women (p=0.027).ConclusionsThe TOT operation appeared to be more effective in premenopausal women with stress urinary incontinence. However, further studies with larger sample sizes are needed to confirm our results.

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Section: Discussionmentioning

confidence: 99%

“…In fact, estrogen receptors have been found in the urethra and bladder trigone as well as in the round ligaments and levator ani muscles [3,4]. Following those findings, the idea arose of a possible relation between SUI and the causes of decreased estrogen status, such as menopause.…”

Section: Introductionmentioning

confidence: 99%

Transobturator Tape Operation Is More Effective in Premenopausal Women than in Postmenopausal Women with Stress Incontinence

et al. 2011

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“…Estrogen receptors have been shown in biopsy specimens from the bladder trigone, proximal urethra, distal urethra, vagina and vesico-vaginal connective tissue contiguous with the bladder neck. 12, 13,14 While ERs were present in urethral squamous epithelium, they were not present in urothelial tissue of the lower urinary tract. Progesterone receptors are more variable and found mostly in subepithelial tissues.…”

Section: Vaginal Estrogen: Urinary Tract Infections and Lower Urinarymentioning

confidence: 94%

Local Effects of Vaginally Administered Estrogen Therapy

Krause¹,

Wheeler²,

Snyder³

et al. 2009

Journal of Pelvic Medicine and Surgery

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The results of the Women’s Health Initiative (WHI) led to a distinct decline in the routine use of estrogen as preventive therapy for vasomotor symptoms, osteoporosis, and cardiovascular disease in postmenopausal women. Without estrogen replacement, one third of women experience symptoms of atrophic vaginitis including dryness, irritation, itching and or dyspareunia. Local application of estrogen has been shown to relieve these symptoms and improve quality of life for these women. In addition, local estrogen therapy may have a favorable effect on sexuality, urinary tract infections, vaginal surgery, and incontinence. This review examines the effects of vaginally applied estrogen on the vaginal epithelium, urethra and endometrium. An accompanying review examines the systemic effects of vaginally applied estrogen.

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“…GSM develops as a direct result of reduced ovarian function and circulating hormone levels [4]. The syndrome is characterised by an involution of the genitourinary mucosa and adjacent vulvo-vaginal tissues and by histologically and clinically apparent changes in type I versus type III collagen ratios and in a reduction in both the quantity of elastic fibres and in vascularisation of the genitourinary tissues [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the CO<sub>2</sub> Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

Pagano¹,

Gieri²,

Nocera³

et al. 2017

JCT

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Objective To evaluate the impact of fractionated CO2 laser therapy on vaginal atrophy and mild/moderate stress urinary incontinence (SUI) symptoms in patients with physiological or surgically-induced menopause. Materials and Methods Post-menopausal patients (n = 33) presenting vaginal atrophy and/or SUI, underwent three vaginal CO2 laser treatment sessions, performed at 1-month intervals. Vaginal symptoms were evaluated using the Vaginal Health Index Score (VHI-S), Visual Analogue Scales (VAS) for dyspareunia and global patient satisfaction. The impact of urinary incontinence on patient quality of life was evaluated using the International Consultation on Incontinence Questionnaire (ICIQ). Symptoms were evaluated before treatment and at every subsequent treatment session, as well as 3 months following the last treatment session. RESULTS The three-session treatment series led to a significant improvement in both subjective symptoms (dryness, burning, dyspareunia) and clinical signs (VHI-S) (P < 0.01). In addition, reductions in the frequency and severity of SUI symptoms (P < 0.01) were noted during the treatment period, and were maintained after for at least 3 months after completion of the treatment course. Improvements in VHI-S were significantly greater in patients with surgically-induced menopause, as compared to those with physiological menopause. The vast majority of patients (90%) were satisfied with the procedure, and reported a significant improvement in quality of life. No adverse events were recorded throughout the study period. Conclusions Fractionated CO2 laser therapy is a safe, effective and easy-to-perform treatment modality for menopause-related vaginal atrophy and SUI.

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Estrogen Receptors in the Human Female Lower Urinary Tract

Cited by 44 publications

References 0 publications

Transobturator Tape Operation Is More Effective in Premenopausal Women than in Postmenopausal Women with Stress Incontinence

Transobturator Tape Operation Is More Effective in Premenopausal Women than in Postmenopausal Women with Stress Incontinence

Local Effects of Vaginally Administered Estrogen Therapy

Evaluation of the CO<sub>2</sub> Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

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Estrogen Receptors in the Human Female Lower Urinary Tract

Cited by 44 publications

References 0 publications

Transobturator Tape Operation Is More Effective in Premenopausal Women than in Postmenopausal Women with Stress Incontinence

Transobturator Tape Operation Is More Effective in Premenopausal Women than in Postmenopausal Women with Stress Incontinence

Local Effects of Vaginally Administered Estrogen Therapy

Evaluation of the CO&lt;sub&gt;2&lt;/sub&gt; Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

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Evaluation of the CO<sub>2</sub> Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results