Estrogenic activity of chlordecone, o,p′-DDT and o,p′-DDE in juvenile rainbow trout: induction of vitellogenesis and interaction with hepatic estrogen binding sites

Donohoe, Regina M.; Curtis, Lawrence R.

doi:10.1016/s0166-445x(96)00799-0

Cited by 162 publications

(109 citation statements)

References 43 publications

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“…Concentrations of individual contaminants and mixtures determined in this study have been shown to have adverse effects in a wide range of animals, including mammals, reptiles, amphibians, and fish (20)(21)(22)(23). Some of the effects described are as follows: alterations of growth and development (24), poor hatching success (22), alterations of the reproductive and nervous system (25,26), learning and behavioral deficits retained throughout life (27,28), abnormalities of the liver and other organ systems (29,30), and endocrine disruption (29,31). Studies have also shown that these contaminants in combination can increase adverse effects by several orders of magnitude (32,33).…”

Section: Discussionmentioning

confidence: 99%

Maternal transfer of xenobiotics and effects on larval striped bass in the San Francisco Estuary

Ostrach

Low-Marchelli

Eder

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Aquatic ecosystems around the world face serious threats from anthropogenic contaminants. Results from 8 years of field and laboratory investigations indicate that sublethal contaminant exposure is occurring in the early life stages of striped bass in the San Francisco Estuary, a population in continual decline since its initial collapse during the 1970s. Biologically significant levels of polychlorinated biphenyls, polybrominated diphenyl ethers, and current-use/legacy pesticides were found in all egg samples from river-collected fish. Developmental changes previously unseen with standard methods were detected with a technique using the principles of unbiased stereology. Abnormal yolk utilization, brain and liver development, and overall growth were observed in larvae from river-collected fish. Histopathological analyses confirmed and identified developmental alterations. Using this methodology enabled us to present a conclusive line of evidence for the maternal transfer of xenobiotics and their adverse effects on larval striped bass in this estuary.Morone saxatilis ͉ contaminants ͉ biomarkers ͉ histopathology ͉ unbiased stereology

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Section: Discussionmentioning

confidence: 99%

Maternal transfer of xenobiotics and effects on larval striped bass in the San Francisco Estuary

Ostrach

Low-Marchelli

Eder

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Although estrogens at this concentration can cause sex reversal (Papoulias et al 1999), the comparatively lower affinity of o,p´-DDE and o,p´-DDT for the ER (Nimrod and Benson 1997) suggests that higher exposures of these compounds are required for sex reversal to occur. Nevertheless, o,p´-DDT and o,p´-DDE at low concentrations may interfere with the binding of natural ligands to a variety of steroid binding moieties (e.g., receptors and binding proteins) (Danzo 1997;Donohoe and Curtis 1996;Gaido et al 1997;Kupfer and Bulger 1976;Lundholm 1998;Mason and Schulte 1980;Nimrod and Benson 1997;Shilling and Williams 2000;Wells and Van Der Kraak 2000), thereby allowing for endocrine-disrupting effects.…”

Section: Discussionmentioning

confidence: 99%

“…However, like o,p´-DDT, o,p´-DDE is believed to work through the ER and to have a similar ER agonist potency (Donohoe and Curtis 1996), and exposure to o,p´-DDE has been associated with decreased fecundity and fertility and increased early oocyte atresia (Hose et al 1989). Recently, Wells and Van Der Kraak (2000) showed that o,p´-DDE and o,p´-DDT will also bind to the androgen receptor in goldfish (Carassius auratus) but not rainbow trout (Oncorhynchus mykiss) testes at approximately half the affinity of p,p´-DDE.…”

mentioning

confidence: 99%

In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

Papoulias

Villalobos

Meadows

et al. 2003

Environ Health Perspect

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Despite being banned in many countries, dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) continue to be found in fish tissues at concentrations of concern. Like o,p -DDT, o,p -DDE is estrogenic and is believed to exert its effects through binding to the estrogen receptor. The limited toxicologic data for o,p -DDE suggest that it decreases fecundity and fertility of fishes. We conducted an egg injection study using the d-rR strain of medaka and environmentally relevant concentrations of o,p -DDE to examine its effects on sexual differentiation and development. The gonads of exposed fish showed no evidence of sex reversal or intersex. However, other gonad abnormalities occurred in exposed individuals. Females exhibited few vitellogenic oocytes and increased atresia. Male testes appeared morphologically normal but were very small. Gonadosomatic index values for both sexes were lower for exposed fish. Our observations of abnormal female and very small male gonads after in ovo o,p -DDE exposure may be indicative of effects on early endocrine processes important for normal ovarian and testicular development.

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“…The 20-HE disruption corroborates the hypothesis that CLD could be endocrine disruptor in invertebrates as already observed in vertebrates. Indeed, several previous studies have demonstrated that CLD could be an endocrine disruptor in vertebrates such as fish (Ankley et al, 1998;Donohoe and Curtis, 1996;Nimrod and Benson, 1997;Sumpter and Jobling, 1995), birds and mammals (Eroschenko, 1981), by having estrogenic properties through interaction with the estrogen-receptor system (Donohoe and Curtis, 1996;Hammond et al, 1979;Rodríguez et al, 2007). In crustaceans, various estrogenic compounds and estrogen receptor agonists (e.g.…”

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 99%

Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii

et al. 2016

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a b s t r a c tChlordecone (CLD) is an organochlorine insecticide abundant in aquatic environment of the French West Indies. However, few studies have investigated its impact on freshwater invertebrates. Whereas CLD is suspected of inducing endocrine disruption, this work aimed to study the effects of environmentally relevant concentrations of CLD on the 20-hydroxyecdysone (20-HE) hormone concentration and on the chitobiase activity, both having key roles in the molting process of crustaceans. In addition, the bioaccumulation of CLD was measured in the muscle tissue of Macrobrachium rosenbergii to underline potential dose-response relationship. The results have shown that CLD was bioaccumulated in exposed organisms according to a trend to a dose-response relationship. Moreover, it was observed that CLD decreased the 20-HE concentration in exposed prawns when compared to control, whatever the duration of exposure, as well as it inhibited the chitobiase activity after 30 days of exposure. The present study indicates that CLD could interfere with molting process of M. rosenbergii by disturbing the 20-HE concentration and the activity of chitobiase, suggesting consequences at the long term on the shrimp development. This study also confirmed that CLD could be an endocrine disruptor in decapod crustaceans, as it was already observed in vertebrates.

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Estrogenic activity of chlordecone, o,p′-DDT and o,p′-DDE in juvenile rainbow trout: induction of vitellogenesis and interaction with hepatic estrogen binding sites

Cited by 162 publications

References 43 publications

Maternal transfer of xenobiotics and effects on larval striped bass in the San Francisco Estuary

Maternal transfer of xenobiotics and effects on larval striped bass in the San Francisco Estuary

In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii

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