Estrogen replacement and cardiovascular disease: Serum lipids and blood pressure effects

Plasma lipids, lipoproteins and apolipoproteins in hirsute women

“…One of them is the influence on the concentrations of plasma cholesterol fractions, but estrogens also have a direct effect on the vessel wall and rheology. When the estrogen production by the ovarian follicles decreases, the concentrations of plasma cholesterol (CHOL) and low-density lipoprotein cholesterol fraction (LDL) rise (4)(5)(6), and women have a progressive increase in the incidence of cardiovascular disease (7-1 1).…”

A Nurse's Guide to Hormone Replacement Therapy

“…It is thought that norm:il ovarian function provides a protective effect, possihly :iccounting for the increased rates o f cardiovascular disease in women after menopause (Kercsztes bi Dm, 1992;I.oho, 1990). Studies have shown that exogenous estrogen tilay decrease the risk of cardiovascular diseasc hy as niuch as one half (Hazzard, 1989;Henderson, I?iganini-Hill, & Ross, 1991; Nabulsi et a]., 1093; Stai1ipfc.r c't id., 1991 ). One proposed protective mechanism is the fnvocihle iiiipact of circulating estrogen on serum lipid lcvels , 1991).…”