Estrogen Treatment Induces Elevated Expression of HMG1 in MCF-7 Cells

Chau, Kai‐Yin; Lam, Hieu; Lee, Kam-Len Daniel

doi:10.1006/excr.1998.4052

Cited by 33 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rationale for the discovery described herein was derived from previous work reporting that the mRNA level of chromosomal architectural protein HMG1 is up-regulated when human MCF-7 breast cancer cells are treated with estrogen (36). We corroborate such overexpression at the protein level.…”

supporting

confidence: 67%

“…For MCF-7 cells, a mammalian breast cancer cell line, a single 10 Ϫ7 M dose of estrogen increases HMG1 mRNA level by 1.5-to 2.5-fold (36). The exact mechanism of this up-regulation is not known, although HMG1 overexpression may be necessary to facilitate transcriptional activation of hormone-responsive genes.…”

Section: Hmg1 Overexpression In Mcf-7 and Evsa-t Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin

Liang²,

Lippard³

2000

Proc. Natl. Acad. Sci. U.S.A.

194

156

View full text Add to dashboard Cite

Cisplatin is an anticancer drug that has enjoyed remarkable success against testicular tumors, but dose limiting side-effects have limited its application against a broader range of cancers. Previous studies have shown that high-mobility group (HMG) domain proteins such as HMG1 sensitize cells to cisplatin by shielding its major DNA adducts from nucleotide excision repair. Estrogen treatment increases HMG1 mRNA levels in breast cancer MCF-7 cells. Herein, we describe that treatment of human cancer cells having steroid hormone receptors with the appropriate hormone, estrogen and͞or progesterone, significantly increases the potency of cisplatin and its analogue carboplatin by causing the overexpression of HMG1. These findings suggest that the proper combination of these drugs, which are already approved by the Food and Drug Administration, could have potential benefit in treating tumors such as ovarian or breast that carry the hormone receptors.

show abstract

supporting

confidence: 67%

Section: Hmg1 Overexpression In Mcf-7 and Evsa-t Cellsmentioning

confidence: 99%

Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin

Liang²,

Lippard³

2000

Proc. Natl. Acad. Sci. U.S.A.

194

156

View full text Add to dashboard Cite

show abstract

“…1). Among these four genes, three have already been reported as estrogen-responsive genes, cathepsin D (28), pS2 (29) and high mobility group 1 protein (30). The remaining gene is identified here as a novel estrogen-responsive gene, WISP-2 (Wnt-1 inducible signaling pathway protein 2).…”

Section: Comparison Of Expression Patterns In E2-untreated and Treatementioning

confidence: 93%

WISP-2 as a Novel Estrogen-Responsive Gene in Human Breast Cancer Cells

Inadera

Hashimoto

Dong

et al. 2000

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

“…Table 1 shows a compilation of the genes that showed consistent estrogendependent regulation across all comparable samples. Several of these genes have been previously reported to be estrogenregulated, including: HMG-1 [15], myc [16], nucleophosmin [17], cathepsin D [18] and TGF␤3 [19]. Recently, ephrin A1 and Id3 were also identified as estrogen-regulated genes using microarrays [20].…”

Section: Microarray Analysis Of Gene Expressionmentioning

confidence: 97%