Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa

Fujinoki, Masakatsu; Takei, Gen L.

doi:10.1262/jrd.2014-116

Cited by 16 publications

(29 citation statements)

References 62 publications

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“…Both the acrosome reaction and the hyperactivation are reported to be necessary for the success of fertilization in vivo and in vitro (Yanagimachi 1994, Quill et al 2003, Ho et al 2009, Alasmari et al 2013. Various factors and events are reported to be associated with the regulation of capacitation (Yanagimachi 1994, Visconti & Kopf 1998, Visconti et al 1998, Fujinoki 2009, Fujinoki et al 2015.…”

Section: Introductionmentioning

confidence: 99%

“…In hamster spermatozoa, hyperactivation is also regulated by various extracellular materials (Fujinoki 2009, Fujinoki et al 2015. Sperm hyperactivation is enhanced by serotonin (Fujinoki 2011), melatonin (Fujinoki 2008), and progesterone (Noguchi et al 2008), whereas enhancement of hyperactivation by progesterone is suppressed by estrogen (Fujinoki 2010) or GABA (Kon et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Sperm hyperactivation is enhanced by serotonin (Fujinoki 2011), melatonin (Fujinoki 2008), and progesterone (Noguchi et al 2008), whereas enhancement of hyperactivation by progesterone is suppressed by estrogen (Fujinoki 2010) or GABA (Kon et al 2014). The enhancement of hyperactivation by melatonin is also suppressed by estrogen (Fujinoki & Takei 2015). These hormones are known to change during female estrous cycle (Louzan et al 1986, Libersky & Boatman 1995, Schillo 2009, and hyperactivation/ capacitation is suggested to be regulated by monitoring the changing environment of the oviduct (Fujinoki 2008, Coy et al 2012.…”

Section: Introductionmentioning

confidence: 99%

“…These hormones are known to change during female estrous cycle (Louzan et al 1986, Libersky & Boatman 1995, Schillo 2009, and hyperactivation/ capacitation is suggested to be regulated by monitoring the changing environment of the oviduct (Fujinoki 2008, Coy et al 2012. In other words, the balance between facilitative factors and suppressive factors regulates the timing of hyperactivation/capacitation to occur precisely at the time when ovum reach to the ampulla after ovulation (Fujinoki 2010, 2014, Kon et al 2014, Fujinoki & Takei 2015. As mentioned above, abundant knowledge about the enhancing or facilitating factors of hyperactivation/ capacitation already exists.…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, spermatozoa of the species that undergo external fertilization, such as teleosts, activate flagellar motility in response to the drastic change of extracellular environment such as osmotic pressure and concentration of the K + (Alavi & Cosson 2006, Takei et al 2012, 2015. The osmolality of the fluids from mammalian male genitalia is generally higher than that of other fluids (Yeung et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of hamster sperm hyperactivation by extracellular Na+

Takei¹,

Fujinoki²

2016

Reproduction

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Mammalian sperm motility has to be hyperactivated to be fertilization-competent. Hyperactivation is regulated by extracellular environment. Osmolality of mammalian semen is higher than that in female reproductive tract; however, the effect of them on hyperactivation has not been investigated. So we investigated the effect of osmotic environment on hyperactivation using hamster spermatozoa at first. Increase in the osmolality of the media (~370 mOsm) by increasing the concentration of NaCl (~150 mmol/L) caused the delay of the expression of hyperactivation. When NaCl concentration varied in the same range (75-150 mmol/L) whereas the osmolality was fixed at 370 mOsm by adding mannitol, the delay of hyperactivation occurred dependent on NaCl concentration. Increase in NaCl concentration also caused suppression of curvilinear velocity, bend angle, and sliding velocity of the flagellum at the onset of incubation, suggesting that NaCl concentration affect both activation and hyperactivation in hamster spermatozoa. Hamster sperm intracellular Ca 2+ concentration decreased as extracellular NaCl concentration increased, whereas membrane potential and intracellular pH were unaffected by extracellular NaCl concentration. SN-6 and SEA0400, inhibitors of Na

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulation of hamster sperm hyperactivation by extracellular Na+

Takei¹,

Fujinoki²

2016

Reproduction

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Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster

Miyashita

Fujinoki

2022

Reprod Medicine & Biology

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Purpose Aging is a major cause of decreased fertility. Using hamster, we examined the effects of aging on testes, epididymides, and sperm. Additionally, we examined whether progesterone (P 4 ), melatonin (Mel) and 5‐hydroxytryptamine (5‐HT) mitigated effects of aging on sperm. Methods Young (10–16 weeks), Adult (5–7 months), Aged (13–15 months), and Old (19–22 months) hamsters were used. Weights of bodies, testes, and epididymides were measured. Testes and epididymides were studied by histological microscopy. Sera were obtained to determine testosterone concentrations. Sperm were analyzed by video‐microscopy. Results By aging, body weights increased but weights of testes and epididymides decreased. Most hamsters were normozoospermia, although several old hamsters were azoospermia. In testes and epididymides, desquamation and structures resembling residual bodies (SRRBs) were observed. Although desquamation was not always related to aging, SRRBs occurred by aging. Testosterone concentrations were not changed in normozoospermic hamsters, but it was significantly reduced in old azoospermic hamster. Aging significantly reduced sperm ability to exhibit hyperactivation. Additionally, aging significantly increased the straight‐line velocity (VSL). P 4 , Mel, and 5‐HT lessened the reduction in sperm hyperactivation and the increasing of VSL. Conclusion Aging reduces qualities of testes, epididymides, and sperm, and P 4 , Mel, and 5‐HT recover reduced quality of sperm.

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Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones

2015

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During capacitation, motility of mammalian spermatozoon is changed from a state of "activation" to "hyperactivation." Recently, it has been suggested that some hormones present in the oviduct are involved in the regulation of this hyperactivation in vitro. Progesterone, melatonin, and serotonin enhance hyperactivation through specific membrane receptors, and 17β-estradiol suppresses this enhancement by progesterone and melatonin via a membrane estrogen receptor. Moreover, γ-aminobutyric acid suppresses progesterone-enhanced hyperactivation through the γ-aminobutyric acid receptor. These hormones dose-dependently affect hyperactivation. Although the complete signaling pathway is not clear, progesterone activates phospholipase C and protein kinases and enhances tyrosine phosphorylation. Moreover, tyrosine phosphorylation is suppressed by 17β-estradiol. This regulation of spermatozoal hyperactivation by steroids is also disrupted by diethylstilbestrol. The in vitro experiments reviewed here suggest that mammalian spermatozoa are able to respond to effects of oviductal hormones. We therefore assume that the enhancement of spermatozoal hyperactivation is also regulated by oviductal hormones in vivo.

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Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa

Cited by 16 publications

References 62 publications

Regulation of hamster sperm hyperactivation by extracellular Na+

Regulation of hamster sperm hyperactivation by extracellular Na+

Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster

Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones

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