Estrogens and Osteoporosis

Lindsay, Robert; Cosman, Felicia

doi:10.1016/b978-012470862-4/50070-2

Osteoporosis 2001

DOI: 10.1016/b978-012470862-4/50070-2

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Estrogens and Osteoporosis

Robert Lindsay

Felicia Cosman

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Cited by 4 publications

(1 citation statement)

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“…In conditions of estrogen deficiency, there is increased production of inflammatory cytokines, as interleukines: IL-1, IL-6, IL-11 and tumour necrosis factors (TNF), these factors stimulate osteoclasts formation. Estrogen has antiresorptive effect as it promotes bone formation by regulating osteoblast proliferation, differentiation and activity and it stimulates the production of antiosteoclastogenic factors including Interleukin-1 receptor antagonist(43). Also Estrogen deficiency increases the stromal production of receptors activator of NFKB ligand (RANKL) and macrophage colony stimulating factor (M-CSF)(44).…”

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confidence: 99%

The potential effect of vitamin D against bone loss and vascular calcification in ovariectomized rats: possible association with serum nitric oxide.

Elwakeel

Shaer

Ghalwash

et al. 2020

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Many epidemiological studies have shown an association between osteoporosis and peripheral vascular disease in postmenopausal women. So the aim of the present study is to investigate the possible effect of vitamin D against postmenopausal bone loss and vascular calcification in adult rats. Methods: 24 female Sprague Dawley rats were divided into 4 groups (N = 6 per group): Group I: control sham-operated rats. Group II: sham operated rats treated with vitamin D. Group III: control ovariectomized (OVX) rats. Group IV: OVX rats treated with vitamin D, rats were injected with 0.04 μg/kg calcitriol active vitamin D intraperitoneally (calcitriol) 3 times a week for 4 weeks.Serum level of estradiol, calcium, phosphorus and osteoblastic markers (alkaline phosphatase and osteocalcin) were measured. Serum levels of lipid profile, parathormone and nitric oxide were also evaluated. The bone and the aortic wall were prepared for histopathological study. In comparisons to the ovariectomized rats, active vitamin D caused significant attenuation of the bone loss, biomechanical fragility and delayed the onset of vascular calcification in the aortic wall. Also it improved the lipid profile, serum nitric oxide levels and suppressed parathyroid hormone level. Conclusion:The administration of vitamin D has a beneficial effect on the bone quality and also a delaying effect on the onset of aortic vascular calcification in ovariectomized rats, with suggestion of possible association with serum nitric oxide. Keywords• vitamin D • Bone loss • Vascular calcification • Nitric oxide Bull. of Egyp. Soc. Physiol. Sci.

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confidence: 99%

The potential effect of vitamin D against bone loss and vascular calcification in ovariectomized rats: possible association with serum nitric oxide.

Elwakeel

Shaer

Ghalwash

et al. 2020

BESPS

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Hormone replacement therapy and risk for foot, distal forearm, proximal humerus, and pelvis fractures

et al. 2003

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This case-control epidemiologic study examines the relationship between hormone replacement therapy (HRT) and risk for fractures of four sites among women 45 years of age and older. From October 1996 to May 2001, incident patients with distal forearm ( n=744), foot ( n=618), proximal humerus ( n=331), and pelvis ( n=109) fractures were recruited from five Kaiser Permanente Medical Centers in northern California. Controls ( n=1617) were selected at random from the same five medical centers over the same time period within strata defined by 5-year age group, gender, and white versus nonwhite or unknown recorded race/ethnicity. Trained interviewers collected information using a standardized questionnaire. Compared with postmenopausal women who never used HRT, postmenopausal women currently using HRT for at least 3 months had a decreased risk of fracture at the distal forearm (adjusted OR=0.55, 95% CI: 0.43, 0.72), proximal humerus (adjusted OR=0.51, 95% CI: 0.36, 0.74), and pelvis (adjusted OR=0.51, 95% CI: 0.27, 0.95), but not the foot (adjusted OR=1.05, 95% CI: 0.81, 1.35). Past use of HRT for more than 7 years also appeared to be associated with a reduced risk of fracture at the distal forearm and proximal humerus. The longer a woman went without HRT after her last menstrual period, the greater her risk of fracture in the distal forearm, proximal humerus, and pelvis. The findings of this study support long-term, current use of HRT for the prevention of osteoporotic fractures, but other risks and benefits also need to be considered.

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Estrogen replacement and cardiovascular disease: Serum lipids and blood pressure effects

Wr¹

1990

Intl J Gynecology & Obste

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Estrogens and Osteoporosis

Cited by 4 publications

References 199 publications

The potential effect of vitamin D against bone loss and vascular calcification in ovariectomized rats: possible association with serum nitric oxide.

The potential effect of vitamin D against bone loss and vascular calcification in ovariectomized rats: possible association with serum nitric oxide.

Hormone replacement therapy and risk for foot, distal forearm, proximal humerus, and pelvis fractures

Estrogen replacement and cardiovascular disease: Serum lipids and blood pressure effects

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