Estrogenic compounds determination in water samples by dispersive liquid–liquid microextraction and micellar electrokinetic chromatography coupled to mass spectrometry

D’Orazio, Giovanni; Asensio-Ramos, María; Hernández-Borges, Javier; Fanali, Salvatore; Rodríguez‐Delgado, Miguel Ángel

doi:10.1016/j.chroma.2014.04.005

Cited by 43 publications

(98 citation statements)

References 42 publications

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“…The natural hormones together with their metabolites and conjugates are mainly excreted in the urine of mammals [40]. The proposed SPME-HPLC method and a reported dispersive liquid-liquid microextraction (DLLME) method [29] were applied to determine of the three model steroid estrogens in treated domestic wastewater. Only estrone was found by an SPME method in unspiked water samples but could not be quantified (as shown in Fig.…”

Section: Sample Analysismentioning

confidence: 99%

“…According to the reported optimum conditions in ref. [29], a mixture containing 500 μL of acetonitrile (as dispersion solvent) and 110 μL of chloroform (as extraction solvent) was rapidly introduced into 10 mL of treated domestic wastewater sample (pH 3.0) containing 30 % (w/v) NaCl in a 20 mL screw cap glass tube, followed by 2 min of vortex-shaking. The dispersion was centrifuged at 5000 rpm for 5 min.…”

Section: Real Sample Analysismentioning

confidence: 99%

“…A dispersive liquid-liquid microextraction method [29] was also used to determine the same sample for comparison. According to the reported optimum conditions in ref.…”

Section: Real Sample Analysismentioning

confidence: 99%

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Development of a functionalized polymeric ionic liquid monolith for solid-phase microextraction of polar endocrine disrupting chemicals in aqueous samples coupled to high-performance liquid chromatography

Feng

Sun

et al. 2015

Anal Bioanal Chem

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Ionic liquids (ILs) have been efficiently used as a "designer sorbent" in sample preparation. A novel 1-(3-aminopropyl)-3-(4-vinylbenzyl)imidazolium 4-styrenesulfonate IL monomer was synthesized and copolymerized with 1,6-di(3-vinylimidazolium) hexane bishexafluorophosphate IL as cross-linking agent to prepare a cross-linked polymeric ionic liquids (PILs) monolith. Coupled to high-performance liquid chromatography (HPLC), the PILs monolith was used as a solid-phase microextraction (SPME) sorbent to extract some polar endocrine disrupting chemical (EDCs) such as estrogens, bisphenol A, and phthalate esters in aqueous samples. Preparation and extraction conditions were investigated and optimized to obtain satisfactory extraction efficiency. Limits of detection (LODs) of the proposed method for three steroid estrogens and bisphenol A were 0.25 and 0.2 μg L(-1), respectively, which were lower than or comparable to some other sample preparation methods. Intra- and inter-day repeatability for all the analytes was 2.2-12%. The monolith-to-monolith repeatability was 7.4-15%. The extraction performance of the method for analysis of target estrogens in treated domestic wastewater was investigated and compared with a dispersive liquid-liquid microextraction (DLLME) method. The proposed SPME method provided better sensitivity and higher resistance to matrix interferences.

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Section: Sample Analysismentioning

confidence: 99%

Section: Real Sample Analysismentioning

confidence: 99%

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Development of a functionalized polymeric ionic liquid monolith for solid-phase microextraction of polar endocrine disrupting chemicals in aqueous samples coupled to high-performance liquid chromatography

Feng

Sun

et al. 2015

Anal Bioanal Chem

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“…For examples, liquid-liquid extraction [17,23] SPE [24,25], solid-phase microextraction (SPME) [26,27], stir bar sorptive extraction [28] and cloud-point extraction (CPE) [29] have been reported for estrogens. However, the classical extraction methods, liquidliquid extraction and SPE, require large volumes of organic solvents and long preparation time.…”

Section: Introductionmentioning

confidence: 99%

“…Various analysis techniques have been developed to detect various matrical estrogens, including HPLC [9][10][11], liquid chromatography-mass spectrometry (LC-MS) [12,13], GC [14], CE [15,16], CE coupled to mass spectrometry (CE-MS) [17,18], immunoassay [19] and so on. CE has the advangtages of low solvent consumption, high seperation efficiency, automatic operation and it has been developing quickly [15-18, [20]].…”

Section: Introductionmentioning

confidence: 99%

Dispersive liquid‐liquid microextraction for four phenolic environmental estrogens in water samples followed by determination using capillary electrophoresis

et al. 2016

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Dispersive liquid-liquid microextraction for four phenolic environmental estrogens in water samples followed by determination using capillary electrophoresis Dispersive liquid-liquid microextraction (DLLME) coupled with CE was successfully developed for simultaneous determination of four types of phenolic environmental estrogens (PEEs), namely hexestrol (HS), bisphenol A (BPA), diethylstilbestrol (DES) and dienestrol (DS). Several parameters affecting DLLME and CE conditions were systematically investigated including the type and volume of extraction solvent and dispersive solvent, extraction time, salt, pH value, surfactant, buffer solution and so on. Under the optimal conditions, DLLME-CE exhibited strong enrichment ability, presenting high enrichment factors of 467, 241, 367 and 362 for HS, BPA, DES and DS, respectively, as well as low detection limits of 0.3, 0.6, 0.6 and 0.3 g/L, respectively. Excellent linearity was achieved in the range of 2.0-150 g/L for HS and DS, and 4.0-300 g/L for BPA and DES, with correlation coefficients RϾ0.9983. Recoveries ranging from 70.4 to 108.1% were obtained with tap water, lake water and seawater samples spiked at three concentration levels and the relative standard deviations (RSDs, for n = 5) were 2.1-9.7%. This DLLME-CE method with high selectivity and sensitivity, high stability, simplicity, cost-effectiveness, eco-friendliness was proved potentially applicable for the rapid and simultaneous determination of PEEs in complicated water samples.

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Trends in Multiresidue Analysis

Moreno‐González

Lara

Olmo‐Iruela

et al. 2015

Encyclopedia of Analytical Chemistry

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The global concern about food safety and environment quality has produced the development of a legal framework to control residues of organic compounds (e.g. pesticides and veterinary and human drugs). In this context, the establishment of analytical methods achieving satisfactory performances in terms of sensitivity, selectivity, resolution, identification, sample throughput, and applicability has been mandatory. Multiresidue methods based on chromatographic techniques, mainly gas chromatography (GC) and liquid chromatography (LC), coupled to mass spectrometry (MS), have been applied and sample preparation has evolved through the development of miniaturized and environmentally friendly procedures according to the Green Chemistry. In addition, generic extraction procedures for multiclass analysis have been optimized, increasing sample throughput. Capillary electrophoresis (CE) has emerged as an alternative to LC and GC, owing to the development of on‐line preconcentration strategies for increasing sensitivity. This article aims to show an overview about the current trends in the analysis of pesticide and drugs in food and environmental samples, discussing the relevant advances in sample treatments and the technological evolution of the instrumental techniques. We hope to offer with this article a critical review of the analytical possibilities for routine analysis laboratories.

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Estrogenic compounds determination in water samples by dispersive liquid–liquid microextraction and micellar electrokinetic chromatography coupled to mass spectrometry

Cited by 43 publications

References 42 publications

Development of a functionalized polymeric ionic liquid monolith for solid-phase microextraction of polar endocrine disrupting chemicals in aqueous samples coupled to high-performance liquid chromatography

Development of a functionalized polymeric ionic liquid monolith for solid-phase microextraction of polar endocrine disrupting chemicals in aqueous samples coupled to high-performance liquid chromatography

Dispersive liquid‐liquid microextraction for four phenolic environmental estrogens in water samples followed by determination using capillary electrophoresis

Trends in Multiresidue Analysis

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